Linear parameter-varying model to design control laws for an artificial pancreas

The contribution of this work is the generation of a control-oriented model for insulin-glucose dynamic regulation in type 1 diabetes mellitus (T1DM). The novelty of this model is that it includes the time-varying nature, and the inter-patient variability of the glucose-control problem. In addition, the model is well suited for well-known and standard controller synthesis procedures. The outcome is an average linear parameter-varying (LPV) model that captures the dynamics from the insulin delivery input to the glucose concentration output constructed based on the UVA/Padova metabolic simulator. Finally, a system-oriented reinterpretation of the classical ad-hoc 1800 rule is applied to adapt the model's gain. The effectiveness of this approach is quantified both in open- and closed-loop. The first one by computing the root mean square error (RMSE) between the glucose deviation predicted by the proposed model and the UVA/Padova one. The second measure is determined by using the ν-gap as a metric to determine distance, in terms of closed-loop performance, between both models. For comparison purposes, both open- (RMSE) and closed-loop (ν-gap metric) quality indicators are also computed for other control-oriented models previously presented. This model allows the design of LPV controllers in a straightforward way, considering its affine dependence on the time-varying parameter, which can be computed in real-time. Illustrative simulations are included. In addition, the presented modeling strategy was employed in the design of an artificial pancreas (AP) control law that successfully withstood rigorous testing using the UVA/Padova simulator, and that was subsequently deployed in a clinical trial campaign where five adults remained in closed-loop for 36 h. This was the first ever fully closed-loop clinical AP trial in Argentina, and the modeling strategy presented here is considered instrumental in resulting in a very successful clinical outcome.Fil: Colmegna, Patricio Hernán. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sánchez Peña, Ricardo S.. Instituto Tecnológico de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gondhalekar, R.. Harvard University; Estados Unido

Mathematical control of complex systems 2013

Mathematical control of complex systems have already become an ideal research area for control engineers, mathematicians, computer scientists, and biologists to understand, manage, analyze, and interpret functional information/dynamical behaviours from real-world complex dynamical systems, such as communication systems, process control, environmental systems, intelligent manufacturing systems, transportation systems, and structural systems. This special issue aims to bring together the latest/innovative knowledge and advances in mathematics for handling complex systems. Topics include, but are not limited to the following: control systems theory (behavioural systems, networked control systems, delay systems, distributed systems, infinite-dimensional systems, and positive systems); networked control (channel capacity constraints, control over communication networks, distributed filtering and control, information theory and control, and sensor networks); and stochastic systems (nonlinear filtering, nonparametric methods, particle filtering, partial identification, stochastic control, stochastic realization, system identification)

Direct data-driven control of constrained linear parameter-varying systems: A hierarchical approach

In many nonlinear control problems, the plant can be accurately described by a linear model whose operating point depends on some measurable variables, called scheduling signals. When such a linear parameter-varying (LPV) model of the open-loop plant needs to be derived from a set of data, several issues arise in terms of parameterization, estimation, and validation of the model before designing the controller. Moreover, the way modeling errors affect the closed-loop performance is still largely unknown in the LPV context. In this paper, a direct data-driven control method is proposed to design LPV controllers directly from data without deriving a model of the plant. The main idea of the approach is to use a hierarchical control architecture, where the inner controller is designed to match a simple and a-priori specified closed-loop behavior. Then, an outer model predictive controller is synthesized to handle input/output constraints and to enhance the performance of the inner loop. The effectiveness of the approach is illustrated by means of a simulation and an experimental example. Practical implementation issues are also discussed.Comment: Preliminary version of the paper "Direct data-driven control of constrained systems" published in the IEEE Transactions on Control Systems Technolog

