Hybrid Intelligent System for Diagnosing Breast Pre-Cancerous and Cancerous Conditions Based on Image Analysis

Modern diagnostic technologies are automated microscopy systems (AMSs). In this research study, the authors analyzed the modern AMS methods and algorithms. Criteria-based comparative analysis of AMS has been made, and their advantages and disadvantages have been identified at the three main levels of image processing. This allowed determining the main direction of such systems development, that is, designing the hybrid intelligent AMS. The work of an expert physician implies visual image interpretation, selection of qualitative features of micro-objects, the formation of diagnostic rules based on expert knowledge, and making diagnoses. Knowledge introduction model contains a productive model, in which knowledge is presented in the form of rules expressed in productive pseudo code if-then. Logic inference machine is a module designed to logically derive the facts and rules from the base according to the laws of formal logic. A set of modern methods and algorithms for low-, mid-, and high-level image processing have been used in the AMS structure

Histopathological image analysis : a review

Over the past decade, dramatic increases in computational power and improvement in image analysis algorithms have allowed the development of powerful computer-assisted analytical approaches to radiological data. With the recent advent of whole slide digital scanners, tissue histopathology slides can now be digitized and stored in digital image form. Consequently, digitized tissue histopathology has now become amenable to the application of computerized image analysis and machine learning techniques. Analogous to the role of computer-assisted diagnosis (CAD) algorithms in medical imaging to complement the opinion of a radiologist, CAD algorithms have begun to be developed for disease detection, diagnosis, and prognosis prediction to complement the opinion of the pathologist. In this paper, we review the recent state of the art CAD technology for digitized histopathology. This paper also briefly describes the development and application of novel image analysis technology for a few specific histopathology related problems being pursued in the United States and Europe

Added benefits of computer-assisted analysis of Hematoxylin-Eosin stained breast histopathological digital slides

This thesis aims at determining if computer-assisted analysis can be used to better understand pathologists’ perception of mitotic figures on Hematoxylin-Eosin (HE) stained breast histopathological digital slides. It also explores the feasibility of reproducible histologic nuclear atypia scoring by incorporating computer-assisted analysis to cytological scores given by a pathologist. In addition, this thesis investigates the possibility of computer-assisted diagnosis for categorizing HE breast images into different subtypes of cancer or benign masses. In the first study, a data set of 453 mitoses and 265 miscounted non-mitoses within breast cancer digital slides were considered. Different features were extracted from the objects in different channels of eight colour spaces. The findings from the first research study suggested that computer-aided image analysis can provide a better understanding of image-related features related to discrepancies among pathologists in recognition of mitoses. Two tasks done routinely by the pathologists are making diagnosis and grading the breast cancer. In the second study, a new tool for reproducible nuclear atypia scoring in breast cancer histological images was proposed. The third study proposed and tested MuDeRN (MUlti-category classification of breast histopathological image using DEep Residual Networks), which is a framework for classifying hematoxylin-eosin stained breast digital slides either as benign or cancer, and then categorizing cancer and benign cases into four different subtypes each. The studies indicated that computer-assisted analysis can aid in both nuclear grading (COMPASS) and breast cancer diagnosis (MuDeRN). The results could be used to improve current status of breast cancer prognosis estimation through reducing the inter-pathologist disagreement in counting mitotic figures and reproducible nuclear grading. It can also improve providing a second opinion to the pathologist for making a diagnosis

Segmentation algorithms of biomedical images: development and quantitative evaluation

The article presents the comparative analysis of the biomedical image segmentation methods. The work discusses segmentation methods on the basis of previous labeling and spatial moments. The experimental results show that the developed methods have higher accuracy by signal-noise ratio compared to the nowadays known. Moreover the authors have developed the quantitative evaluation of the segmentation algorithms based on the metrical approach.У статті представлений порівняльний аналіз методів сегментації біомедичних зображень. У роботі досліджуються методи сегментації на основі попередньої розмітки та просторових моментів. Експериментальні результати показують, що розроблені методи мають більш високу точність за співвідношенням сигнал-шум у порівнянні з відомими. Крім того, автори розробили алгоритм кількісної оцінки алгоритмів сегментації на основі метричного підходу.The proposed research has been developed within the state budget project "Hybrid Intelligent Information Technology Diagnosing of Precancerous Breast Cancer Based on Image Analysis" (state registration number 1016U002500)

Radial Basis Function Artificial Neural Network for the Investigation of Thyroid Cytological Lesions

Objective. This study investigates the potential of an artificial intelligence (AI) methodology, the radial basis function (RBF) artificial neural network (ANN), in the evaluation of thyroid lesions. Study Design. The study was performed on 447 patients who had both cytological and histological evaluation in agreement. Cytological specimens were prepared using liquid-based cytology, and the histological result was based on subsequent surgical samples. Each specimen was digitized; on these images, nuclear morphology features were measured by the use of an image analysis system. The extracted measurements (41,324 nuclei) were separated into two sets: the training set that was used to create the RBF ANN and the test set that was used to evaluate the RBF performance. The system aimed to predict the histological status as benign or malignant. Results. The RBF ANN obtained in the training set has sensitivity 82.5%, specificity 94.6%, and overall accuracy 90.3%, while in the test set, these indices were 81.4%, 90.0%, and 86.9%, respectively. Algorithm was used to classify patients on the basis of the RBF ANN, the overall sensitivity was 95.0%, the specificity was 95.5%, and no statistically significant difference was observed. Conclusion. AI techniques and especially ANNs, only in the recent years, have been studied extensively. The proposed approach is promising to avoid misdiagnoses and assists the everyday practice of the cytopathology. The major drawback in this approach is the automation of a procedure to accurately detect and measure cell nuclei from the digitized images