1,046 research outputs found

    Medical Image Analysis using Deep Relational Learning

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    In the past ten years, with the help of deep learning, especially the rapid development of deep neural networks, medical image analysis has made remarkable progress. However, how to effectively use the relational information between various tissues or organs in medical images is still a very challenging problem, and it has not been fully studied. In this thesis, we propose two novel solutions to this problem based on deep relational learning. First, we propose a context-aware fully convolutional network that effectively models implicit relation information between features to perform medical image segmentation. The network achieves the state-of-the-art segmentation results on the Multi Modal Brain Tumor Segmentation 2017 (BraTS2017) and Multi Modal Brain Tumor Segmentation 2018 (BraTS2018) data sets. Subsequently, we propose a new hierarchical homography estimation network to achieve accurate medical image mosaicing by learning the explicit spatial relationship between adjacent frames. We use the UCL Fetoscopy Placenta dataset to conduct experiments and our hierarchical homography estimation network outperforms the other state-of-the-art mosaicing methods while generating robust and meaningful mosaicing result on unseen frames.Comment: arXiv admin note: substantial text overlap with arXiv:2007.0778

    Artificial Intelligence: Development and Applications in Neurosurgery

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    The last decade has witnessed a significant increase in the relevance of artificial intelligence (AI) in neuroscience. Gaining notoriety from its potential to revolutionize medical decision making, data analytics, and clinical workflows, AI is poised to be increasingly implemented into neurosurgical practice. However, certain considerations pose significant challenges to its immediate and widespread implementation. Hence, this chapter will explore current developments in AI as it pertains to the field of clinical neuroscience, with a primary focus on neurosurgery. Additionally included is a brief discussion of important economic and ethical considerations related to the feasibility and implementation of AI-based technologies in neurosciences, including future horizons such as the operational integrations of human and non-human capabilities

    On the Utility of Representation Learning Algorithms for Myoelectric Interfacing

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    Electrical activity produced by muscles during voluntary movement is a reflection of the firing patterns of relevant motor neurons and, by extension, the latent motor intent driving the movement. Once transduced via electromyography (EMG) and converted into digital form, this activity can be processed to provide an estimate of the original motor intent and is as such a feasible basis for non-invasive efferent neural interfacing. EMG-based motor intent decoding has so far received the most attention in the field of upper-limb prosthetics, where alternative means of interfacing are scarce and the utility of better control apparent. Whereas myoelectric prostheses have been available since the 1960s, available EMG control interfaces still lag behind the mechanical capabilities of the artificial limbs they are intended to steer—a gap at least partially due to limitations in current methods for translating EMG into appropriate motion commands. As the relationship between EMG signals and concurrent effector kinematics is highly non-linear and apparently stochastic, finding ways to accurately extract and combine relevant information from across electrode sites is still an active area of inquiry.This dissertation comprises an introduction and eight papers that explore issues afflicting the status quo of myoelectric decoding and possible solutions, all related through their use of learning algorithms and deep Artificial Neural Network (ANN) models. Paper I presents a Convolutional Neural Network (CNN) for multi-label movement decoding of high-density surface EMG (HD-sEMG) signals. Inspired by the successful use of CNNs in Paper I and the work of others, Paper II presents a method for automatic design of CNN architectures for use in myocontrol. Paper III introduces an ANN architecture with an appertaining training framework from which simultaneous and proportional control emerges. Paper Iv introduce a dataset of HD-sEMG signals for use with learning algorithms. Paper v applies a Recurrent Neural Network (RNN) model to decode finger forces from intramuscular EMG. Paper vI introduces a Transformer model for myoelectric interfacing that do not need additional training data to function with previously unseen users. Paper vII compares the performance of a Long Short-Term Memory (LSTM) network to that of classical pattern recognition algorithms. Lastly, paper vIII describes a framework for synthesizing EMG from multi-articulate gestures intended to reduce training burden

