A framework for modeling and analysis of dynamical properties of spiking neurons

A hybrid systems framework for modeling and analysis of robust stability of spiking neurons is proposed. The framework is developed for a population of n interconnected neurons. Several well-known neuron models are studied within the framework, including both excitatory and inhibitory simplified Hodgkin-Huxley, Hopf, and SNIPER models. For each model, we characterize the sets that the solutions to each system converge to. Using Lyapunov stability tools for hybrid systems, the stability properties for each case are established. An external stimuli is introduced to the simplified Hodgkin-Huxley model to achieve a global asymptotic stability property. Due to the regularity properties of the data of the hybrid models considered, the asserted stability properties are robust to small perturbations. Simulations provide insight on the results and the capabilities of the proposed framework. © 2014 American Automatic Control Council

Coordination of multi-agent systems: stability via nonlinear Perron-Frobenius theory and consensus for desynchronization and dynamic estimation.

This thesis addresses a variety of problems that arise in the study of complex networks composed by multiple interacting agents, usually called multi-agent systems (MASs). Each agent is modeled as a dynamical system whose dynamics is fully described by a state-space representation. In the first part the focus is on the application to MASs of recent results that deal with the extensions of Perron-Frobenius theory to nonlinear maps. In the shift from the linear to the nonlinear framework, Perron-Frobenius theory considers maps being order-preserving instead of matrices being nonnegative. The main contribution is threefold. First of all, a convergence analysis of the iterative behavior of two novel classes of order-preserving nonlinear maps is carried out, thus establishing sufficient conditions which guarantee convergence toward a fixed point of the map: nonnegative row-stochastic matrices turns out to be a special case. Secondly, these results are applied to MASs, both in discrete and continuous-time: local properties of the agents' dynamics have been identified so that the global interconnected system falls into one of the above mentioned classes, thus guaranteeing its global stability. Lastly, a sufficient condition on the connectivity of the communication network is provided to restrict the set of equilibrium points of the system to the consensus points, thus ensuring the agents to achieve consensus. These results do not rely on standard tools (e.g., Lyapunov theory) and thus they constitute a novel approach to the analysis and control of multi-agent dynamical systems. In the second part the focus is on the design of dynamic estimation algorithms in large networks which enable to solve specific problems. The first problem consists in breaking synchronization in networks of diffusively coupled harmonic oscillators. The design of a local state feedback that achieves desynchronization in connected networks with arbitrary undirected interactions is provided. The proposed control law is obtained via a novel protocol for the distributed estimation of the Fiedler vector of the Laplacian matrix. The second problem consists in the estimation of the number of active agents in networks wherein agents are allowed to join or leave. The adopted strategy consists in the distributed and dynamic estimation of the maximum among numbers locally generated by the active agents and the subsequent inference of the number of the agents that took part in the experiment. Two protocols are proposed and characterized to solve the consensus problem on the time-varying max value. The third problem consists in the average state estimation of a large network of agents where only a few agents' states are accessible to a centralized observer. The proposed strategy projects the dynamics of the original system into a lower dimensional state space, which is useful when dealing with large-scale systems. Necessary and sufficient conditions for the existence of a linear and a sliding mode observers are derived, along with a characterization of their design and convergence properties

Sensitivity analysis of oscillator models in the space of phase-response curves: Oscillators as open systems

Oscillator models are central to the study of system properties such as entrainment or synchronization. Due to their nonlinear nature, few system-theoretic tools exist to analyze those models. The paper develops a sensitivity analysis for phase-response curves, a fundamental one-dimensional phase reduction of oscillator models. The proposed theoretical and numerical analysis tools are illustrated on several system-theoretic questions and models arising in the biology of cellular rhythms

Coordination and Privacy Preservation in Multi-Agent Systems

This dissertation considers two key problems in multi-agent systems: coordination (including both synchronization and desynchronization) and privacy preservation. For coordination in multi-agent systems, we focus on synchronization/desynchronization of distributed pulse-coupled oscillator (PCO) networks and their applications in collective motion coordination. Pulse-coupled oscillators were originally proposed to model synchronization in biological systems such as flashing fireflies and firing neurons. In recent years, with proven scalability, simplicity, accuracy, and robustness, the PCO based synchronization strategy has become a powerful clock synchronization primitive for wireless sensor networks. Driven by these increased applications in biological networks and wireless sensor networks, synchronization of pulse-coupled oscillators has gained increased popularity. However, most existing results address the local synchronization of PCOs with initial phases constrained in a half cycle, and results on global synchronization from any initial condition are very sparse. In our work, we address global PCO synchronization from an arbitrary phase distribution under chain or directed tree graphs. More importantly, different from existing global synchronization studies on decentralized PCO networks, our work allows heterogeneous coupling functions and perturbations on PCOs\u27 natural frequencies, and our results hold under any coupling strength between zero and one, which is crucial because a large coupling strength has been shown to be detrimental to the robustness of PCO synchronization to disturbances. Compared with synchronization, desynchronization of PCOs is less explored. Desynchronization spreads the phase variables of all PCOs uniformly apart (with equal difference between neighboring phases). It has also been found in many biological phenomena, such as neuron spiking and fish signaling. Recently, phase desynchronization has been employed to achieve round-robin scheduling, which is crucial in applications as diverse as media access control of communication networks, realization of analog-to-digital converters, and scheduling of traffic flows in intersections. In our work, we systematically characterize pulse-coupled oscillators based decentralized phase desynchronization and propose an interaction function that is more general than existing results. Numerical simulations show that the proposed pulse based interaction function also has better robustness to pulse losses, time delays, and frequency errors than existing results. Collective motion coordination is fundamental in systems as diverse as mobile sensor networks, swarm robotics, autonomous vehicles, and animal groups. Inspired by the close relationship between phase synchronization/desynchronization of PCOs and the heading dynamics of connected vehicles/robots, we propose a pulse-based integrated communication and control approach for collective motion coordination. Our approach only employs simple and identical pulses, which significantly reduces processing latency and communication delay compared with conventional packet based communications. Not only can heading control be achieved in the proposed approach to coordinate the headings (orientations) of motions in a network, but also spacing control for circular motion is achievable to design the spacing between neighboring nodes (e.g., vehicles or robots). The second part of this dissertation is privacy preservation in multi-agent systems. More specifically, we focus on privacy-preserving average consensus as it is key for multi-agent systems, with applications ranging from time synchronization, information fusion, load balancing, to decentralized control. Existing average consensus algorithms require individual nodes (agents) to exchange explicit state values with their neighbors, which leads to the undesirable disclosure of sensitive information in the state. In our work, we propose a novel average consensus algorithm for time-varying directed graphs which can protect the privacy of participating nodes\u27 initial states. Leveraging algorithm-level obfuscation, the algorithm does not need the assistance of any trusted third party or data aggregator. By leveraging the inherent robustness of consensus dynamics against random variations in interaction, our proposed algorithm can guarantee privacy of participating nodes without compromising the accuracy of consensus. The algorithm is distinctly different from differential-privacy based average consensus approaches which enable privacy through compromising accuracy in obtained consensus value. The approach is able to protect the privacy of participating nodes even in the presence of multiple honest-but-curious nodes which can collude with each other

