14,373 research outputs found

    Factor IX San Dimas. Substitution of glutamine for Arg-4 in the propeptide leads to incomplete gamma-carboxylation and altered phospholipid binding properties.

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    DNA sequence analysis of the Factor IX gene from a hemophilia B patient (98% Factor IX antigen; less than 0.01 unit/ml clotting activity) has identified a point mutation in exon II. A guanine to adenine transition causes the substitution of a glutamine codon for an arginine codon at -4 in the propeptide of Factor IX. This variant, termed Factor IX San Dimas, circulates in the plasma as proFactor IX with a mutant 18-amino acid propeptide still attached. Like Factor IX Cambridge (Arg-1----Ser), Factor IX San Dimas is unable to express metal-induced epitopes recognized by conformation-specific polyclonal antibodies. Amino acid analysis of the alkaline hydrolysate indicates that purified Factor IX San Dimas contains a reduced number of gamma-carboxyglutamyl residues compared to Factor IX. However, this protein undergoes metal-induced quenching of the intrinsic fluorescence. In addition, Factor IX San Dimas is unable to interact with phospholipid vesicles. The absence of coagulant activity in Factor IX San Dimas can be attributed to impaired calcium-induced conformational changes and loss in the ability to bind phospholipid vesicles in the presence of calcium ions

    San Dimas city council discussing SB 54

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    Notes From the Archives: Preserving Sister Aimee's Story The Foursquare Heritage Archives

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    After the 2016 meeting of the Society for Pentecostal Studies in San Dimas, California, the Canadian Journal of Pentecostal-Charismatic Christianity editors agreed that a feature in our continuing "Notes from the Archives" series focusing on the Foursquare Heritage Archives would be of great interest to the journal's readers. Linda Ambrose corresponded with Foursquare Archivist Steve Zeleny, and what follows is a result of their exchange

    Strong motion earthquake accelerograms, digitized and plotted data, Volume I - Uncorrected accelerograms; Part W - Accelerograms IW334 through IW 354

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    This issue, Part W, contains data from the Lytle Creek, California, earthquake of September 12, 1970, and includes three records each from the buildings at 945 Tiverton and 120 N. Robertson in Los Angeles; two records each from the Hollywood Storage Building in Los Angeles, J. P. L. and the Millikan Library in Pasadena, and the Cedar Springs CWR site; and single records from Wrightwood, Devil's Canyon and the Hall of Records in San Bernardino, Colton, Puddingstone Dam in San Dimas, Santa Anita Dam in Arcadia, and the Old Ridge Route in Castaic

    Strong motion earthquake accelerograms, digitized and plotted data, Volume II - corrected accelerograms and integrated ground velocity and displacement curves; Parts O and P - Accelerograms IIO198 to IIO201, IIO204 to IIO208, IIO210, IIO213, IIP214 to ...

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    This issue, Volume II, Parts O and P, Report No. EERL 74-55, continues with the accelerograms obtained during the San Fernando earthquake of February 9, 1971, and includes three records each from the buildings at 1625 Olympic Boulevard, 4867 Sunset Boulevard, and 3345 Wilshire Boulevard in Los Angeles; two records from the building at 9841 Airport Boulevard in Los Angeles; and one record each from the Griffith Park Observatory in Los Angeles, the Utilities Building at 215 W. Broadway, and Terminal Island, both in Long Beach, the Hall of Records in San Bernardino, the Fairmont Reservoir, the University of California at Santa Barbara, the Hemet Fire Station in Hemet, the 1215 Gallery at Hoover Dam, 666 W. 19th Street in Costa Mesa, the Santa Anita Reservoir in Arcadia, the Navy Laboratory at Port Hueneme, and the Puddingstone Reservoir at San Dimas

    W97-1227. Benes II, Louis H. (1906-1978). Papers, 1927-1977. 1.50 linear ft.

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    Western Theological Seminary class of 1930; minister of the Reformed Church in America, 1930‑1945; editor of the Church Herald, 1945‑1974; president of General Synod, 1976‑1977. Papers include bound class notes from Western Theological Seminary courses in English Bible and Old Testament History, correspondence, much of it regarding the “San Dimas Affair,” his retirement and appreciation for his work as editor. Articles relating to his doctorate, lectures, and his great-grandfather’s hymnal, 1846 (Dutch). Correspondents include Albertus Pieters and Gordon Van Wylen

    California Community Foundation 2011 Annual Report

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    Contains messages from the board chair and president, 2010-11 program highlights, grants lists, lists of funds and Legacy Society members, financial summary, and lists of board members, staff, and volunteers

    Spartan Daily, January 30, 2019

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    Volume 152, Issue 3https://scholarworks.sjsu.edu/spartan_daily_2019/1002/thumbnail.jp

    Attracting redevelopment in “inner-ring” municipalities of U.S. metropolitan areas – focusing on Los Angeles and Boston

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    This paper examines the underlying socio-economic conditions that are likely to explain redevelopment activity in the “inner-ring” municipalities of a metropolitan area. The area of study consists of 54 municipalities within Los Angeles county limits and 33 municipalities in the Boston metropolitan area. The time length covered is from 1970 through 2000, focusing on the rate of change in socioeconomic and development conditions from 1970 to 2000 and 1980 to 2000. Among the selected municipalities for the two metropolitan areas, we focused on two groupings based on income - those with median household income within the 20th – 50th percentile and those within the 51st – 100 percentile. The results indicate that local socioeconomic conditions appear to have greater impact on property values in the Los Angeles area than in Boston. Although, new residential activity seems to be influenced by socioeconomic trends in Los Angeles, the empirical analysis in both cities indicates that other factors, such as public incentives, may impact new development activity more significantly.
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