200 research outputs found
Computational techniques to interpret the neural code underlying complex cognitive processes
Advances in large-scale neural recording technology have significantly improved the
capacity to further elucidate the neural code underlying complex cognitive processes.
This thesis aimed to investigate two research questions in rodent models. First, what
is the role of the hippocampus in memory and specifically what is the underlying
neural code that contributes to spatial memory and navigational decision-making.
Second, how is social cognition represented in the medial prefrontal cortex at the
level of individual neurons. To start, the thesis begins by investigating memory and
social cognition in the context of healthy and diseased states that use non-invasive
methods (i.e. fMRI and animal behavioural studies). The main body of the thesis
then shifts to developing our fundamental understanding of the neural mechanisms
underpinning these cognitive processes by applying computational techniques to ana lyse stable large-scale neural recordings. To achieve this, tailored calcium imaging
and behaviour preprocessing computational pipelines were developed and optimised
for use in social interaction and spatial navigation experimental analysis. In parallel,
a review was conducted on methods for multivariate/neural population analysis. A
comparison of multiple neural manifold learning (NML) algorithms identified that non linear algorithms such as UMAP are more adaptable across datasets of varying noise
and behavioural complexity. Furthermore, the review visualises how NML can be
applied to disease states in the brain and introduces the secondary analyses that
can be used to enhance or characterise a neural manifold. Lastly, the preprocessing
and analytical pipelines were combined to investigate the neural mechanisms in volved in social cognition and spatial memory. The social cognition study explored
how neural firing in the medial Prefrontal cortex changed as a function of the social
dominance paradigm, the "Tube Test". The univariate analysis identified an ensemble
of behavioural-tuned neurons that fire preferentially during specific behaviours such
as "pushing" or "retreating" for the animal’s own behaviour and/or the competitor’s
behaviour. Furthermore, in dominant animals, the neural population exhibited greater
average firing than that of subordinate animals. Next, to investigate spatial memory,
a spatial recency task was used, where rats learnt to navigate towards one of three
reward locations and then recall the rewarded location of the session. During the
task, over 1000 neurons were recorded from the hippocampal CA1 region for five rats
over multiple sessions. Multivariate analysis revealed that the sequence of neurons encoding an animal’s spatial position leading up to a rewarded location was also active
in the decision period before the animal navigates to the rewarded location. The result
posits that prospective replay of neural sequences in the hippocampal CA1 region
could provide a mechanism by which decision-making is supported
Peering into the Dark: Investigating dark matter and neutrinos with cosmology and astrophysics
The LCDM model of modern cosmology provides a highly accurate description of our universe.
However, it relies on two mysterious components, dark matter and dark energy. The cold dark matter
paradigm does not provide a satisfying description of its particle nature, nor any link to the Standard
Model of particle physics.
I investigate the consequences for cosmological structure formation in models with a coupling
between dark matter and Standard Model neutrinos, as well as probes of primordial black holes as
dark matter.
I examine the impact that such an interaction would have through both linear perturbation theory and
nonlinear N-body simulations. I present limits on the possible interaction strength from cosmic
microwave background, large scale structure, and galaxy population data, as well as forecasts on the
future sensitivity. I provide an analysis of what is necessary to distinguish the cosmological impact of
interacting dark matter from similar effects. Intensity mapping of the 21 cm line of neutral hydrogen at
high redshift using next generation observatories, such as the SKA, would provide the strongest
constraints yet on such interactions, and may be able to distinguish between different scenarios
causing suppressed small scale structure. I also present a novel type of probe of structure formation,
using the cosmological gravitational wave signal of high redshift compact binary mergers to provide
information about structure formation, and thus the behaviour of dark matter. Such observations
would also provide competitive constraints.
