Filtering for nonlinear genetic regulatory networks with stochastic disturbances

In this paper, the filtering problem is investigated for nonlinear genetic regulatory networks with stochastic disturbances and time delays, where the nonlinear function describing the feedback regulation is assumed to satisfy the sector condition, the stochastic perturbation is in the form of a scalar Brownian motion, and the time delays exist in both the translation process and the feedback regulation process. The purpose of the addressed filtering problem is to estimate the true concentrations of the mRNA and protein. Specifically, we are interested in designing a linear filter such that, in the presence of time delays, stochastic disturbances as well as sector nonlinearities, the filtering dynamics of state estimation for the stochastic genetic regulatory network is exponentially mean square stable with a prescribed decay rate lower bound beta. By using the linear matrix inequality (LMI) technique, sufficient conditions are first derived for ensuring the desired filtering performance for the gene regulatory model, and the filter gain is then characterized in terms of the solution to an LMI, which can be easily solved by using standard software packages. A simulation example is exploited in order to illustrate the effectiveness of the proposed design procedures

Stability analysis of a general class of singularly perturbed linear hybrid systems

Motivated by a real problem in steel production, we introduce and analyze a general class of singularly perturbed linear hybrid systems with both switches and impulses, in which the slow or fast nature of the variables can be mode-dependent. This means that, at switching instants, some of the slow variables can become fast and vice-versa. Firstly, we show that using a mode-dependent variable reordering we can rewrite this class of systems in a form in which the variables preserve their nature over time. Secondly, we establish, through singular perturbation techniques, an upper bound on the minimum dwell-time ensuring the overall system's stability. Remarkably, this bound is the sum of two terms. The first term corresponds to an upper bound on the minimum dwell-time ensuring the stability of the reduced order linear hybrid system describing the slow dynamics. The order of magnitude of the second term is determined by that of the parameter defining the ratio between the two time-scales of the singularly perturbed system. We show that the proposed framework can also take into account the change of dimension of the state vector at switching instants. Numerical illustrations complete our study

Robust normalization and guaranteed cost control for a class of uncertain singular Markovian jump systems via hybrid impulsive control

This paper investigates the problem of robust normalization and guaranteed cost control for a class of uncertain singular Markovian jump systems. The uncertainties exhibit in both system matrices and transition rate matrix of the Markovian chain. A new impulsive and proportional-derivative control strategy is presented, where the derivative gain is to make the closed-loop system of the singular plant to be a normal one, and the impulsive control part is to make the value of the Lyapunov function does not increase at each time instant of the Markovian switching. A linearization approach via congruence transformations is proposed to solve the controller design problem. The cost function is minimized via solving an optimization problem under the designed control scheme. Finally, three examples (two numerical examples and an RC pulse divider circuit example) are provided to illustrate the effectiveness and applicability of the proposed methods

Time-Delay Systems

Time delay is very often encountered in various technical systems, such as electric, pneumatic and hydraulic networks, chemical processes, long transmission lines, robotics, etc. The existence of pure time lag, regardless if it is present in the control or/and the state, may cause undesirable system transient response, or even instability. Consequently, the problem of controllability, observability, robustness, optimization, adaptive control, pole placement and particularly stability and robustness stabilization for this class of systems, has been one of the main interests for many scientists and researchers during the last five decades

Non-fragile H∞ control with randomly occurring gain variations, distributed delays and channel fadings

This study is concerned with the non-fragile H∞ control problem for a class of discrete-time systems subject to randomly occurring gain variations (ROGVs), channel fadings and infinite-distributed delays. A new stochastic phenomenon (ROGVs), which is governed by a sequence of random variables with a certain probabilistic distribution, is put forward to better reflect the reality of the randomly occurring fluctuation of controller gains implemented in networked environments. A modified stochastic Rice fading model is then exploited to account for both channel fadings and random time-delays in a unified representation. The channel coefficients are a set of mutually independent random variables which abide by any (not necessarily Gaussian) probability density function on [0, 1]. Attention is focused on the analysis and design of a non-fragile H∞ outputfeedback controller such that the closed-loop control system is stochastically stable with a prescribed H∞ performance. Through intensive stochastic analysis, sufficient conditions are established for the desired stochastic stability and H∞ disturbance attenuation, and the addressed non-fragile control problem is then recast as a convex optimisation problem solvable via the semidefinite programme method. An example is finally provided to demonstrate the effectiveness of the proposed design method