A Robust Interpretable Deep Learning Classifier for Heart Anomaly Detection Without Segmentation

Traditionally, abnormal heart sound classification is framed as a three-stage process. The first stage involves segmenting the phonocardiogram to detect fundamental heart sounds; after which features are extracted and classification is performed. Some researchers in the field argue the segmentation step is an unwanted computational burden, whereas others embrace it as a prior step to feature extraction. When comparing accuracies achieved by studies that have segmented heart sounds before analysis with those who have overlooked that step, the question of whether to segment heart sounds before feature extraction is still open. In this study, we explicitly examine the importance of heart sound segmentation as a prior step for heart sound classification, and then seek to apply the obtained insights to propose a robust classifier for abnormal heart sound detection. Furthermore, recognizing the pressing need for explainable Artificial Intelligence (AI) models in the medical domain, we also unveil hidden representations learned by the classifier using model interpretation techniques. Experimental results demonstrate that the segmentation plays an essential role in abnormal heart sound classification. Our new classifier is also shown to be robust, stable and most importantly, explainable, with an accuracy of almost 100% on the widely used PhysioNet dataset

In silico transitions to multicellularity

The emergence of multicellularity and developmental programs are among the major problems of evolutionary biology. Traditionally, research in this area has been based on the combination of data analysis and experimental work on one hand and theoretical approximations on the other. A third possibility is provided by computer simulation models, which allow to both simulate reality and explore alternative possibilities. These in silico models offer a powerful window to the possible and the actual by means of modeling how virtual cells and groups of cells can evolve complex interactions beyond a set of isolated entities. Here we present several examples of such models, each one illustrating the potential for artificial modeling of the transition to multicellularity.Comment: 21 pages, 10 figures. Book chapter of Evolutionary transitions to multicellular life (Springer

Explaining Classifiers using Adversarial Perturbations on the Perceptual Ball

We present a simple regularization of adversarial perturbations based upon the perceptual loss. While the resulting perturbations remain imperceptible to the human eye, they differ from existing adversarial perturbations in that they are semi-sparse alterations that highlight objects and regions of interest while leaving the background unaltered. As a semantically meaningful adverse perturbations, it forms a bridge between counterfactual explanations and adversarial perturbations in the space of images. We evaluate our approach on several standard explainability benchmarks, namely, weak localization, insertion deletion, and the pointing game demonstrating that perceptually regularized counterfactuals are an effective explanation for image-based classifiers.Comment: CVPR 202

Learning the Preferences of Ignorant, Inconsistent Agents

An important use of machine learning is to learn what people value. What posts or photos should a user be shown? Which jobs or activities would a person find rewarding? In each case, observations of people's past choices can inform our inferences about their likes and preferences. If we assume that choices are approximately optimal according to some utility function, we can treat preference inference as Bayesian inverse planning. That is, given a prior on utility functions and some observed choices, we invert an optimal decision-making process to infer a posterior distribution on utility functions. However, people often deviate from approximate optimality. They have false beliefs, their planning is sub-optimal, and their choices may be temporally inconsistent due to hyperbolic discounting and other biases. We demonstrate how to incorporate these deviations into algorithms for preference inference by constructing generative models of planning for agents who are subject to false beliefs and time inconsistency. We explore the inferences these models make about preferences, beliefs, and biases. We present a behavioral experiment in which human subjects perform preference inference given the same observations of choices as our model. Results show that human subjects (like our model) explain choices in terms of systematic deviations from optimal behavior and suggest that they take such deviations into account when inferring preferences.Comment: AAAI 201

Reactive control and reasoning assistance for scientific laboratory instruments

Scientific laboratory instruments that are involved in chemical or physical sample identification frequently require substantial human preparation, attention, and interactive control during their operation. Successful real-time analysis of incoming data that supports such interactive control requires: (1) a clear recognition of variance of the data from expected results; and (2) rapid diagnosis of possible alternative hypotheses which might explain the variance. Such analysis then aids in decisions about modifying the experiment protocol, as well as being a goal itself. This paper reports on a collaborative project at the NASA Ames Research Center between artificial intelligence researchers and planetary microbial ecologists. Our team is currently engaged in developing software that autonomously controls science laboratory instruments and that provides data analysis of the real-time data in support of dynamic refinement of the experiment control. the first two instruments to which this technology has been applied are a differential thermal analyzer (DTA) and a gas chromatograph (GC). coupled together, they form a new geochemicstry and microbial analysis tool that is capable of rapid identification of the organiz and mineralogical constituents in soils. The thermal decomposition of the minerals and organics, and the attendance release of evolved gases, provides data about the structural and molecular chemistry of the soil samples