Heterogeneous Distributed Data Base Management Systems

This work analyzes the design and implementation issues of Heterogeneous Distributed Data Base Management Systems (HDDBMS). To date, HD-DBMS research projects and implementa tions have been limited. The few such systems which have been constructed provide valuable insight into the nature of problems faced due to heterogeneity. Some of these systems (SIRIUS-DELTA, MULTIBASE, AIDA) , are presented in order to examine their solutions to the problems. The major issues described in the thesis are: the architec ture of the distributed system; query translation; schema mapping; and integration of the schemata within the hetero geneous distributed database, in seeking solutions to these issues, an architecture for a HD-DBMS is proposed

Angiotensin type-2 (AT-2)-receptor activation reduces renal fibrosis in cyclosporine nephropathy: evidence for blood-pressure independent effect

Compound 21 (C21), selective agonist of AT2 receptors, shows antinflammatory effects in hypertension and nephroprotection in diabetes. The aim of this study was to evaluate the effects of C21 in cyclosporine nephropathy, which is characterized mainly by tubulo-interstitial fibrosis. Ten days before and during the experimental periods, low-salt diet was administered to Sprague Dawley rats. Cyclosporine-A (15mg/kg/day, i.p.) and cyclosporine-A plus C21 (0.3 mg/kg /day, i.p) were administered for 1 and 4 weeks. Control groups was left without any treatment. Blood pressure (plethysmographic method) and 24 hour albuminuria were measured once a week. At the end of the experiments, the kidneys were excised for histomorphometric analysis of renal fibrosis and for immunohistochemical evaluation of inflammatory infiltrates and type I and IV collagen expression.After 1 and 4 weeks, the rats treated with cyclosporine showed a significant increase (p <0.01) in blood pressure, no significant changes in albuminuria, a significant increase (p <0.01) in glomerular and tubulo-interstitial fibrosis and inflammatory infiltrates as compared to the control rats. Treatment with C21 did not modify the cyclosporine dependent increase of blood pressure, which was higher than in control rats, but after 4 weeks of treatment significantly reduced (p <0.01) glomerular and tubulo-interstitial fibrosis, type 1 collagen expression and macrophage infiltration, as compared to rats treated with cyclosporine.The administration of C21 showed a protective effect on cyclosporine nephropathy, decreasing renal fibrosis and macrophage infiltration. These data suggest that C21 may counteract tubulo-interstitial fibrosis, the most potent predictor of the progression of renal diseases

Digital Radio Strategies in the United States: A Tale of Two Systems

This essay analyzes how, despite early interest in the Digital Audio Broadcasting standard (DAB) in the United States, an alternative in-band system (HD Radio) was developed as the approved digital radio standard

Unmanned Aerial Vehicle (UAV) for monitoring soil erosion in Morocco

This article presents an environmental remote sensing application using a UAV that is specifically aimed at reducing the data gap between field scale and satellite scale in soil erosion monitoring in Morocco. A fixed-wing aircraft type Sirius I (MAVinci, Germany) equipped with a digital system camera (Panasonic) is employed. UAV surveys are conducted over different study sites with varying extents and flying heights in order to provide both very high resolution site-specific data and lower-resolution overviews, thus fully exploiting the large potential of the chosen UAV for multi-scale mapping purposes. Depending on the scale and area coverage, two different approaches for georeferencing are used, based on high-precision GCPs or the UAV’s log file with exterior orientation values respectively. The photogrammetric image processing enables the creation of Digital Terrain Models (DTMs) and ortho-image mosaics with very high resolution on a sub-decimetre level. The created data products were used for quantifying gully and badland erosion in 2D and 3D as well as for the analysis of the surrounding areas and landscape development for larger extents

