SHARE roadmap 1:Towards a debate

10 pagesInternational audienceWe present the ‘HealthGrid' initiative and review work carried out in various European projects. Since the European Commission's Information Society Technologies programme funded the first grid-based health and medical projects, the HealthGrid movement has flourished in Europe. Many projects have now been completed and ‘Healthgrid' consulted a number of experts to compile and publish a ‘White Paper' which establishes the foundations, potential scope and prospects of an approach to health informatics based on a grid infrastructure. The White Paper demonstrates the ways in which the healthgrid approach supports many modern trends in medicine and healthcare, such as evidence-based practice, integration across levels, from molecules and cells, through tissues and organs to the whole person and community, and the promise of individualized health care. A second generation of projects have now been funded, and the EC has commissioned a study to define a research roadmap for a ‘healthgrid for Europe', seen as the preferred infrastructure for medical and health care projects in the European Research Area

Proposing a roadmap for HealthGrids

Présentation commune des éditeur

Innovative in silico approaches to address avian flu using grid technology

The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper presents how we are currently exploring how to integrate the existing data sources towards a global surveillance network for molecular epidemiology.Comment: 7 pages, submitted to Infectious Disorders - Drug Target

Data integration in eHealth: a domain/disease specific roadmap

The paper documents a series of data integration workshops held in 2006 at the UK National e-Science Centre, summarizing a range of the problem/solution scenarios in multi-site and multi-scale data integration with six HealthGrid projects using schizophrenia as a domain-specific test case. It outlines emerging strategies, recommendations and objectives for collaboration on shared ontology-building and harmonization of data for multi-site trials in this domain

Care pathway records with ontologies: Potential uses in medical research and health care

This is one of a series of papers arising in part out of the SHARE (Supporting and structuring Healthgrid Activities and Research in Europe) project; in previous work, we have examined the use of integrated care pathways (ICPs), a fine-grained form of medical guideline including the explicit recording of any deviation, or ‘variance’, for research purposes. In particular, we explored how feeding the results of the analysis of variance into the development of a pathway might be an effective way of capturing ‘evidence from practice’.Building on this concept, in our principal case study we propose an information system for extracting data from ICPs using ontologies and a method for inferring ICPs from other patient records, combining these with data collected for retrospective and prospective studies in preimplantation genetic diagnosis (PGD) and screening (PGS) for assisted reproduction. We also look at the problem of selecting alternatives when drug interactions occur when multiple pathways are used in parallel