14,626 research outputs found
Masking Strategies for Image Manifolds
We consider the problem of selecting an optimal mask for an image manifold,
i.e., choosing a subset of the pixels of the image that preserves the
manifold's geometric structure present in the original data. Such masking
implements a form of compressive sensing through emerging imaging sensor
platforms for which the power expense grows with the number of pixels acquired.
Our goal is for the manifold learned from masked images to resemble its full
image counterpart as closely as possible. More precisely, we show that one can
indeed accurately learn an image manifold without having to consider a large
majority of the image pixels. In doing so, we consider two masking methods that
preserve the local and global geometric structure of the manifold,
respectively. In each case, the process of finding the optimal masking pattern
can be cast as a binary integer program, which is computationally expensive but
can be approximated by a fast greedy algorithm. Numerical experiments show that
the relevant manifold structure is preserved through the data-dependent masking
process, even for modest mask sizes
Machine Learning and Integrative Analysis of Biomedical Big Data.
Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues
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