575 research outputs found

    RDFScape: Semantic Web meets Systems Biology

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    <p>Abstract</p> <p>Background</p> <p>The recent availability of high-throughput data in molecular biology has increased the need for a formal representation of this knowledge domain. New ontologies are being developed to formalize knowledge, e.g. about the functions of proteins. As the Semantic Web is being introduced into the Life Sciences, the basis for a distributed knowledge-base that can foster biological data analysis is laid. However, there still is a dichotomy, in tools and methodologies, between the use of ontologies in biological investigation, that is, in relation to experimental observations, and their use as a knowledge-base.</p> <p>Results</p> <p>RDFScape is a plugin that has been developed to extend a software oriented to biological analysis with support for reasoning on ontologies in the semantic web framework. We show with this plugin how the use of ontological knowledge in biological analysis can be extended through the use of inference. In particular, we present two examples relative to ontologies representing biological pathways: we demonstrate how these can be abstracted and visualized as interaction networks, and how reasoning on causal dependencies within elements of pathways can be implemented.</p> <p>Conclusions</p> <p>The use of ontologies for the interpretation of high-throughput biological data can be improved through the use of inference. This allows the use of ontologies not only as annotations, but as a knowledge-base from which new information relevant for specific analysis can be derived.</p

    Ontological interpretation of network monitoring data

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    Interpreting measurement and monitoring data from networks in general and the Internet in particular is a challenge. The motivation for this work has been to in- vestigate new ways to bridge the gap between the kind of data which are available and the more developed information which is needed by network stakeholders to support decision making and network management. Specific problems of syntax, semantics, conflicting data and modeling domain-specific knowledge have been identified. The methods developed and tested have used the Resource Descrip- tion Framework (rdf) and the ontology languages of the Semantic Web to bring together data from disparate sources into unified knowledgebases in two discrete case studies, both using real network data. Those knowledgebases have then been demonstrated to be usable and valuable sources of information about the networks concerned. Some success has been achieved in overcoming each of the identified problems using these techniques, proving the thesis that taking an ontological ap- proach to the processing of network monitoring data can be a very useful technique for overcoming problems of interpretation and for making information available to those who need it

    Datalog± Ontology Consolidation

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    Knowledge bases in the form of ontologies are receiving increasing attention as they allow to clearly represent both the available knowledge, which includes the knowledge in itself and the constraints imposed to it by the domain or the users. In particular, Datalog ± ontologies are attractive because of their property of decidability and the possibility of dealing with the massive amounts of data in real world environments; however, as it is the case with many other ontological languages, their application in collaborative environments often lead to inconsistency related issues. In this paper we introduce the notion of incoherence regarding Datalog± ontologies, in terms of satisfiability of sets of constraints, and show how under specific conditions incoherence leads to inconsistent Datalog ± ontologies. The main contribution of this work is a novel approach to restore both consistency and coherence in Datalog± ontologies. The proposed approach is based on kernel contraction and restoration is performed by the application of incision functions that select formulas to delete. Nevertheless, instead of working over minimal incoherent/inconsistent sets encountered in the ontologies, our operators produce incisions over non-minimal structures called clusters. We present a construction for consolidation operators, along with the properties expected to be satisfied by them. Finally, we establish the relation between the construction and the properties by means of a representation theorem. Although this proposal is presented for Datalog± ontologies consolidation, these operators can be applied to other types of ontological languages, such as Description Logics, making them apt to be used in collaborative environments like the Semantic Web.Fil: Deagustini, Cristhian Ariel David. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias e Ingeniería de la Computación. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación. Instituto de Ciencias e Ingeniería de la Computación; ArgentinaFil: Martinez, Maria Vanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias e Ingeniería de la Computación. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación. Instituto de Ciencias e Ingeniería de la Computación; ArgentinaFil: Falappa, Marcelo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias e Ingeniería de la Computación. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación. Instituto de Ciencias e Ingeniería de la Computación; ArgentinaFil: Simari, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias e Ingeniería de la Computación. Universidad Nacional del Sur. Departamento de Ciencias e Ingeniería de la Computación. Instituto de Ciencias e Ingeniería de la Computación; Argentin

    Rule-Based Intelligence on the Semantic Web: Implications for Military Capabilities

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    Rules are a key element of the Semantic Web vision, promising to provide a foundation for reasoning capabilities that underpin the intelligent manipulation and exploitation of information content. Although ontologies provide the basis for some forms of reasoning, it is unlikely that ontologies, by themselves, will support the range of knowledge-based services that are likely to be required on the Semantic Web. As such, it is important to consider the contribution that rule-based systems can make to the realization of advanced machine intelligence on the Semantic Web. This report aims to review the current state-of-the-art with respect to semantic rule-based technologies. It provides an overview of the rules, rule languages and rule engines that are currently available to support ontology-based reasoning, and it discusses some of the limitations of these technologies in terms of their inability to cope with uncertain or imprecise data and their poor performance in some reasoning contexts. This report also describes the contribution of reasoning systems to military capabilities, and suggests that current technological shortcomings pose a significant barrier to the widespread adoption of reasoning systems within the defence community. Some solutions to these shortcomings are presented and a timescale for technology adoption within the military domain is proposed. It is suggested that application areas such as semantic integration, semantic interoperability, data fusion and situation awareness provide the best opportunities for technology adoption within the 2015 timeframe. Other capabilities, such as decision support and the emulation of human-style reasoning capabilities are seen to depend on the resolution of significant challenges that may hinder attempts at technology adoption and exploitation within the 2020 timeframe
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