Prostate

RMS, rhabdomyosar-Abstract Background: The surgical management of paediatric bladder/prostate rhabdomyosarcoma (B/P RMS) continues to develop, with the goal of maximising organ preservation while achieving successful cancer control. The timing of radio-therapy and surgical excision to improve event-free survival (EFS) and overall sur-vival (OS) remains controversial. Methods: Previous reports in English on B/P RMS over the past 15 years were identified and reviewed, focusing on studies comparing the effects of radiotherapy and surgery for local control, the effect of local control on OS, and improved means of diagnosing viable tumour after chemotherapy. Results: The concept of lowering the ‘cost of cure ’ drives current protocols. Blad-otherapy, with a f urine, and add-tudies suggesting therapy did not determinants o

Mastering Endo-Laparoscopic and Thoracoscopic Surgery

This is an open access book. The book focuses mainly on the surgical technique, OR setup, equipments and devices necessary in minimally invasive surgery (MIS). It serves as a compendium of endolaparoscopic surgical procedures. It is an official publication of the Endoscopic and Laparoscopic Surgeons of Asia (ELSA). The book includes various sections covering basic skills set, devices, equipments, OR setup, procedures by area. Each chapter cover introduction, indications and contraindications, pre-operative patient’s assessment and preparation, OT setup (instrumentation required, patient’s position, etc.), step by step description of surgical procedures, management of complications, post-operative care. It includes original illustrations for better understanding and visualization of specific procedures. The book serves as a practical guide for surgical residents, surgical trainees, surgical fellows, junior surgeons, surgical consultants and anyone interested in MIS. It covers most of the basic and advanced laparoscopic and thoracoscopic surgery procedures meeting the curriculum and examination requirements of the residents

Mastering Endo-Laparoscopic and Thoracoscopic Surgery

This is an open access book. The book focuses mainly on the surgical technique, OR setup, equipments and devices necessary in minimally invasive surgery (MIS). It serves as a compendium of endolaparoscopic surgical procedures. It is an official publication of the Endoscopic and Laparoscopic Surgeons of Asia (ELSA). The book includes various sections covering basic skills set, devices, equipments, OR setup, procedures by area. Each chapter cover introduction, indications and contraindications, pre-operative patient’s assessment and preparation, OT setup (instrumentation required, patient’s position, etc.), step by step description of surgical procedures, management of complications, post-operative care. It includes original illustrations for better understanding and visualization of specific procedures. The book serves as a practical guide for surgical residents, surgical trainees, surgical fellows, junior surgeons, surgical consultants and anyone interested in MIS. It covers most of the basic and advanced laparoscopic and thoracoscopic surgery procedures meeting the curriculum and examination requirements of the residents

Updated Topics in Minimally Invasive Abdominal Surgery

Updated topics in minimally invasive abdominal surgery provides surgeons interested in minimally invasive abdominal surgery with the most recent techniques and discussions in laparoscopic surgery. This book includes different topics covering a big variety of medical conditions with up-to-date information. It discusses many controversies in a clear and user-friendly manner. This book is made for young junior surgeons in training and also senior surgeons who need to know the most recent work in the field of laparoscopy. To make the material easily digestive, we provided the book with many figures and illustrations for different procedures and technical pearls

Novel Artificial Urinary Sphincter for Stress Urinary Incontinence Treatment

University of Minnesota M.S.E.E. thesis. September 2017. Major: Electrical Engineering. Advisor: Gerald Timm. 1 computer file (PDF); xiv, 129 pages.The American Medical System’s AMS 800TM has been the gold standard for over 40 years with over 150,000 patients treated for Urinary Incontinence and is the leading treatment for male stress urinary incontinence (SUI) following prostate surgery. Type III SUI, or intrinsic sphincter deficiency, is the inability of the urethra to maintain closure pressure sufficient to keep the patient clinically dry at rest and during periods of heightened activity (~120 cmH2O; coughs, sneezes, posture changes, and exercises). The current AMS 800TM is not personalized to a patient’s needs and compromises with an in between pressure- as high (61-70 cmH2O) as it can be without exceeding safety threshold levels. As such many men still leak when they are active. The market is hungry for a device that can adapt to the patient’s level of activity, reducing pressure most of the day to protect the urethra and then briefly increasing the pressure when he is more active. We are developing a novel implantable pump (henceforth called “add-on device”) which will be an add-on to the AMS 800TM and it includes a solenoid coil-cum-plunger and a fluid reservoir within the pump body. The add-on device will be small, light-weight and battery powered, and maintain compatibility with the AMS 800TM device. The device idea is in its proof-of-concept stage. This add-on device can be a possible solution to reducing the risks including urethral atrophy (leading to return of incontinence) and erosion (leading to infection of the implant) resulting from the constant pressure

The role of steroid hormone receptors in prostate cancer. A study of estrogen- and progesterone receptors in adenocarcinoma of the prostate

Steroid hormones and their receptors are vital for numerous physiological processes in the human body, but also related to the development of several malignancies. One such receptor strongly associated with prostate cancer, is the androgen receptor. Other steroid hormone receptors are also implicated in prostate cancer, their role, however, remains to be defined. Using immunohistochemistry and tissue microarray technology, we sought to examine the tissue distribution of a selection of steroid hormone related biomarkers in radical prostatectomy specimens from our cohort of 535 prostate cancer patients. Further, we investigated the association with marker expression and patient outcome. The included biomarkers were the progesterone receptor and its isoforms, A and B, the estrogen receptor- alpha and beta and aromatase, the enzyme converting androgens to estrogen. In prostate cancer, a great challenge remains in separating patients with indolent disease from those with an aggressive cancer. This has motivated the search for prognostic biomarkers that can aid patients risk stratification and guide treatment decisions. In our research, a significant and independent prognostic value was observed for all investigated biomarkers. Based on these observations, we propose a role of these steroid hormone related receptors and enzyme in the pathogenesis of prostate cancer. With further validation, they could have potential as prognostic biomarkers, and possibly a value in future prostate cancer treatment