    Machine learning-based early diagnosis of autism according to eye movements of real and artificial faces scanning

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    BackgroundStudies on eye movements found that children with autism spectrum disorder (ASD) had abnormal gaze behavior to social stimuli. The current study aimed to investigate whether their eye movement patterns in relation to cartoon characters or real people could be useful in identifying ASD children.MethodsEye-tracking tests based on videos of cartoon characters and real people were performed for ASD and typically developing (TD) children aged between 12 and 60 months. A three-level hierarchical structure including participants, events, and areas of interest was used to arrange the data obtained from eye-tracking tests. Random forest was adopted as the feature selection tool and classifier, and the flattened vectors and diagnostic information were used as features and labels. A logistic regression was used to evaluate the impact of the most important features.ResultsA total of 161 children (117 ASD and 44 TD) with a mean age of 39.70 ± 12.27 months were recruited. The overall accuracy, precision, and recall of the model were 0.73, 0.73, and 0.75, respectively. Attention to human-related elements was positively related to the diagnosis of ASD, while fixation time for cartoons was negatively related to the diagnosis.ConclusionUsing eye-tracking techniques with machine learning algorithms might be promising for identifying ASD. The value of artificial faces, such as cartoon characters, in the field of ASD diagnosis and intervention is worth further exploring

    Autonomous Radar-based Gait Monitoring System

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    Features related to gait are fundamental metrics of human motion [1]. Human gait has been shown to be a valuable and feasible clinical marker to determine the risk of physical and mental functional decline [2], [3]. Technologies that detect changes in people’s gait patterns, especially older adults, could support the detection, evaluation, and monitoring of parameters related to changes in mobility, cognition, and frailty. Gait assessment has the potential to be leveraged as a clinical measurement as it is not limited to a specific health care discipline and is a consistent and sensitive test [4]. A wireless technology that uses electromagnetic waves (i.e., radar) to continually measure gait parameters at home or in a hospital without a clinician’s participation has been proposed as a suitable solution [3], [5]. This approach is based on the interaction between electromagnetic waves with humans and how their bodies impact the surrounding and scattered wireless signals. Since this approach uses wireless waves, people do not need to wear or carry a device on their bodies. Additionally, an electromagnetic wave wireless sensor has no privacy issues because there is no video-based camera. This thesis presents the design and testing of a radar-based contactless system that can monitor people’s gait patterns and recognize their activities in a range of indoor environments frequently and accurately. In this thesis, the use of commercially available radars for gait monitoring is investigated, which offers opportunities to implement unobtrusive and contactless gait monitoring and activity recognition. A novel fast and easy-to-implement gait extraction algorithm that enables an individual’s spatiotemporal gait parameter extraction at each gait cycle using a single FMCW (Frequency Modulated Continuous Wave) radar is proposed. The proposed system detects changes in gait that may be the signs of changes in mobility, cognition, and frailty, particularly for older adults in individual’s homes, retirement homes and long-term care facilities retirement homes. One of the straightforward applications for gait monitoring using radars is in corridors and hallways, which are commonly available in most residential homes, retirement, and long-term care homes. However, walls in the hallway have a strong “clutter” impact, creating multipath due to the wide beam of commercially available radar antennas. The multipath reflections could result in an inaccurate gait measurement because gait extraction algorithms employ the assumption that the maximum reflected signals come from the torso of the walking person (rather than indirect reflections or multipath) [6]. To address the challenges of hallway gait monitoring, two approaches