Robust optimization of cardiovascular stents: A comparison of methods

This is the post-print version of the Article. The official published version can be accssed from the links below. Copyright @ 2004 Taylor & FrancisModern engineering design contains both creative and analytic components. This paper discusses the design process and illustrates links between design optimization and conceptual design through the re-design of a cardiovascular stent. A comparison is presented of two methods for design improvement: genetic algorithms (GA) and model-based robust engineering design (RED). Computational fluid dynamics (CFD) models are used to generate measurements of the quality of competing designs based on the concept of dissipated power. Alternative performance measures are also discussed. Environmental noise is introduced into the analysis and consideration is given to the treatment of discrete and continuous design parameters. Improved designs are identified using both methods and verified with further CFD analyses, and the benefits of each method are discussed

Searching for improvement

Engineering design can be thought of as a search for the best solutions to engineering problems. To perform an effective search, one must distinguish between competing designs and establish a measure of design quality, or fitness. To compare different designs, their features must be adequately described in a well-defined framework, which can mean separating the creative and analytical parts of the design process. By this we mean that a distinction is drawn between coming up with novel design concepts, or architectures, and the process of detailing or refining existing design architecture. In the case of a given design architecture, one can consider the set of all possible designs that could be created by varying its features. If it were possible to measure the fitness of all designs in this set, then one could identify a fitness landscape and search for the best possible solution for this design architecture. In this Chapter, the significance of the interactions between design features in defining the metaphorical fitness landscape is described. This highlights that the efficiency of a search algorithm is inextricably linked to the problem structure (and hence the landscape). Two approaches, namely, Genetic Algorithms (GA) and Robust Engineering Design (RED) are considered in some detail with reference to a case study on improving the design of cardiovascular stents

Algorithms for automated DNA assembly

Generating a defined set of genetic constructs within a large combinatorial space provides a powerful method for engineering novel biological functions. However, the process of assembling more than a few specific DNA sequences can be costly, time consuming and error prone. Even if a correct theoretical construction scheme is developed manually, it is likely to be suboptimal by any number of cost metrics. Modular, robust and formal approaches are needed for exploring these vast design spaces. By automating the design of DNA fabrication schemes using computational algorithms, we can eliminate human error while reducing redundant operations, thus minimizing the time and cost required for conducting biological engineering experiments. Here, we provide algorithms that optimize the simultaneous assembly of a collection of related DNA sequences. We compare our algorithms to an exhaustive search on a small synthetic dataset and our results show that our algorithms can quickly find an optimal solution. Comparison with random search approaches on two real-world datasets show that our algorithms can also quickly find lower-cost solutions for large datasets

Performance-based control system design automation via evolutionary computing

This paper develops an evolutionary algorithm (EA) based methodology for computer-aided control system design (CACSD) automation in both the time and frequency domains under performance satisfactions. The approach is automated by efficient evolution from plant step response data, bypassing the system identification or linearization stage as required by conventional designs. Intelligently guided by the evolutionary optimization, control engineers are able to obtain a near-optimal ‘‘off-thecomputer’’ controller by feeding the developed CACSD system with plant I/O data and customer specifications without the need of a differentiable performance index. A speedup of near-linear pipelineability is also observed for the EA parallelism implemented on a network of transputers of Parsytec SuperCluster. Validation results against linear and nonlinear physical plants are convincing, with good closed-loop performance and robustness in the presence of practical constraints and perturbations

On-line multiobjective automatic control system generation by evolutionary algorithms

Evolutionary algorithms are applied to the on- line generation of servo-motor control systems. In this paper, the evolving population of controllers is evaluated at run-time via hardware in the loop, rather than on a simulated model. Disturbances are also introduced at run-time in order to pro- duce robust performance. Multiobjective optimisation of both PI and Fuzzy Logic controllers is considered. Finally an on-line implementation of Genetic Programming is presented based around the Simulink standard blockset. The on-line designed controllers are shown to be robust to both system noise and ex- ternal disturbances while still demonstrating excellent steady- state and dvnamic characteristics

Optimisation of the weighting functions of an H_∞ controller using genetic algorithms and structured genetic algorithms

In this paper the optimisation of the weighting functions for an H<sub>∞</sub> controller using genetic algorithms and structured genetic algorithms is considered. The choice of the weighting functions is one of the key steps in the design of an H<sub>∞</sub> controller. The performance of the controller depends on these weighting functions since poorly chosen weighting functions will provide a poor controller. One approach that can solve this problem is the use of evolutionary techniques to tune the weighting parameters. The paper presents the improved performance of structured genetic algorithms over conventional genetic algorithms and how this technique can assist with the identification of appropriate weighting functions' orders

Multi-objective design optimisation of a 3D-rail stamping process using a robust multi-objective optimisation platform (RMOP)

The paper investigates the multi-objective design optimisation of a stamping process to control the final shape and the final quality using advanced high strength steels. The design problem of the stamping process is formulated to minimise the difference between the desired shape and the final geometry obtained by numerical simulation accounting elastic springback. In addition, the final product quality is maximised by improving safety zones without wrinkling, thinning, or failure. Numerical results show that the proposed methodology improves the final product quality while reduces its springback.Peer ReviewedPostprint (published version