8 research outputs found

    A New Evolutionary Algorithm For Mining Noisy, Epistatic, Geospatial Survey Data Associated With Chagas Disease

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    The scientific community is just beginning to understand some of the profound affects that feature interactions and heterogeneity have on natural systems. Despite the belief that these nonlinear and heterogeneous interactions exist across numerous real-world systems (e.g., from the development of personalized drug therapies to market predictions of consumer behaviors), the tools for analysis have not kept pace. This research was motivated by the desire to mine data from large socioeconomic surveys aimed at identifying the drivers of household infestation by a Triatomine insect that transmits the life-threatening Chagas disease. To decrease the risk of transmission, our colleagues at the laboratory of applied entomology and parasitology have implemented mitigation strategies (known as Ecohealth interventions); however, limited resources necessitate the search for better risk models. Mining these complex Chagas survey data for potential predictive features is challenging due to imbalanced class outcomes, missing data, heterogeneity, and the non-independence of some features. We develop an evolutionary algorithm (EA) to identify feature interactions in Big Datasets with desired categorical outcomes (e.g., disease or infestation). The method is non-parametric and uses the hypergeometric PMF as a fitness function to tackle challenges associated with using p-values in Big Data (e.g., p-values decrease inversely with the size of the dataset). To demonstrate the EA effectiveness, we first test the algorithm on three benchmark datasets. These include two classic Boolean classifier problems: (1) the majority-on problem and (2) the multiplexer problem, as well as (3) a simulated single nucleotide polymorphism (SNP) disease dataset. Next, we apply the EA to real-world Chagas Disease survey data and successfully archived numerous high-order feature interactions associated with infestation that would not have been discovered using traditional statistics. These feature interactions are also explored using network analysis. The spatial autocorrelation of the genetic data (SNPs of Triatoma dimidiata) was captured using geostatistics. Specifically, a modified semivariogram analysis was performed to characterize the SNP data and help elucidate the movement of the vector within two villages. For both villages, the SNP information showed strong spatial autocorrelation albeit with different geostatistical characteristics (sills, ranges, and nuggets). These metrics were leveraged to create risk maps that suggest the more forested village had a sylvatic source of infestation, while the other village had a domestic/peridomestic source. This initial exploration into using Big Data to analyze disease risk shows that novel and modified existing statistical tools can improve the assessment of risk on a fine-scale

    Conference on Intelligent Robotics in Field, Factory, Service, and Space (CIRFFSS 1994), volume 1

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    The AIAA/NASA Conference on Intelligent Robotics in Field, Factory, Service, and Space (CIRFFSS '94) was originally proposed because of the strong belief that America's problems of global economic competitiveness and job creation and preservation can partly be solved by the use of intelligent robotics, which are also required for human space exploration missions. Individual sessions addressed nuclear industry, agile manufacturing, security/building monitoring, on-orbit applications, vision and sensing technologies, situated control and low-level control, robotic systems architecture, environmental restoration and waste management, robotic remanufacturing, and healthcare applications

    Reports to the President

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    A compilation of annual reports for the 1999-2000 academic year, including a report from the President of the Massachusetts Institute of Technology, as well as reports from the academic and administrative units of the Institute. The reports outline the year's goals, accomplishments, honors and awards, and future plans

    Proceedings of The Multi-Agent Logics, Languages, and Organisations Federated Workshops (MALLOW 2010)

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    http://ceur-ws.org/Vol-627/allproceedings.pdfInternational audienceMALLOW-2010 is a third edition of a series initiated in 2007 in Durham, and pursued in 2009 in Turin. The objective, as initially stated, is to "provide a venue where: the cost of participation was minimum; participants were able to attend various workshops, so fostering collaboration and cross-fertilization; there was a friendly atmosphere and plenty of time for networking, by maximizing the time participants spent together"

    THE ROLE OF JAVANESE CULTURE IN CHARACTER BUILDING AT ELEMENTARY SCHOOL

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    Nowadays, character education becomes a major concern in Indonesia. Character development has been done by various strategy, but the results is yet to be seen. Character development should beginin elementary school in order that the children's charactercould formed early so that it could be developed until they are mature. One of the efforts of character building is integrating the local wisdom in learning. One of them is the Javanese culture. Javanese culture has a variety of rules called the "unggah-ungguh" that always give good models to the public community, especially to the Javanese. Along with the times, the Javanese culture that upholds ethics began to degraded and replaced by foreign cultures that came later. The parents’ roles in instilling the Javanese culture to their children also decreased gradually. This paper will examine the Javanese culture’s roles toward the character building in elementary schools’ students. Descriptive method supported by a depth review of the literature and the previous studies is used in this paper as a method. Based on the results of these reviews, we obtain some information about the types and mechanisms of Javanese culture in character building of students, especially elementary school students

    Measurement of service innovation project success:A practical tool and theoretical implications

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