were used: (1) a novel signal processing method and (2) modifying the radar antenna using a hyperbolic lens. For the first approach, a novel algorithm based on radar signal processing, unsupervised learning, and a subject detection, association and tracking method is proposed. This proposed algorithm could be paired with any type of multiple-input multiple-output (MIMO) or single-input multiple-output (SIMO) FMCW radar to capture human gait in a highly cluttered environment without needing radar antenna alteration. The algorithm functionality was validated by capturing spatiotemporal gait values (e.g., speed, step points, step time, step length, and step count) of people walking in a hallway. The preliminary results demonstrate the promising potential of the algorithm to accurately monitor gait in hallways, which increases opportunities for its applications in institutional and home environments. For the second approach, an in-package hyperbola-based lens antenna was designed that can be integrated with a radar module package empowered by the fast and easy-to-implement gait extraction method. The system functionality was successfully validated by capturing the spatiotemporal gait values of people walking in a hallway filled with metallic cabinets. The results achieved in this work pave the way to explore the use of stand-alone radar-based sensors in long hallways for day-to-day long-term monitoring of gait parameters of older adults or other populations. The possibility of the coexistence of multiple walking subjects is high, especially in long-term care facilities where other people, including older adults, might need assistance during walking. GaitRite and wearables are not able to assess multiple people’s gait at the same time using only one device [7], [8]. In this thesis, a novel radar-based algorithm is proposed that is capable of tracking multiple people or extracting walking speed of a participant with the coexistence of other people. To address the problem of tracking and monitoring multiple walking people in a cluttered environment, a novel iterative framework based on unsupervised learning and advanced signal processing was developed and tested to analyze the reflected radio signals and extract walking movements and trajectories in a hallway environment. Advanced algorithms were developed to remove multipath effects or ghosts created due to the interaction between walking subjects and stationary objects, to identify and separate reflected signals of two participants walking at a close distance, and to track multiple subjects over time. This method allows the extraction of walking speed in multiple closely-spaced subjects simultaneously, which is distinct from previous approaches where the speed of only one subject was obtained. The proposed multiple-people gait monitoring was assessed with 22 participants who participated in a bedrest (BR) study conducted at McGill University Health Centre (MUHC). The system functionality also was assessed for in-home applications. In this regard, a cloud-based system is proposed for non-contact, real-time recognition and monitoring of physical activities and walking periods within a domestic environment. The proposed system employs standalone Internet of Things (IoT)-based millimeter wave radar devices and deep learning models to enable autonomous, free-living activity recognition and gait analysis. Range-Doppler maps generated from a dataset of real-life in-home activities are used to train deep learning models. The performance of several deep learning models was evaluated based on accuracy and prediction time, with the gated recurrent network (GRU) model selected for real-time deployment due to its balance of speed and accuracy compared to 2D Convolutional Neural Network Long Short-Term Memory (2D-CNNLSTM) and Long Short-Term Memory (LSTM) models. In addition to recognizing and differentiating various activities and walking periods, the system also records the subject’s activity level over time, washroom use frequency, sleep/sedentary/active/out-of-home durations, current state, and gait parameters. Importantly, the system maintains privacy by not requiring the subject to wear or carry any additional devices

    Tradition and Innovation in Construction Project Management

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    This book is a reprint of the Special Issue 'Tradition and Innovation in Construction Project Management' that was published in the journal Buildings

