A Network-based Asynchronous Architecture for Cryptographic Devices

Institute for Computing Systems ArchitectureThe traditional model of cryptography examines the security of the cipher as a mathematical function. However, ciphers that are secure when specified as mathematical functions are not necessarily secure in real-world implementations. The physical implementations of ciphers can be extremely difficult to control and often leak socalled side-channel information. Side-channel cryptanalysis attacks have shown to be especially effective as a practical means for attacking implementations of cryptographic algorithms on simple hardware platforms, such as smart-cards. Adversaries can obtain sensitive information from side-channels, such as the timing of operations, power consumption and electromagnetic emissions. Some of the attack techniques require surprisingly little side-channel information to break some of the best known ciphers. In constrained devices, such as smart-cards, straightforward implementations of cryptographic algorithms can be broken with minimal work. Preventing these attacks has become an active and a challenging area of research. Power analysis is a successful cryptanalytic technique that extracts secret information from cryptographic devices by analysing the power consumed during their operation. A particularly dangerous class of power analysis, differential power analysis (DPA), relies on the correlation of power consumption measurements. It has been proposed that adding non-determinism to the execution of the cryptographic device would reduce the danger of these attacks. It has also been demonstrated that asynchronous logic has advantages for security-sensitive applications. This thesis investigates the security and performance advantages of using a network-based asynchronous architecture, in which the functional units of the datapath form a network. Non-deterministic execution is achieved by exploiting concurrent execution of instructions both with and without data-dependencies; and by forwarding register values between instructions with data-dependencies using randomised routing over the network. The executions of cryptographic algorithms on different architectural configurations are simulated, and the obtained power traces are subjected to DPA attacks. The results show that the proposed architecture introduces a level of non-determinism in the execution that significantly raises the threshold for DPA attacks to succeed. In addition, the performance analysis shows that the improved security does not degrade performance

An Algorithmic Theory of the Policy Process

With a few exceptions, current theories of the policy process do not model or measure the policy process using the graphical process notations that are common within information science, business administration and many natural sciences. The reason is that in the post-war period the needs of business process analysis came to dominate social science applications of process science whilst the needs of public policy process analysis remained largely unaddressed. As a result, modern graphical process notations can encode and quantify the instrumental properties of cost and efficiency of a business process, but not the normative properties of transparency, accountability or legitimacy of the much more complex policy making process. There have been many other unfortunate consequences. Business process modelling evolved into business process reengineering and became a critical enabler of a period of unprecedented hyper-globalization commencing in the 1990’s. However, it did so by encoding and quantifying the instrumental dimensions of cost and efficiency of globalized production processes and not their normative dimensions of domestic employment and social welfare transfers. We live with the consequences to this day of the emergence of destabilizing populist national movements and rising security and defense tensions between former trading partners. However, in recent years, there have been several important new developments. Firstly, a new class of process modelling tools has emerged at the juncture of the disciplines of information science and business administration that can model much more complex governance and policy-making processes as rules based declarative process graphs instead of sequence based imperative process graphs. Secondly, information science is now introducing a capacity for normative reasoning and moral dilemma resolution into a range of technologies from multi-agent systems and artificial societies to self-driving vehicles and autonomous battle drones. This creates new opportunities for a collaboration between policy process analysis and information science to reengineer legacy policy making processes and organizations in terms of normatively driven declarative processes. Not only must these reengineered policy making processes score better against instrumental criteria of cost and efficiency but also against the normative criteria of transparency, accountability, and legitimacy. Consequently, the metrics presented in this dissertation re-connect public policy process analysis with the tools and results of decades of process research in the fields of information science, business administration and many natural sciences, and supports a new theory of the public policy process as an algorithm whose purpose is the generation of solutions to public goods allocation problems. To illustrate the principles of the techniques involved and the utility of the approach, a case study analysis and prediction of Chinese public health policy response to the COVID-19 pandemic of 2020/21 is presented

