10,420 research outputs found
Cell-cell communication enhances the capacity of cell ensembles to sense shallow gradients during morphogenesis
Collective cell responses to exogenous cues depend on cell-cell interactions.
In principle, these can result in enhanced sensitivity to weak and noisy
stimuli. However, this has not yet been shown experimentally, and, little is
known about how multicellular signal processing modulates single cell
sensitivity to extracellular signaling inputs, including those guiding complex
changes in the tissue form and function. Here we explored if cell-cell
communication can enhance the ability of cell ensembles to sense and respond to
weak gradients of chemotactic cues. Using a combination of experiments with
mammary epithelial cells and mathematical modeling, we find that multicellular
sensing enables detection of and response to shallow Epidermal Growth Factor
(EGF) gradients that are undetectable by single cells. However, the advantage
of this type of gradient sensing is limited by the noisiness of the signaling
relay, necessary to integrate spatially distributed ligand concentration
information. We calculate the fundamental sensory limits imposed by this
communication noise and combine them with the experimental data to estimate the
effective size of multicellular sensory groups involved in gradient sensing.
Functional experiments strongly implicated intercellular communication through
gap junctions and calcium release from intracellular stores as mediators of
collective gradient sensing. The resulting integrative analysis provides a
framework for understanding the advantages and limitations of sensory
information processing by relays of chemically coupled cells.Comment: paper + supporting information, total 35 pages, 15 figure
Recent Progress in Image Deblurring
This paper comprehensively reviews the recent development of image
deblurring, including non-blind/blind, spatially invariant/variant deblurring
techniques. Indeed, these techniques share the same objective of inferring a
latent sharp image from one or several corresponding blurry images, while the
blind deblurring techniques are also required to derive an accurate blur
kernel. Considering the critical role of image restoration in modern imaging
systems to provide high-quality images under complex environments such as
motion, undesirable lighting conditions, and imperfect system components, image
deblurring has attracted growing attention in recent years. From the viewpoint
of how to handle the ill-posedness which is a crucial issue in deblurring
tasks, existing methods can be grouped into five categories: Bayesian inference
framework, variational methods, sparse representation-based methods,
homography-based modeling, and region-based methods. In spite of achieving a
certain level of development, image deblurring, especially the blind case, is
limited in its success by complex application conditions which make the blur
kernel hard to obtain and be spatially variant. We provide a holistic
understanding and deep insight into image deblurring in this review. An
analysis of the empirical evidence for representative methods, practical
issues, as well as a discussion of promising future directions are also
presented.Comment: 53 pages, 17 figure
Machine Learning And Image Processing For Noise Removal And Robust Edge Detection In The Presence Of Mixed Noise
The central goal of this dissertation is to design and model a smoothing filter based on the random single and mixed noise distribution that would attenuate the effect of noise while preserving edge details. Only then could robust, integrated and resilient edge detection methods be deployed to overcome the ubiquitous presence of random noise in images. Random noise effects are modeled as those that could emanate from impulse noise, Gaussian noise and speckle noise.
In the first step, evaluation of methods is performed based on an exhaustive review on the different types of denoising methods which focus on impulse noise, Gaussian noise and their related denoising filters. These include spatial filters (linear, non-linear and a combination of them), transform domain filters, neural network-based filters, numerical-based filters, fuzzy based filters, morphological filters, statistical filters, and supervised learning-based filters.
In the second step, switching adaptive median and fixed weighted mean filter (SAMFWMF) which is a combination of linear and non-linear filters, is introduced in order to detect and remove impulse noise. Then, a robust edge detection method is applied which relies on an integrated process including non-maximum suppression, maximum sequence, thresholding and morphological operations. The results are obtained on MRI and natural images.
In the third step, a combination of transform domain-based filter which is a combination of dual tree – complex wavelet transform (DT-CWT) and total variation, is introduced in order to detect and remove Gaussian noise as well as mixed Gaussian and Speckle noise. Then, a robust edge detection is applied in order to track the true edges. The results are obtained on medical ultrasound and natural images.
In the fourth step, a smoothing filter, which is a feed-forward convolutional network (CNN) is introduced to assume a deep architecture, and supported through a specific learning algorithm, l2 loss function minimization, a regularization method, and batch normalization all integrated in order to detect and remove impulse noise as well as mixed impulse and Gaussian noise. Then, a robust edge detection is applied in order to track the true edges. The results are obtained on natural images for both specific and non-specific noise-level
Sparse Modeling for Image and Vision Processing
In recent years, a large amount of multi-disciplinary research has been
conducted on sparse models and their applications. In statistics and machine
learning, the sparsity principle is used to perform model selection---that is,
automatically selecting a simple model among a large collection of them. In
signal processing, sparse coding consists of representing data with linear
combinations of a few dictionary elements. Subsequently, the corresponding
tools have been widely adopted by several scientific communities such as
neuroscience, bioinformatics, or computer vision. The goal of this monograph is
to offer a self-contained view of sparse modeling for visual recognition and
image processing. More specifically, we focus on applications where the
dictionary is learned and adapted to data, yielding a compact representation
that has been successful in various contexts.Comment: 205 pages, to appear in Foundations and Trends in Computer Graphics
and Visio
Robust automatic target tracking based on a Bayesian ego-motion compensation framework for airborne FLIR imagery
Automatic target tracking in airborne FLIR imagery is currently a challenge due to the camera ego-motion. This phenomenon distorts the spatio-temporal correlation of the video sequence, which dramatically reduces the tracking performance. Several works address this problem using ego-motion compensation strategies. They use a deterministic approach to compensate the camera motion assuming a specific model of geometric transformation. However, in real sequences a specific geometric transformation can not accurately describe the camera ego-motion for the whole sequence, and as consequence of this, the performance of the tracking stage can significantly decrease, even completely fail. The optimum transformation for each pair of consecutive frames depends on the relative depth of the elements that compose the scene, and their degree of texturization. In this work, a novel Particle Filter framework is proposed to efficiently manage several hypothesis of geometric transformations: Euclidean, affine, and projective. Each type of transformation is used to compute candidate locations of the object in the current frame. Then, each candidate is evaluated by the measurement model of the Particle Filter using the appearance information. This approach is able to adapt to different camera ego-motion conditions, and thus to satisfactorily perform the tracking. The proposed strategy has been tested on the AMCOM FLIR dataset, showing a high efficiency in the tracking of different types of targets in real working conditions
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