Towards breast tomography with synchrotron radiation at Elettra: First images

The aim of the SYRMA-CT collaboration is to set-up the first clinical trial of phase-contrast breast CT with synchrotron radiation (SR). In order to combine high image quality and low delivered dose a number of innovative elements are merged: a CdTe single photon counting detector, state-of-the-art CT reconstruction and phase retrieval algorithms. To facilitate an accurate exam optimization, a Monte Carlo model was developed for dose calculation using GEANT4. In this study, high isotropic spatial resolution (120 μm)3 CT scans of objects with dimensions and attenuation similar to a human breast were acquired, delivering mean glandular doses in the range of those delivered in clinical breast CT (5-25 mGy). Due to the spatial coherence of the SR beam and the long distance between sample and detector, the images contain, not only absorption, but also phase information from the samples. The application of a phase-retrieval procedure increases the contrast-to-noise ratio of the tomographic images, while the contrast remains almost constant. After applying the simultaneous algebraic reconstruction technique to low-dose phase-retrieved data sets (about 5 mGy) with a reduced number of projections, the spatial resolution was found to be equal to filtered back projection utilizing a four fold higher dose, while the contrast-to-noise ratio was reduced by 30%. These first results indicate the feasibility of clinical breast CT with SR

Selectiveâ diffusion regularization for enhancement of microcalcifications in digital breast tomosynthesis reconstruction

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134765/1/mp5851.pd

Latest developments in the improvement and quantification of high resolution X-ray tomography data