Finally, I investigate primordial black holes as an alternative dark matter candidate, presenting an
analysis and framework for the evolution of extended mass populations over cosmological time and
computing the present day gamma ray signal, as well as the allowed local evaporation rate. This is
used to set constraints on the allowed population of low mass primordial black holes, and the
likelihood of witnessing an evaporation
Swift: A modern highly-parallel gravity and smoothed particle hydrodynamics solver for astrophysical and cosmological applications
Numerical simulations have become one of the key tools used by theorists in
all the fields of astrophysics and cosmology. The development of modern tools
that target the largest existing computing systems and exploit state-of-the-art
numerical methods and algorithms is thus crucial. In this paper, we introduce
the fully open-source highly-parallel, versatile, and modular coupled
hydrodynamics, gravity, cosmology, and galaxy-formation code Swift. The
software package exploits hybrid task-based parallelism, asynchronous
communications, and domain-decomposition algorithms based on balancing the
workload, rather than the data, to efficiently exploit modern high-performance
computing cluster architectures. Gravity is solved for using a
fast-multipole-method, optionally coupled to a particle mesh solver in Fourier
space to handle periodic volumes. For gas evolution, multiple modern flavours
of Smoothed Particle Hydrodynamics are implemented. Swift also evolves
neutrinos using a state-of-the-art particle-based method. Two complementary
networks of sub-grid models for galaxy formation as well as extensions to
simulate planetary physics are also released as part of the code. An extensive
set of output options, including snapshots, light-cones, power spectra, and a
coupling to structure finders are also included. We describe the overall code
architecture, summarize the consistency and accuracy tests that were performed,
and demonstrate the excellent weak-scaling performance of the code using a
representative cosmological hydrodynamical problem with billion
particles. The code is released to the community alongside extensive
documentation for both users and developers, a large selection of example test
problems, and a suite of tools to aid in the analysis of large simulations run
with Swift.Comment: 39 pages, 18 figures, submitted to MNRAS. Code, documentation, and
examples available at www.swiftsim.co
Recommended from our members
Sonic heritage: listening to the past
History is so often told through objects, images and photographs, but the potential of sounds to reveal place and space is often neglected. Our research project ‘Sonic Palimpsest’1 explores the potential of sound to evoke impressions and new understandings of the past, to embrace the sonic as a tool to understand what was, in a way that can complement and add to our predominant visual understandings. Our work includes the expansion of the Oral History archives held at Chatham Dockyard to include women’s voices and experiences, and the creation of sonic works to engage the public with their heritage. Our research highlights the social and cultural value of oral history and field recordings in the transmission of knowledge to both researchers and the public. Together these recordings document how buildings and spaces within the dockyard were used and experienced by those who worked there. We can begin to understand the social and cultural roles of these buildings within the community, both past and present
METROPOLITAN ENCHANTMENT AND DISENCHANTMENT. METROPOLITAN ANTHROPOLOGY FOR THE CONTEMPORARY LIVING MAP CONSTRUCTION
We can no longer interpret the contemporary metropolis as we did in the last century. The thought of civil economy regarding the contemporary Metropolis conflicts more or less radically with the merely acquisitive dimension of the behaviour of its citizens. What is needed is therefore a new capacity for
imagining the economic-productive future of the city: hybrid social enterprises, economically sustainable, structured and capable of using technologies, could be a solution for producing value and distributing it fairly and inclusively.
