146,451 research outputs found
Robust Control Structure Selection
Screening tools for control structure selection in the presence of model/plant mismatch are developed in the context of the Structured Singular Value (Ό) theory. The developed screening tools are designed to aid engineers in the elimination of undesirable control structure candidates for which a robustly performing controller does not exist. Through application on a multicomponent distillation column, it is demonstrated that the developed screening tools can be effective in choosing an appropriate control structure while previously existing methods such as the Condition Number Criterion can lead to erroneous results
Improved branch and bound method for control structure screening
The main aim of this paper is to present an improved algorithm of âBranch and
Boundâ method for control structure screening. The new algorithm uses a best-
first search approach, which is more efficient than other algorithms based on
depth-first search approaches. Detailed explanation of the algorithms is
provided in this paper along with a case study on TennesseeâEastman process to
justify the theory of branch and bound method. The case study uses the Hankel
singular value to screen control structure for stabilization. The branch and
bound method provides a global ranking to all possible input and output
combinations. Based on this ranking an efficient control structure with least
complexity for stabilizing control is detected which leads to a decentralized
proportional cont
Simulation in manufacturing and business: A review
Copyright @ 2009 Elsevier B.V.This paper reports the results of a review of simulation applications published within peer-reviewed literature between 1997 and 2006 to provide an up-to-date picture of the role of simulation techniques within manufacturing and business. The review is characterised by three factors: wide coverage, broad scope of the simulation techniques, and a focus on real-world applications. A structured methodology was followed to narrow down the search from around 20,000 papers to 281. Results include interesting trends and patterns. For instance, although discrete event simulation is the most popular technique, it has lower stakeholder engagement than other techniques, such as system dynamics or gaming. This is highly correlated with modelling lead time and purpose. Considering application areas, modelling is mostly used in scheduling. Finally, this review shows an increasing interest in hybrid modelling as an approach to cope with complex enterprise-wide systems
Designing algorithms to aid discovery by chemical robots
Recently, automated robotic systems have become very efficient, thanks to improved coupling between sensor systems and algorithms, of which the latter have been gaining significance thanks to the increase in computing power over the past few decades. However, intelligent automated chemistry platforms for discovery orientated tasks need to be able to cope with the unknown, which is a profoundly hard problem. In this Outlook, we describe how recent advances in the design and application of algorithms, coupled with the increased amount of chemical data available, and automation and control systems may allow more productive chemical research and the development of chemical robots able to target discovery. This is shown through examples of workflow and data processing with automation and control, and through the use of both well-used and cutting-edge algorithms illustrated using recent studies in chemistry. Finally, several algorithms are presented in relation to chemical robots and chemical intelligence for knowledge discovery
HealthCare Partners: Building on a Foundation of Global Risk Management to Achieve Accountable Care
Describes the progress of a medical group and independent practice association in forming an accountable care organization by working with insurers as part of the Brookings-Dartmouth ACO Pilot Program. Lists lessons learned and elements of success
Synthetic biology and microdevices : a powerful combination
Recent developments demonstrate that the combination of microbiology with micro-and nanoelectronics is a successful approach to develop new miniaturized sensing devices and other technologies. In the last decade, there has been a shift from the optimization of the abiotic components, for example, the chip, to the improvement of the processing capabilities of cells through genetic engineering. The synthetic biology approach will not only give rise to systems with new functionalities, but will also improve the robustness and speed of their response towards applied signals. To this end, the development of new genetic circuits has to be guided by computational design methods that enable to tune and optimize the circuit response. As the successful design of genetic circuits is highly dependent on the quality and reliability of its composing elements, intense characterization of standard biological parts will be crucial for an efficient rational design process in the development of new genetic circuits. Microengineered devices can thereby offer a new analytical approach for the study of complex biological parts and systems. By summarizing the recent techniques in creating new synthetic circuits and in integrating biology with microdevices, this review aims at emphasizing the power of combining synthetic biology with microfluidics and microelectronics
Sparse Proteomics Analysis - A compressed sensing-based approach for feature selection and classification of high-dimensional proteomics mass spectrometry data
Background: High-throughput proteomics techniques, such as mass spectrometry
(MS)-based approaches, produce very high-dimensional data-sets. In a clinical
setting one is often interested in how mass spectra differ between patients of
different classes, for example spectra from healthy patients vs. spectra from
patients having a particular disease. Machine learning algorithms are needed to
(a) identify these discriminating features and (b) classify unknown spectra
based on this feature set. Since the acquired data is usually noisy, the
algorithms should be robust against noise and outliers, while the identified
feature set should be as small as possible.
Results: We present a new algorithm, Sparse Proteomics Analysis (SPA), based
on the theory of compressed sensing that allows us to identify a minimal
discriminating set of features from mass spectrometry data-sets. We show (1)
how our method performs on artificial and real-world data-sets, (2) that its
performance is competitive with standard (and widely used) algorithms for
analyzing proteomics data, and (3) that it is robust against random and
systematic noise. We further demonstrate the applicability of our algorithm to
two previously published clinical data-sets
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