The Parallelism Motifs of Genomic Data Analysis

Genomic data sets are growing dramatically as the cost of sequencing continues to decline and small sequencing devices become available. Enormous community databases store and share this data with the research community, but some of these genomic data analysis problems require large scale computational platforms to meet both the memory and computational requirements. These applications differ from scientific simulations that dominate the workload on high end parallel systems today and place different requirements on programming support, software libraries, and parallel architectural design. For example, they involve irregular communication patterns such as asynchronous updates to shared data structures. We consider several problems in high performance genomics analysis, including alignment, profiling, clustering, and assembly for both single genomes and metagenomes. We identify some of the common computational patterns or motifs that help inform parallelization strategies and compare our motifs to some of the established lists, arguing that at least two key patterns, sorting and hashing, are missing

Graph Summarization

The continuous and rapid growth of highly interconnected datasets, which are both voluminous and complex, calls for the development of adequate processing and analytical techniques. One method for condensing and simplifying such datasets is graph summarization. It denotes a series of application-specific algorithms designed to transform graphs into more compact representations while preserving structural patterns, query answers, or specific property distributions. As this problem is common to several areas studying graph topologies, different approaches, such as clustering, compression, sampling, or influence detection, have been proposed, primarily based on statistical and optimization methods. The focus of our chapter is to pinpoint the main graph summarization methods, but especially to focus on the most recent approaches and novel research trends on this topic, not yet covered by previous surveys.Comment: To appear in the Encyclopedia of Big Data Technologie