Metabolic reprogramming promotes myogenesis during aging

Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during aging. Here we studied the link between myogenesis and metabolism. In particular, we analyzed the effect of the metabolic modulator trimetazidine (TMZ) on myogenesis in aging. We show that reprogramming the metabolism by TMZ treatment for 12 consecutive days stimulates myogenic gene expression in skeletal muscle of 22-month-old mice. Our data also reveal that TMZ increases the levels of mitochondrial proteins and stimulates the oxidative metabolism in aged muscles, this finding being in line with our previous observations in cachectic mice. Moreover, we show that, besides TMZ also other types of metabolic modulators (i.e., 5-Aminoimidazole-4-Carboxamide Ribofuranoside-AICAR) can stimulate differentiation of skeletal muscle progenitors in vitro. Overall, our results reveal that reprogramming the metabolism stimulates myogenesis while triggering mitochondrial proteins synthesis in vivo during aging. Together with the previously reported ability of TMZ to increase muscle strength in aged mice, these new data suggest an interesting non-invasive therapeutic strategy which could contribute to improving muscle quality and neuromuscular communication in the elderly, and counteracting sarcopenia

Aspects of the taphonomy of the Cambrian Explosion in North Greenland

This thesis describes and elucidates the taphonomic pathways responsible for the exceptional preservation of some of the most common elements of the Sirius Passet Lagerstätte (early Cambrian), North Greenland. Investigative techniques including cathodoluminescence, are tested first on silicified molluscs from the Oligocene of Antigua, associated with a volcanic source; described in chapter 2. By describing the depositional environment of the Sirius Passet biota in detail and using a combination of analytical techniques such as SEM, EDAX, SEM-CL and elemental mapping two published papers address a number of the key research questions surrounding the unique taphonomic pathways in the Sirius Passet biota and their broader significance in understanding Cambrian ecosystems. The papers are included in the form of chapters 3 and 4 and the published versions included in the appendices. A unique, mat-dominated, tissue specific taphonomic pathway is proposed, more akin to the Proterozoic than the typical Burgess Shale Type (BST) preservation seen elsewhere in the Cambrian. This together with mouldic preservation indicates a range of taphonomic styles concomitant with the range of new biotas at the dawn of the Cambrian Explosion

SemTab 2019: Resources to Benchmark Tabular Data to Knowledge Graph Matching Systems

Tabular data to Knowledge Graph matching is the process of assigning semantic tags from knowledge graphs (e.g., Wikidata or DBpedia) to the elements of a table. This task is a challenging problem for various reasons, including the lack of metadata (e.g., table and column names), the noisiness, heterogeneity, incompleteness and ambiguity in the data. The results of this task provide significant insights about potentially highly valuable tabular data, as recent works have shown, enabling a new family of data analytics and data science applications. Despite significant amount of work on various flavors of this problem, there is a lack of a common framework to conduct a systematic evaluation of state-of-the-art systems. The creation of the Semantic Web Challenge on Tabular Data to Knowledge Graph Matching (SemTab) aims at filling this gap. In this paper, we report about the datasets, infrastructure and lessons learned from the first edition of the SemTab challenge

The effects of climate change and variation in New Zealand: An assessment using the CLIMPACTS system

Along with a need to better understand the climate and biophysical systems of New Zealand, the need to develop an improved capacity for evaluating possible changes in climate and their effects on the New Zealand environment has been recognised. Since the middle of 1993 the CLIMPACTS programme, has been focused on the development of such a capacity, in the first instance for the agricultural sector. the goals of this present assessment are: 1. To present current knowledge on likely scenarios of climate change and associated uncertainties in New Zealand; 2. To present current knowledge, based on quantitative analyses using a consistent set of scenarios, on the likely effects of climate change on a range of agricultural and horticultural crops of economic importance; 3. To demonstrate, by way of this report and the associated technical report, the capacity that has been developed for ongoing assessments of this kind in New Zealand. This report has been prepared for both the science and policy communities in New Zealand. There are two main components: 1. The detailed findings of the assessment, presented in a series of chapters; 2. An annex, which contains technical details on models used in the assessment