Sparse Representation-Based Framework for Preprocessing Brain MRI

This thesis addresses the use of sparse representations, specifically Dictionary Learning and Sparse Coding, for pre-processing brain MRI, so that the processed image retains the fine details of the original image, to improve the segmentation of brain structures, to assess whether there is any relationship between alterations in brain structures and the behavior of young offenders. Denoising an MRI while keeping fine details is a difficult task; however, the proposed method, based on sparse representations, NLM, and SVD can filter noise while prevents blurring, artifacts, and residual noise. Segmenting an MRI is a non-trivial task; because normally the limits between regions in these images may be neither clear nor well defined, due to the problems which affect MRI. However, this method, from both the label matrix of the segmented MRI and the original image, yields a new improved label matrix in which improves the limits among regions.DoctoradoDoctor en Ingeniería de Sistemas y Computació

Mixed noise removal using adaptive median based non-local rank minimization

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Advanced Computational Methods for Oncological Image Analysis

[Cancer is the second most common cause of death worldwide and encompasses highly variable clinical and biological scenarios. Some of the current clinical challenges are (i) early diagnosis of the disease and (ii) precision medicine, which allows for treatments targeted to specific clinical cases. The ultimate goal is to optimize the clinical workflow by combining accurate diagnosis with the most suitable therapies. Toward this, large-scale machine learning research can define associations among clinical, imaging, and multi-omics studies, making it possible to provide reliable diagnostic and prognostic biomarkers for precision oncology. Such reliable computer-assisted methods (i.e., artificial intelligence) together with clinicians’ unique knowledge can be used to properly handle typical issues in evaluation/quantification procedures (i.e., operator dependence and time-consuming tasks). These technical advances can significantly improve result repeatability in disease diagnosis and guide toward appropriate cancer care. Indeed, the need to apply machine learning and computational intelligence techniques has steadily increased to effectively perform image processing operations—such as segmentation, co-registration, classification, and dimensionality reduction—and multi-omics data integration.