Exhaustive search for epistatic effects on the human methylome

Studies assessing the existence and magnitude of epistatic effects on complex human traits provide inconclusive results. The study of such effects is complicated by considerable increase in computational burden, model complexity, and model uncertainty, which in concert decrease model stability. An additional source introducing significant uncertainty with regard to the detection of robust epistasis is the biological distance between the genetic variation and the trait under study. Here we studied CpG methylation, a genetically complex molecular trait that is particularly close to genomic variation, and performed an exhaustive search for two-locus epistatic effects on the CpG-methylation signal in two cohorts of healthy young subjects. We detected robust epistatic effects for a small number of CpGs (N = 404). Our results indicate that epistatic effects explain only a minor part of variation in DNA-CpG methylation. Interestingly, these CpGs were more likely to be associated with gene-expression of nearby genes, as also shown by their overrepresentation in DNase I hypersensitivity sites and underrepresentation in CpG islands. Finally, gene ontology analysis showed a significant enrichment of these CpGs in pathways related to HPV-infection and cancer

On the Equivalence of f-Divergence Balls and Density Bands in Robust Detection

The paper deals with minimax optimal statistical tests for two composite hypotheses, where each hypothesis is defined by a non-parametric uncertainty set of feasible distributions. It is shown that for every pair of uncertainty sets of the f-divergence ball type, a pair of uncertainty sets of the density band type can be constructed, which is equivalent in the sense that it admits the same pair of least favorable distributions. This result implies that robust tests under $f$-divergence ball uncertainty, which are typically only minimax optimal for the single sample case, are also fixed sample size minimax optimal with respect to the equivalent density band uncertainty sets.Comment: 5 pages, 1 figure, accepted for publication in the Proceedings of the IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP) 201

Sensing Throughput Tradeoff for Cognitive Radio Networks with Noise Variance Uncertainty

This paper proposes novel spectrum sensing algorithm, and examines the sensing throughput tradeoff for cognitive radio (CR) networks under noise variance uncertainty. It is assumed that there are one white sub-band, and one target sub-band which is either white or non-white. Under this assumption, first we propose a novel generalized energy detector (GED) for examining the target sub-band by exploiting the noise information of the white sub-band, then, we study the tradeoff between the sensing time and achievable throughput of the CR network. To study this tradeoff, we consider the sensing time optimization for maximizing the throughput of the CR network while appropriately protecting the primary network. The sensing time is optimized by utilizing the derived detection and false alarm probabilities of the GED. The proposed GED does not suffer from signal to noise ratio (SNR) wall (i.e., robust against noise variance uncertainty) and outperforms the existing signal detectors. Moreover, the relationship between the proposed GED and conventional energy detector (CED) is quantified analytically. We show that the optimal sensing times with perfect and imperfect noise variances are not the same. In particular, when the frame duration is 2s, and SNR is -20dB, and each of the bandwidths of the white and target sub-bands is 6MHz, the optimal sensing times are 28.5ms and 50.6ms with perfect and imperfect noise variances, respectively.Comment: Accepted in CROWNCOM, June 2014, Oulu, Finlan

Design and assessment of a multiple sensor fault tolerant robust control system

This paper presents an enhanced robust control design structure to realise fault tolerance towards sensor faults suitable for multi-input-multi-output (MIMO) systems implementation. The proposed design permits fault detection and controller elements to be designed with considerations to stability and robustness towards uncertainties besides multiple faults environment on a common mathematical platform. This framework can also cater to systems requiring fast responses. A design example is illustrated with a fast, multivariable and unstable system, that is, the double inverted pendulum system. Results indicate the potential of this design framework to handle fast systems with multiple sensor faults