Emerging model spedies driven by transciptomics

This work is focused on 'emerging model species', i.e. question-driven model species which have sufficient molecular resources to investigate a specific phenomenon in molecular biology, developmental biology, molecular ecology and evolution or related molecular fields. This thesis shows how transcriptomic data can be generated, analyzed, and used to investigate such phenomena of interest even in species lacking a reference genome. The initial ButterflyBase resource has proven to be useful to researchers of species without a reference genome but is limited to the Lepidoptera and supports only the older Sanger sequencing technologies. Thanks to Next Generation Sequencing, transcriptome sequencing is more cost effective but the bottleneck of transcriptomic projects is now the bioinformatic analysis and data mining/dissemination. Therefore, this work continues with presenting novel and innovative approaches which effectively overcome this bottleneck. The est2assembly software produces deeply annotated reference transcriptomes stored in the Chado database. The Drupal Bioinformatic Server Framework and genes4all provide species-neutral and an innovative approach in building standardized online databases and associated web services. All public insect mRNA data were analyzed with est2assembly and genes4all to produce the InsectaCentral. With InsectaCentral, a powerful resource is now available to assist molecular biology in any question-driven model insect species. The software presented here was developed according to specifications of the General Model Organism Database (GMOD) community. All software specifications are species-neutral and can be seamlessly deployed to assist any research community. Further through a case studies chapter, it becomes apparent that the transcriptomic approach is more cost-effective than a genomic approach and therefore sequence-driven evolutionary biology will benefit faster with this field

Polysaccharide utilization loci and associated genes in marine Bacteroidetes - compositional diversity and ecological relevance

The synthesis of marine organic carbon compounds by photosynthetic macroalgae, microalgae (phytoplankton) and bacteria provide a basis for life in the ocean. In marine surface waters this primary production is largely dominated by microalgae and is especially pronounced during spring phytoplankton blooms. During and after these often diatom-dominated blooms, increased amounts of organic matter are released into the surrounding waters. Here, the organic matter, rich in polysaccharides, can trigger blooms of heterotrophic bacteria. Marine members of the Bacteroidetes are consistently found related to such bloom events. These bacteria are regularly detected as the first responders to thrive after phytoplankton spring blooms in temperate coastal regions and are often equipped with a variety of polysaccharide utilization gene clusters. These gene clusters, termed polysaccharide utilization loci (PULs), encode enzymes for the extracellular hydrolysis of polysaccharides and the subsequent uptake of oligosaccharides into the periplasm, where they are shielded from competing bacteria. This mechanism allows for rapid uptake and substrate hoarding, and thus could be one reason why Bacteroidetes are often seen as the first responders of the bacterioplankton community. The investigation of the so far largely unknown diversity and the ecological relevance of PULs in marine Bacteroidetes was the major goal of the work presented here. We could show that genomes of Bacteroidetes isolates from the North Sea, with free-living to micro- and macro-algae associated lifestyles, harboured a variety of these loci predicted to target in total 18 different substrate classes. Overall PUL repertoires of these isolates showed considerable intra-genus and inter-genus, variations suggesting that Bacteroidetes species harbour distinct glycan niches, independent of their phylogenetic relationships. By investigating the PUL repertoires of uncultured free-living Bacteroidetes during three consecutive years of spring phytoplankton blooms at the North Sea island of Helgoland, I could further reveal that the set of targeted substrates during these bloom events was dominated by only five of the substrate classes targeted by the isolates. These were the diatom storage polysaccharide laminarin, alpha-glucans, alginates, as well as substrates rich in alpha-mannans and sulfated xylans. In addition to this constrained set of substrate classes targeted by the free-living Bacteroidetes community, I could show that the species diversity during these blooms was limited and dominated by only 27 abundant and recurrent species that carried a limited number of abundant PULs. The majority of these PULs were targeting laminarin and alpha-glucan substrates, which were likely targeted during the entire time of the blooms. The less frequent PULs, targeting alpha-mannans and sulfated xylans, were predominantly detected during mid- and late- bloom phases, suggesting a relevance of these two substrate classes in the later phases of phytoplankton blooms. Overall these findings highlight the recurrence of a few specialized Bacteroidetes species and the environmental relevance of specific polysaccharide substrate classes during spring phytoplankton blooms. However, for some of these substrate classes the origin, structural details and their abundance during blooms are as yet largely unknown. To further shed light on the polysaccharide niches of abundant key-players, these findings can serve as a guide for future laboratory studies

LIPIcs, Volume 248, ISAAC 2022, Complete Volume

LIPIcs, Volume 248, ISAAC 2022, Complete Volum

Biomedical Engineering

Biomedical engineering is currently relatively wide scientific area which has been constantly bringing innovations with an objective to support and improve all areas of medicine such as therapy, diagnostics and rehabilitation. It holds a strong position also in natural and biological sciences. In the terms of application, biomedical engineering is present at almost all technical universities where some of them are targeted for the research and development in this area. The presented book brings chosen outputs and results of research and development tasks, often supported by important world or European framework programs or grant agencies. The knowledge and findings from the area of biomaterials, bioelectronics, bioinformatics, biomedical devices and tools or computer support in the processes of diagnostics and therapy are defined in a way that they bring both basic information to a reader and also specific outputs with a possible further use in research and development