Rule responder HCLS eScience infrastructure

paschke at inf.fu-berlin.de The emerging field of integrative bioinformatics provides en-abling methods and technologies for transparent information integration across distributed heterogenous data sources, tools and services. The aim of this article is to evolve a flex-ible and expandable distributed Pragmatic Web eScience infrastructure in the domain of Health Care and Life Sci-ence (HCLS), called Rule Responder HCLS. Rule Respon-der HCLS is about providing information consumers with rule-based agents to transform existing information into rel-evant information of practical consequences, hence provid-ing control to the end-users by enabling them to express in a declarative rule-based way how to turn existing informa-tion into personally relevant information and how to react or make automated decisions on top of it