Advances in state estimation, diagnosis and control of complex systems

This dissertation intends to provide theoretical and practical contributions on estimation, diagnosis and control of complex systems, especially in the mathematical form of descriptor systems. The research is motivated by real applications, such as water networks and power systems, which require a control system to provide a proper management able to take into account their specific features and operating limits in presence of uncertainties related to their operation and failures from component malfunctions. Such a control system is expected to provide an optimal operation to obtain efficient and reliable performance. State estimation is an essential tool, which can be used not only for fault diagnosis but also for the controller design. To achieve a satisfactory robust performance, set theory is chosen to build a general framework for descriptor systems subject to uncertainties. Under certain assumptions, these uncertainties are propagated and bounded by deterministic sets that can be explicitly characterized at each iteration step. Moreover, set-invariance characterizations for descriptor systems are also of interest to describe the steady performance, which can also be used for active mode detection. For the controller design for complex systems, new developments of economic model predictive control (EMPC) are studied taking into account the case of underlying periodic behaviors. The EMPC controller is designed to be recursively feasible even with sudden changes in the economic cost function and the closed-loop convergence is guaranteed. Besides, a robust technique is plugged into the EMPC controller design to maintain these closed-loop properties in presence of uncertainties. Engineering applications modeled as descriptor systems are presented to illustrate these control strategies. From the real applications, some additional difficulties are solved, such as using a two-layer control strategy to avoid binary variables in real-time optimizations and using nonlinear constraint relaxation to deal with nonlinear algebraic equations in the descriptor model. Furthermore, the fault-tolerant capability is also included in the controller design for descriptor systems by means of the designed virtual actuator and virtual sensor together with an observer-based delayed controller.Esta tesis propone contribuciones de carácter teórico y aplicado para la estimación del estado, el diagnóstico y el control óptimo de sistemas dinámicos complejos en particular, para los sistemas descriptores, incluyendo la capacidad de tolerancia a fallos. La motivación de la tesis proviene de aplicaciones reales, como redes de agua y sistemas de energía, cuya naturaleza crítica requiere necesariamente un sistema de control para una gestión capaz de tener en cuenta sus características específicas y límites operativos en presencia de incertidumbres relacionadas con su funcionamiento, así como fallos de funcionamiento de los componentes. El objetivo es conseguir controladores que mejoren tanto la eficiencia como la fiabilidad de dichos sistemas. La estimación del estado es una herramienta esencial que puede usarse no solo para el diagnóstico de fallos sino también para el diseño del control. Con este fin, se ha decidido utilizar metodologías intervalares, o basadas en conjuntos, para construir un marco general para los sistemas de descriptores sujetos a incertidumbres desconocidas pero acotadas. Estas incertidumbres se propagan y delimitan mediante conjuntos que se pueden caracterizar explícitamente en cada instante. Por otra parte, también se proponen caracterizaciones basadas en conjuntos invariantes para sistemas de descriptores que permiten describir comportamientos estacionarios y resultan útiles para la detección de modos activos. Se estudian también nuevos desarrollos del control predictivo económico basado en modelos (EMPC) para tener en cuenta posibles comportamientos periódicos en la variación de parámetros o en las perturbaciones que afectan a estos sistemas. Además, se demuestra que el control EMPC propuesto garantiza la factibilidad recursiva, incluso frente a cambios repentinos en la función de coste económico y se garantiza la convergencia en lazo cerrado. Por otra parte, se utilizan técnicas de control robusto pata garantizar que las estrategias de control predictivo económico mantengan las prestaciones en lazo cerrado, incluso en presencia de incertidumbre. Los desarrollos de la tesis se ilustran con casos de estudio realistas. Para algunas de aplicaciones reales, se resuelven dificultades adicionales, como el uso de una estrategia de control de dos niveles para evitar incluir variables binarias en la optimización y el uso de la relajación de restricciones no lineales para tratar las ecuaciones algebraicas no lineales en el modelo descriptor en las redes de agua. Finalmente, se incluye también una contribución al diseño de estrategias de control con tolerancia a fallos para sistemas descriptores

Efficient LMI-based quadratic stabilization of interval LPV systems with noisy parameter measures

none2openL. IETTO; Valentina OrsiniIetto, Leopoldo; Orsini, Valentin