Phase Desynchronization in Pulse-Coupled Oscillator Networks: A New Algorithm and Approach

In this thesis, we present a novel approach for achieving phase desynchronization in a pulse-coupled oscillator network. Ensuring phase desynchronization is a difficult problem, and existing results are constrained to a completely interconnected network and a fixed number of oscillators. Our approach is more robust than previous approaches, removing the constraint of a fixed number of oscillators. The removal of this constraint is significant because it allows the network to receive and drop nodes freely without any change to the phase update strategy. Also, to our knowledge, our approach is the first to prove the convergence to the desynchronized state for a topology that is more general than the all-to-all topology. More specifically, our approach is applicable to any circulant and symmetric network topology, including the circulant symmetric ring topology. Rigorous mathematical proofs are provided to support the result that any circulant symmetric network with ordered phases under our proposed algorithm will converge to uniform phase desynchronization. Simulation results are presented to demonstrate the algorithm\u27s performance, as well as experimental results on a physical system to further illustrate applications of pulse-coupled oscillator networks

Synchronization in complex networks

Synchronization processes in populations of locally interacting elements are in the focus of intense research in physical, biological, chemical, technological and social systems. The many efforts devoted to understand synchronization phenomena in natural systems take now advantage of the recent theory of complex networks. In this review, we report the advances in the comprehension of synchronization phenomena when oscillating elements are constrained to interact in a complex network topology. We also overview the new emergent features coming out from the interplay between the structure and the function of the underlying pattern of connections. Extensive numerical work as well as analytical approaches to the problem are presented. Finally, we review several applications of synchronization in complex networks to different disciplines: biological systems and neuroscience, engineering and computer science, and economy and social sciences.Comment: Final version published in Physics Reports. More information available at http://synchronets.googlepages.com

Robust Engineering of Dynamic Structures in Complex Networks

Populations of nearly identical dynamical systems are ubiquitous in natural and engineered systems, in which each unit plays a crucial role in determining the functioning of the ensemble. Robust and optimal control of such large collections of dynamical units remains a grand challenge, especially, when these units interact and form a complex network. Motivated by compelling practical problems in power systems, neural engineering and quantum control, where individual units often have to work in tandem to achieve a desired dynamic behavior, e.g., maintaining synchronization of generators in a power grid or conveying information in a neuronal network; in this dissertation, we focus on developing novel analytical tools and optimal control policies for large-scale ensembles and networks. To this end, we first formulate and solve an optimal tracking control problem for bilinear systems. We developed an iterative algorithm that synthesizes the optimal control input by solving a sequence of state-dependent differential equations that characterize the optimal solution. This iterative scheme is then extended to treat isolated population or networked systems. We demonstrate the robustness and versatility of the iterative control algorithm through diverse applications from different fields, involving nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI), electrochemistry, neuroscience, and neural engineering. For example, we design synchronization controls for optimal manipulation of spatiotemporal spike patterns in neuron ensembles. Such a task plays an important role in neural systems. Furthermore, we show that the formation of such spatiotemporal patterns is restricted when the network of neurons is only partially controllable. In neural circuitry, for instance, loss of controllability could imply loss of neural functions. In addition, we employ the phase reduction theory to leverage the development of novel control paradigms for cyclic deferrable loads, e.g., air conditioners, that are used to support grid stability through demand response (DR) programs. More importantly, we introduce novel theoretical tools for evaluating DR capacity and bandwidth. We also study pinning control of complex networks, where we establish a control-theoretic approach to identifying the most influential nodes in both undirected and directed complex networks. Such pinning strategies have extensive practical implications, e.g., identifying the most influential spreaders in epidemic and social networks, and lead to the discovery of degenerate networks, where the most influential node relocates depending on the coupling strength. This phenomenon had not been discovered until our recent study