X-ray Computed Tomography (CT) is a powerful tool to visualize the internal structure of objects. Although X-ray CT is often used for medical purposes, it has many applications in the academic and industrial world. X-ray CT is a non destructive tool which provides the possibility to obtain a three dimensional (3D) representation of the investigated object. The currently available high resolution systems can achieve resolutions of less than one micrometer which makes it a valuable technique for various scientific and industrial applications. At the Centre for X-ray Tomography of the Ghent University (UGCT) research is performed on the improvement and application of high resolution X-ray CT (µCT). Important aspects of this research are the development of state of the art high resolution CT scanners and the development of software for controlling the scanners, reconstruction software and analysis software. UGCT works closely together with researchers from various research fields and each of them have their specific requirements. To obtain the best possible results in any particular case, the scanners are developed in a modular way, which allows for optimizations, modifications and improvements during use. Another way of improving the image quality lies in optimization of the reconstruction software, which is why the software package Octopus was developed in house. Once a scanned volume is reconstructed, an important challenge lies in the interpretation of the obtained data. For this interpretation visualization alone is often insufficient and quantitative information is needed. As researchers from different fields have different needs with respect to quantification of their data, UGCT developed the 3D software analysis package Morpho+ for analysing all kinds of samples. The research presented in this work focuses on improving the accuracy and extending the amount of the quantitative information which can be extracted from µCT data. Even if a perfect analysis algorithm would exist, it would be impossible to accurately quantify data of which the image quality is insufficient. As image quality can significantly be improved with the aid of adequate reconstruction techniques, the research presented in this work focuses on analysis as well as reconstruction software. As the datasets obtained with µCT at UGCT are of substantial size, the possibility to process large datasets in a limited amount of time is crucial in the development of new algorithms. The contributions of the author can be subdivided in three major aspects of the processing of CT data: The modification of iterative reconstruction algorithms, the extension and optimization of 3D analysis algorithms and the development of a new algorithm for discrete tomography. These topics are discussed in more detail below. A main aspect in the improvement of image quality is the reduction of artefacts which often occur in µCT such as noise-, cone beam- and beam hardening artefacts. Cone beam artefacts are a result of the cone beam geometry which is often used in laboratory based µCT and beam hardening is a consequence of the polychromaticity of the beam. Although analytical reconstruction algorithms based on filtered back projection are still most commonly used for the reconstruction of µCT datasets, there is another approach which is becoming a valuable alternative: iterative reconstruction algorithms. Iterative algorithms are inherently better at coping with the previously mentioned artefacts. Additionally iterative algorithms can improve image quality in case the number of available projections or the angular range is limited. In chapter 3 the possibility to modify these algorithms to further improve image quality is investigated. It is illustrated that streak artefacts which can occur when metals are present in a sample can be significantly reduced by modifying the reconstruction algorithm. Additionally, it is demonstrated that the incorporation of an initial solution (if available) allows reducing the required number of projections for a second slightly modified sample. To reduce beam hardening artefacts, the physics of the process is modelled and incorporated in the iterative reconstruction algorithm, which results in an easy to use and efficient algorithm for the reduction of beam hardening artefacts and requires no prior knowledge about the sample. In chapter 4 the 3D analysis process is described. In the scope of this work, algorithms of the 3D-analysis software package Morpho+ were optimized and new methods were added to the program, focusing on quantifying connectivity and shape of the phases and elements in the sample, as well as obtaining accurate segmentation, which is essential step in the analysis process is the segmentation of the reconstructed sample. Evidently, the different phases in the sample need to be separated from one another. However, often a second segmentation step is needed in order to separate the different elements present in a volume, such as pores in a pore network, or to separate elements which are physically separated but appear to be connected on the reconstructed images to limited resolution and/or limited contrast of the scan. The latter effect often occurs in the process of identifying different grains in a geological sample. Algorithms which are available for this second segmentation step often result in over-segmentation, i.e. elements are not only separated from one another but also separations inside a single element occur. To overcome this effect an algorithm is presented to semi-automically rejoin the separated parts of a single element. Additionally, Morpho+ was extended with tools to extract information about the connectivity of a sample, which is difficult to quantify but important for samples from various research fields. The connectivity can be described with the aid of the calculation of the Euler Number and tortuosity. Moreover, the number of neighbouring objects of each object can be determined and the connections between objects can be quantified. It is now also possible to extract a skeleton, which describes the basic structure of the volume. A calculation of several shape parameters was added to the program as well, resulting in the possibility to visualize the different objects on a disc-rod diagram. The many possibilities to characterize reconstructed samples with the aid of Morpho+ are illustrated on several applications. As mentioned in the previous section, an important aspect for correctly quantifying µCT data is the correct segmentation of the different phases present in the sample. Often it is the case that a sample consists of only one or a limited number of materials (and surrounding air). In this case this prior knowledge about the sample can be incorporated in the reconstruction algorithm. These kind of algorithms are referred to as discrete reconstruction algorithms, which are used when only a limited number of projections is available. Chapter 5 deals with discrete reconstruction algorithms. One of these algorithms is the Discrete Algebraic Reconstruction Technique, which combines iterative with discrete reconstruction and has shown excellent results. DART requires knowledge about the attenuation coefficient(s) and segmentation threshold(s) of the material(s). For µCT applications (resulting in large datasets) reconstruction times can significantly increase when DART is used in comparison with standard iterative reconstruction, as DART requires more iterations. This complicates the practical applicability of DART for routine applications at UGCT. Therefore a modified algorithm (based on the DART algorithm) for reconstruction of samples consisting out of only one material and surrounding air was developed in the scope of this work, which is referred to as the Experimental Discrete Algebraic Reconstruction Technique (EDART). The goal of this algorithm is to obtain better reconstruction results in comparison with standard iterative reconstruction algorithms, without significantly increasing reconstruction time. Moreover, a fast and intuitive technique to estimate the attenuation coefficient and threshold was developed as a part of the EDART algorithm. In chapter 5 it is illustrated that EDART provides improved image quality for both phantom and real data, in comparison with standard iterative reconstruction algorithms, when only a limited number of projections is available. The algorithms presented in this work can be subsequently applied but can also be combined with one another. It is for example illustrated in chapter 5 that the beam hardening correction method can also be incorporated in the EDART algorithm. The combination of the introduced methods allows for an improvement in the process of extracting accurate quantitative information from µCT data