    Cerebrovascular dysfunction in cerebral small vessel disease

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    INTRODUCTION: Cerebral small vessel disease (SVD) is the cause of a quarter of all ischaemic strokes and is postulated to have a role in up to half of all dementias. SVD pathophysiology remains unclear but cerebrovascular dysfunction may be important. If confirmed many licensed medications have mechanisms of action targeting vascular function, potentially enabling new treatments via drug repurposing. Knowledge is limited however, as most studies assessing cerebrovascular dysfunction are small, single centre, single imaging modality studies due to the complexities in measuring cerebrovascular dysfunctions in humans. This thesis describes the development and application of imaging techniques measuring several cerebrovascular dysfunctions to investigate SVD pathophysiology and trial medications that may improve small blood vessel function in SVD. METHODS: Participants with minor ischaemic strokes were recruited to a series of studies utilising advanced MRI techniques to measure cerebrovascular dysfunction. Specifically MRI scans measured the ability of different tissues in the brain to change blood flow in response to breathing carbon dioxide (cerebrovascular reactivity; CVR) and the flow and pulsatility through the cerebral arteries, venous sinuses and CSF spaces. A single centre observational study optimised and established feasibility of the techniques and tested associations of cerebrovascular dysfunctions with clinical and imaging phenotypes. Then a randomised pilot clinical trial tested two medications’ (cilostazol and isosorbide mononitrate) ability to improve CVR and pulsatility over a period of eight weeks. The techniques were then expanded to include imaging of blood brain barrier permeability and utilised in multi-centre studies investigating cerebrovascular dysfunction in both sporadic and monogenetic SVDs. RESULTS: Imaging protocols were feasible, consistently being completed with usable data in over 85% of participants. After correcting for the effects of age, sex and systolic blood pressure, lower CVR was associated with higher white matter hyperintensity volume, Fazekas score and perivascular space counts. Lower CVR was associated with higher pulsatility of blood flow in the superior sagittal sinus and lower CSF flow stroke volume at the foramen magnum. Cilostazol and isosorbide mononitrate increased CVR in white matter. The CVR, intra-cranial flow and pulsatility techniques, alongside blood brain barrier permeability and microstructural integrity imaging were successfully employed in a multi-centre observational study. A clinical trial assessing the effects of drugs targeting blood pressure variability is nearing completion. DISCUSSION: Cerebrovascular dysfunction in SVD has been confirmed and may play a more direct role in disease pathogenesis than previously established risk factors. Advanced imaging measures assessing cerebrovascular dysfunction are feasible in multi-centre studies and trials. Identifying drugs that improve cerebrovascular dysfunction using these techniques may be useful in selecting candidates for definitive clinical trials which require large sample sizes and long follow up periods to show improvement against outcomes of stroke and dementia incidence and cognitive function

    Artificial Intelligence for Cognitive Health Assessment: State-of-the-Art, Open Challenges and Future Directions

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    The subjectivity and inaccuracy of in-clinic Cognitive Health Assessments (CHA) have led many researchers to explore ways to automate the process to make it more objective and to facilitate the needs of the healthcare industry. Artificial Intelligence (AI) and machine learning (ML) have emerged as the most promising approaches to automate the CHA process. In this paper, we explore the background of CHA and delve into the extensive research recently undertaken in this domain to provide a comprehensive survey of the state-of-the-art. In particular, a careful selection of significant works published in the literature is reviewed to elaborate a range of enabling technologies and AI/ML techniques used for CHA, including conventional supervised and unsupervised machine learning, deep learning, reinforcement learning, natural language processing, and image processing techniques. Furthermore, we provide an overview of various means of data acquisition and the benchmark datasets. Finally, we discuss open issues and challenges in using AI and ML for CHA along with some possible solutions. In summary, this paper presents CHA tools, lists various data acquisition methods for CHA, provides technological advancements, presents the usage of AI for CHA, and open issues, challenges in the CHA domain. We hope this first-of-its-kind survey paper will significantly contribute to identifying research gaps in the complex and rapidly evolving interdisciplinary mental health field