Metropolitan Urbanity is another issue to establish. Metropolis needs new spaces where inclusion can occur, and where a repository of the imagery can be recreated. What is the ontology behind the technique of metropolitan planning and management, its vision and its symbols? Competitiveness,
speed, and meritocracy are political words, not technical ones. Metropolitan Urbanity is the characteristic of a polis that expresses itself in its public places. Today, however, public places are private ones that are destined for public use. The Common Good has always had a space of representation in the city, which was the public space. Today, the Green-Grey Infrastructure is the metropolitan city's monument that communicates a value for future generations and must therefore be recognised and imagined; it is the production of the metropolitan symbolic imagery, the new magic of the city
Cyber-Human Systems, Space Technologies, and Threats
CYBER-HUMAN SYSTEMS, SPACE TECHNOLOGIES, AND THREATS is our eighth textbook in a series covering the world of UASs / CUAS/ UUVs / SPACE. Other textbooks in our series are Space Systems Emerging Technologies and Operations; Drone Delivery of CBNRECy – DEW Weapons: Emerging Threats of Mini-Weapons of Mass Destruction and Disruption (WMDD); Disruptive Technologies with applications in Airline, Marine, Defense Industries; Unmanned Vehicle Systems & Operations On Air, Sea, Land; Counter Unmanned Aircraft Systems Technologies and Operations; Unmanned Aircraft Systems in the Cyber Domain: Protecting USA’s Advanced Air Assets, 2nd edition; and Unmanned Aircraft Systems (UAS) in the Cyber Domain Protecting USA’s Advanced Air Assets, 1st edition. Our previous seven titles have received considerable global recognition in the field. (Nichols & Carter, 2022) (Nichols, et al., 2021) (Nichols R. K., et al., 2020) (Nichols R. , et al., 2020) (Nichols R. , et al., 2019) (Nichols R. K., 2018) (Nichols R. K., et al., 2022)https://newprairiepress.org/ebooks/1052/thumbnail.jp
The Fifteenth Marcel Grossmann Meeting
The three volumes of the proceedings of MG15 give a broad view of all aspects of gravitational physics and astrophysics, from mathematical issues to recent observations and experiments. The scientific program of the meeting included 40 morning plenary talks over 6 days, 5 evening popular talks and nearly 100 parallel sessions on 71 topics spread over 4 afternoons. These proceedings are a representative sample of the very many oral and poster presentations made at the meeting.Part A contains plenary and review articles and the contributions from some parallel sessions, while Parts B and C consist of those from the remaining parallel sessions. The contents range from the mathematical foundations of classical and quantum gravitational theories including recent developments in string theory, to precision tests of general relativity including progress towards the detection of gravitational waves, and from supernova cosmology to relativistic astrophysics, including topics such as gamma ray bursts, black hole physics both in our galaxy and in active galactic nuclei in other galaxies, and neutron star, pulsar and white dwarf astrophysics. Parallel sessions touch on dark matter, neutrinos, X-ray sources, astrophysical black holes, neutron stars, white dwarfs, binary systems, radiative transfer, accretion disks, quasars, gamma ray bursts, supernovas, alternative gravitational theories, perturbations of collapsed objects, analog models, black hole thermodynamics, numerical relativity, gravitational lensing, large scale structure, observational cosmology, early universe models and cosmic microwave background anisotropies, inhomogeneous cosmology, inflation, global structure, singularities, chaos, Einstein-Maxwell systems, wormholes, exact solutions of Einstein's equations, gravitational waves, gravitational wave detectors and data analysis, precision gravitational measurements, quantum gravity and loop quantum gravity, quantum cosmology, strings and branes, self-gravitating systems, gamma ray astronomy, cosmic rays and the history of general relativity
Review of Particle Physics
The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 2,143
new measurements from 709 papers, we list, evaluate, and average measured properties of gauge bosons and the
recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical
particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. Particle properties and search
limits are listed in Summary Tables. We give numerous tables, figures, formulae, and reviews of topics such as Higgs
Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology,
Particle Detectors, Colliders, Probability and Statistics. Among the 120 reviews are many that are new or heavily
revised, including a new review on Machine Learning, and one on Spectroscopy of Light Meson Resonances.
The Review is divided into two volumes. Volume 1 includes the Summary Tables and 97 review articles. Volume
2 consists of the Particle Listings and contains also 23 reviews that address specific aspects of the data presented
in the Listings.
The complete Review (both volumes) is published online on the website of the Particle Data Group (pdg.lbl.gov)
and in a journal. Volume 1 is available in print as the PDG Book. A Particle Physics Booklet with the Summary
Tables and essential tables, figures, and equations from selected review articles is available in print, as a web version
optimized for use on phones, and as an Android app.United States Department of Energy (DOE) DE-AC02-05CH11231government of Japan (Ministry of Education, Culture, Sports, Science and Technology)Istituto Nazionale di Fisica Nucleare (INFN)Physical Society of Japan (JPS)European Laboratory for Particle Physics (CERN)United States Department of Energy (DOE
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