Scaling Up Large-scale Sparse Learning and Its Application to Medical Imaging

abstract: Large-scale $\ell_1$-regularized loss minimization problems arise in high-dimensional applications such as compressed sensing and high-dimensional supervised learning, including classification and regression problems. In many applications, it remains challenging to apply the sparse learning model to large-scale problems that have massive data samples with high-dimensional features. One popular and promising strategy is to scaling up the optimization problem in parallel. Parallel solvers run multiple cores on a shared memory system or a distributed environment to speed up the computation, while the practical usage is limited by the huge dimension in the feature space and synchronization problems. In this dissertation, I carry out the research along the direction with particular focuses on scaling up the optimization of sparse learning for supervised and unsupervised learning problems. For the supervised learning, I firstly propose an asynchronous parallel solver to optimize the large-scale sparse learning model in a multithreading environment. Moreover, I propose a distributed framework to conduct the learning process when the dataset is distributed stored among different machines. Then the proposed model is further extended to the studies of risk genetic factors for Alzheimer's Disease (AD) among different research institutions, integrating a group feature selection framework to rank the top risk SNPs for AD. For the unsupervised learning problem, I propose a highly efficient solver, termed Stochastic Coordinate Coding (SCC), scaling up the optimization of dictionary learning and sparse coding problems. The common issue for the medical imaging research is that the longitudinal features of patients among different time points are beneficial to study together. To further improve the dictionary learning model, I propose a multi-task dictionary learning method, learning the different task simultaneously and utilizing shared and individual dictionary to encode both consistent and changing imaging features.Dissertation/ThesisDoctoral Dissertation Computer Science 201

DRAC: Diabetic Retinopathy Analysis Challenge with Ultra-Wide Optical Coherence Tomography Angiography Images

Computer-assisted automatic analysis of diabetic retinopathy (DR) is of great importance in reducing the risks of vision loss and even blindness. Ultra-wide optical coherence tomography angiography (UW-OCTA) is a non-invasive and safe imaging modality in DR diagnosis system, but there is a lack of publicly available benchmarks for model development and evaluation. To promote further research and scientific benchmarking for diabetic retinopathy analysis using UW-OCTA images, we organized a challenge named "DRAC - Diabetic Retinopathy Analysis Challenge" in conjunction with the 25th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2022). The challenge consists of three tasks: segmentation of DR lesions, image quality assessment and DR grading. The scientific community responded positively to the challenge, with 11, 12, and 13 teams from geographically diverse institutes submitting different solutions in these three tasks, respectively. This paper presents a summary and analysis of the top-performing solutions and results for each task of the challenge. The obtained results from top algorithms indicate the importance of data augmentation, model architecture and ensemble of networks in improving the performance of deep learning models. These findings have the potential to enable new developments in diabetic retinopathy analysis. The challenge remains open for post-challenge registrations and submissions for benchmarking future methodology developments

Towards Integration of Artificial Intelligence into Medical Devices as a Real-Time Recommender System for Personalised Healthcare:State-of-the-Art and Future Prospects

In the era of big data, artificial intelligence (AI) algorithms have the potential to revolutionize healthcare by improving patient outcomes and reducing healthcare costs. AI algorithms have frequently been used in health care for predictive modelling, image analysis and drug discovery. Moreover, as a recommender system, these algorithms have shown promising impacts on personalized healthcare provision. A recommender system learns the behaviour of the user and predicts their current preferences (recommends) based on their previous preferences. Implementing AI as a recommender system improves this prediction accuracy and solves cold start and data sparsity problems. However, most of the methods and algorithms are tested in a simulated setting which cannot recapitulate the influencing factors of the real world. This review article systematically reviews prevailing methodologies in recommender systems and discusses the AI algorithms as recommender systems specifically in the field of healthcare. It also provides discussion around the most cutting-edge academic and practical contributions present in the literature, identifies performance evaluation matrices, challenges in the implementation of AI as a recommender system, and acceptance of AI-based recommender systems by clinicians. The findings of this article direct researchers and professionals to comprehend currently developed recommender systems and the future of medical devices integrated with real-time recommender systems for personalized healthcare

Deep Learning Techniques for Power System Operation: Modeling and Implementation

The fast development of the deep learning (DL) techniques in the most recent years has drawn attention from both academia and industry. And there have been increasing applications of the DL techniques in many complex real-world situations, including computer vision, medical diagnosis, and natural language processing. The great power and flexibility of DL can be attributed to its hierarchical learning structure that automatically extract features from mass amounts of data. In addition, DL applies an end-to-end solving mechanism, and directly generates the output from the input, where the traditional machine learning methods usually break down the problem and combine the results. The end-to-end mechanism considerably improve the computational efficiency of the DL.The power system is one of the most complex artificial infrastructures, and many power system control and operation problems share the same features as the above mentioned real-world applications, such as time variability and uncertainty, partial observability, which impedes the performance of the conventional model-based methods. On the other hand, with the wide spread implementation of Advanced Metering Infrastructures (AMI), the SCADA, the Wide Area Monitoring Systems (WAMS), and many other measuring system providing massive data from the field, the data-driven deep learning technique is becoming an intriguing alternative method to enable the future development and success of the smart grid. This dissertation aims to explore the potential of utilizing the deep-learning-based approaches to solve a broad range of power system modeling and operation problems. First, a comprehensive literature review is conducted to summarize the existing applications of deep learning techniques in power system area. Second, the prospective application of deep learning techniques in several scenarios in power systems, including contingency screening, cascading outage search, multi-microgrid energy management, residential HVAC system control, and electricity market bidding are discussed in detail in the following 2-6 chapters. The problem formulation, the specific deep learning approaches in use, and the simulation results are all presented, and also compared with the currently used model-based method as a verification of the advantage of deep learning. Finally, the conclusions are provided in the last chapter, as well as the directions for future researches. It’s hoped that this dissertation can work as a single spark of fire to enlighten more innovative ideas and original studies, widening and deepening the application of deep learning technique in the field of power system, and eventually bring some positive impacts to the real-world bulk grid resilient and economic control and operation

Automated analysis of feature models: Quo vadis?

Feature models have been used since the 90's to describe software product lines as a way of reusing common parts in a family of software systems. In 2010, a systematic literature review was published summarizing the advances and settling the basis of the area of Automated Analysis of Feature Models (AAFM). From then on, different studies have applied the AAFM in different domains. In this paper, we provide an overview of the evolution of this field since 2010 by performing a systematic mapping study considering 423 primary sources. We found six different variability facets where the AAFM is being applied that define the tendencies: product configuration and derivation; testing and evolution; reverse engineering; multi-model variability-analysis; variability modelling and variability-intensive systems. We also confirmed that there is a lack of industrial evidence in most of the cases. Finally, we present where and when the papers have been published and who are the authors and institutions that are contributing to the field. We observed that the maturity is proven by the increment in the number of journals published along the years as well as the diversity of conferences and workshops where papers are published. We also suggest some synergies with other areas such as cloud or mobile computing among others that can motivate further research in the future.Ministerio de Economía y Competitividad TIN2015-70560-RJunta de Andalucía TIC-186