    Mobility classification of cattle with micro-Doppler radar

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    Lameness in dairy cattle is a welfare concern that negatively impacts animal productivity and farmer profitability. Micro-Doppler radar sensing has been previously suggested as a potential system for automating lameness detection in ruminants. This thesis investigates the refinement of the proposed automated system by analysing and enhancing the repeatability and accuracy of the existing scoring method in cattle mobility scoring, used to provide labels in machine learning. The main aims of the thesis were (1) to quantify the performance of the micro-Doppler radar sensing method for the assessment of mobility, (2) to characterise and validate micro-Doppler radar signatures of dairy cattle with varying degrees of gait impairment, and (3) to develop machine learning algorithms that can infer the mobility status of the animals under test from their radar signatures and support automatic contactless classification. The first study investigated inter-assessor agreement using a 4-level system and modifications to it, as well as the impact of factors such as mobility scoring experience, confidence in scoring decisions, and video characteristics. The results revealed low levels of agreement between assessors' scores, with kappa values ranging from 0.16 to 0.53. However, after transforming and reducing the mobility scoring system levels, an improvement was observed, with kappa values ranging from 0.2 to 0.67. Subsequently, a longitudinal study was conducted using good-agreement scores as ground truth labels in supervised machine-learning models. However, the accuracy of the algorithmic models was found to be insufficient, ranging from 0.57 to 0.63. To address this issue, different labelling systems and data pre-processing techniques were explored in a cross-sectional study. Nonetheless, the inter-assessor agreement remained challenging, with an average kappa value of 0.37 (SD = 0.16), and high-accuracy algorithmic predictions remained elusive, with an average accuracy of 56.1 (SD =16.58). Finally, the algorithms' performance was tested with high-confidence labels, which consisted of only scores 0 and 3 of the AHDB system. This testing resulted in good classification accuracy (0.82), specificity (0.79), and sensitivity (0.85). This led to the proposal of a new approach to producing labels, testing vantage point changes, and improving the performance of machine learning models (average accuracy = 0.7 & SD = 0.17, average sensitivity = 0.68 & SD = 0.27, average specificity = 0.75 & SD = 0.17). The research identified a challenge in creating high-confidence diagnostic labels for supervised machine learning-based algorithms to automate the detection and classification of lameness in dairy cows. As a result, the original goals were partially overridden, with the focus shifted to creating reliable labels that would perform well with radar data and machine learning. This point was considered necessary for smooth system development and process automation. Nevertheless, we managed to quantify the performance of the micro-Doppler radar system, partially develop the supervised machine learning algorithms, compare levels of agreement among multiple assessors, evaluate the assessment tools, assess the mobility evaluation process and gather a valuable data set which can be used as a foundation for subsequent studies. Finally, the thesis suggests changes in the assessment process to improve the prediction accuracy of algorithms based on supervised machine learning with radar data

    Graphonomics and your Brain on Art, Creativity and Innovation : Proceedings of the 19th International Graphonomics Conference (IGS 2019 – Your Brain on Art)

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    [Italiano]: “Grafonomia e cervello su arte, creatività e innovazione”. Un forum internazionale per discutere sui recenti progressi nell'interazione tra arti creative, neuroscienze, ingegneria, comunicazione, tecnologia, industria, istruzione, design, applicazioni forensi e mediche. I contributi hanno esaminato lo stato dell'arte, identificando sfide e opportunità, e hanno delineato le possibili linee di sviluppo di questo settore di ricerca. I temi affrontati includono: strategie integrate per la comprensione dei sistemi neurali, affettivi e cognitivi in ambienti realistici e complessi; individualità e differenziazione dal punto di vista neurale e comportamentale; neuroaesthetics (uso delle neuroscienze per spiegare e comprendere le esperienze estetiche a livello neurologico); creatività e innovazione; neuro-ingegneria e arte ispirata dal cervello, creatività e uso di dispositivi di mobile brain-body imaging (MoBI) indossabili; terapia basata su arte creativa; apprendimento informale; formazione; applicazioni forensi. / [English]: “Graphonomics and your brain on art, creativity and innovation”. A single track, international forum for discussion on recent advances at the intersection of the creative arts, neuroscience, engineering, media, technology, industry, education, design, forensics, and medicine. The contributions reviewed the state of the art, identified challenges and opportunities and created a roadmap for the field of graphonomics and your brain on art. The topics addressed include: integrative strategies for understanding neural, affective and cognitive systems in realistic, complex environments; neural and behavioral individuality and variation; neuroaesthetics (the use of neuroscience to explain and understand the aesthetic experiences at the neurological level); creativity and innovation; neuroengineering and brain-inspired art, creative concepts and wearable mobile brain-body imaging (MoBI) designs; creative art therapy; informal learning; education; forensics
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