Computing Network of Diseases and Pharmacological Entities through the Integration of Distributed Literature Mining and Ontology Mapping

The proliferation of -omics (such as, Genomics, Proteomics) and -ology (such as, System Biology, Cell Biology, Pharmacology) have spawned new frontiers of research in drug discovery and personalized medicine. A vast amount (21 million) of published research results are archived in the PubMed and are continually growing in size. To improve the accessibility and utility of such a large number of literatures, it is critical to develop a suit of semantic sensitive technology that is capable of discovering knowledge and can also infer possible new relationships based on statistical co-occurrences of meaningful terms or concepts. In this context, this thesis presents a unified framework to mine a large number of literatures through the integration of latent semantic analysis (LSA) and ontology mapping. In particular, a parameter optimized, robust, scalable, and distributed LSA (DiLSA) technique was designed and implemented on a carefully selected 7.4 million PubMed records related to pharmacology. The DiLSA model was integrated with MeSH to make the model effective and efficient for a specific domain. An optimized multi-gram dictionary was customized by mapping the MeSH to build the DiLSA model. A fully integrated web-based application, called PharmNet, was developed to bridge the gap between biological knowledge and clinical practices. Preliminary analysis using the PharmNet shows an improved performance over global LSA model. A limited expert evaluation was performed to validate the retrieved results and network with biological literatures. A thorough performance evaluation and validation of results is in progress

Factors shaping the evolution of electronic documentation systems

The main goal is to prepare the space station technical and managerial structure for likely changes in the creation, capture, transfer, and utilization of knowledge. By anticipating advances, the design of Space Station Project (SSP) information systems can be tailored to facilitate a progression of increasingly sophisticated strategies as the space station evolves. Future generations of advanced information systems will use increases in power to deliver environmentally meaningful, contextually targeted, interconnected data (knowledge). The concept of a Knowledge Base Management System is emerging when the problem is focused on how information systems can perform such a conversion of raw data. Such a system would include traditional management functions for large space databases. Added artificial intelligence features might encompass co-existing knowledge representation schemes; effective control structures for deductive, plausible, and inductive reasoning; means for knowledge acquisition, refinement, and validation; explanation facilities; and dynamic human intervention. The major areas covered include: alternative knowledge representation approaches; advanced user interface capabilities; computer-supported cooperative work; the evolution of information system hardware; standardization, compatibility, and connectivity; and organizational impacts of information intensive environments

Control and Analysis for Sequential Information based on Machine Learning

Sequential information is crucial for real-world applications that are related to time, which is same with time-series being described by sequence data followed by temporal order and regular intervals. In this thesis, we consider four major tasks of sequential information that include sequential trend prediction, control strategy optimisation, visual-temporal interpolation and visual-semantic sequential alignment. We develop machine learning theories and provide state-of-the-art models for various real-world applications that involve sequential processes, including the industrial batch process, sequential video inpainting, and sequential visual-semantic image captioning. The ultimate goal is about designing a hybrid framework that can unify diverse sequential information analysis and control systems For industrial process, control algorithms rely on simulations to find the optimal control strategy. However, few machine learning techniques can control the process using raw data, although some works use ML to predict trends. Most control methods rely on amounts of previous experiences, and cannot execute future information to optimize the control strategy. To improve the effectiveness of the industrial process, we propose improved reinforcement learning approaches that can modify the control strategy. We also propose a hybrid reinforcement virtual learning approach to optimise the long-term control strategy. This approach creates a virtual space that interacts with reinforcement learning to predict a virtual strategy without conducting any real experiments, thereby improving and optimising control efficiency. For sequential visual information analysis, we propose a dual-fusion transformer model to tackle the sequential visual-temporal encoding in video inpainting tasks. Our framework includes a flow-guided transformer with dual attention fusion, and we observe that the sequential information is effectively processed, resulting in promising inpainting videos. Finally, we propose a cycle-based captioning model for the analysis of sequential visual-semantic information. This model augments data from two views to optimise caption generation from an image, overcoming new few-shot and zero-shot settings. The proposed model can generate more accurate and informative captions by leveraging sequential visual-semantic information. Overall, the thesis contributes to analysing and manipulating sequential information in multi-modal real-world applications. Our flexible framework design provides a unified theoretical foundation to deploy sequential information systems in distinctive application domains. Considering the diversity of challenges addressed in this thesis, we believe our technique paves the pathway towards versatile AI in the new era

Products and Services

Today’s global economy offers more opportunities, but is also more complex and competitive than ever before. This fact leads to a wide range of research activity in different fields of interest, especially in the so-called high-tech sectors. This book is a result of widespread research and development activity from many researchers worldwide, covering the aspects of development activities in general, as well as various aspects of the practical application of knowledge

A study of word association aids in information retrieval

Issued as Final project reports [nos. 1-2], Project no. G-36-65

Procedurally Rhetorical Verb-Centric Frame Semantics as a Knowledge Representation for Argumentation Analysis of Biochemistry Articles

The central focus of this thesis is rhetorical moves in biochemistry articles. Kanoksilapatham has provided a descriptive theory of rhetorical moves that extends Swales' CARS model to the complete biochemistry article. The thesis begins the construction of a computational model of this descriptive theory. Attention is placed on the Methods section of the articles. We hypothesize that because authors' argumentation closely follows their experimental procedure, procedural verbs may be the guide to understanding the rhetorical moves. Our work proposes an extension to the normal (i.e., VerbNet) semantic roles especially tuned to this domain. A major contribution is a corpus of Method sections that have been marked up for rhetorical moves and semantic roles. The writing style of this genre tends to occasionally omit semantic roles, so another important contribution is a prototype ontology that provides experimental procedure knowledge for the biochemistry domain. Our computational model employs machine learning to build its models for the semantic roles and rhetorical moves, validated against a gold standard reflecting the annotation of these texts by human experts. We provide significant insights into how to derive these annotations, and as such have contributions as well to the general challenge of producing markups in the domain of biomedical science documents, where specialized knowledge is required