Overnight consolidation aids the transfer of statistical knowledge from the medial temporal lobe to the striatum

Sleep is important for abstraction of the underlying principles (or gist) which bind together conceptually related stimuli, but little is known about the neural correlates of this process. Here, we investigate this issue using overnight sleep monitoring and functional magnetic resonance imaging (fMRI). Participants were exposed to a statistically structured sequence of auditory tones then tested immediately for recognition of short sequences which conformed to the learned statistical pattern. Subsequently, after consolidation over either 30min or 24h, they performed a delayed test session in which brain activity was monitored with fMRI. Behaviorally, there was greater improvement across 24h than across 30min, and this was predicted by the amount of slow wave sleep (SWS) obtained. Functionally, we observed weaker parahippocampal responses and stronger striatal responses after sleep. Like the behavioral result, these differences in functional response were predicted by the amount of SWS obtained. Furthermore, connectivity between striatum and parahippocampus was weaker after sleep, whereas connectivity between putamen and planum temporale was stronger. Taken together, these findings suggest that abstraction is associated with a gradual shift from the hippocampal to the striatal memory system and that this may be mediated by SWS

DOH: A Content Delivery Peer-to-Peer Network

Many SMEs and non-pro¯t organizations su®er when their Web servers become unavailable due to °ash crowd e®ects when their web site becomes popular. One of the solutions to the °ash-crowd problem is to place the web site on a scalable CDN (Content Delivery Network) that replicates the content and distributes the load in order to improve its response time. In this paper, we present our approach to building a scalable Web Hosting environment as a CDN on top of a structured peer-to-peer system of collaborative web-servers integrated to share the load and to improve the overall system performance, scalability, availability and robustness. Unlike clusterbased solutions, it can run on heterogeneous hardware, over geographically dispersed areas. To validate and evaluate our approach, we have developed a system prototype called DOH (DKS Organized Hosting) that is a CDN implemented on top of the DKS (Distributed K-nary Search) structured P2P system with DHT (Distributed Hash table) functionality [9]. The prototype is implemented in Java, using the DKS middleware, the Jetty web-server, and a modi¯ed JavaFTP server. The proposed design of CDN has been evaluated by simulation and by evaluation experiments on the prototype

Community Lynching and the US Asthma Epidemic

We explore the implications of IR Cohen's work on immune cognition for understanding rising rates of asthma morbidity and mortality in the US. Immune cognition is inherently linked with central nervous system cognition, and with the cognitive function of the embedding sociocultural networks by which individuals are acculturated and through which they work with others to meet challenges of threat and opportunity. Externally-imposed patterns of 'structured stress' can, through their effect on a child's socioculture, become synergistic with the development of immune cognition, triggering the persistence of an atopic Th2 phenotype, a necessary precursor to asthma and other immune diseases. Structured stress in the US particularly includes the cross sectional and longitudinal effects of a systematic destruction of minority urban communities occurring since the end of World War II which we characterize as community lynching. Reversal of the rising tide of asthma and related chronic diseases in the US thus seems unlikely without a 21st Century version of the earlier Great Urban Reforms which ended the scourge of infectious diseases, in particular an end to the de-facto ethnic cleansing of minority neighborhoo

Immune cognition, social justice and asthma: structured stress and the developing immune system

We explore the implications of IR Cohen's work on immune cognition for understanding rising rates of asthma morbidity and mortality in the US. Immune cognition is conjoined with central nervous system cognition, and with the cognitive function of the embedding sociocultural networks by which individuals are acculturated and through which they work with others to meet challenges of threat and opportunity. Using a mathematical model, we find that externally- imposed patterns of 'structured stress' can, through their effect on a child's socioculture, become synergistic with the development of immune cognition, triggering the persistence of an atopic Th2 phenotype, a necessary precursor to asthma and other immune disease. Reversal of the rising tide of asthma and related chronic diseases in the US thus seems unlikely without a 21st Century version of the earlier Great Urban Reforms which ended the scourge of infectious diseases

Optimally Efficient Prefix Search and Multicast in Structured P2P Networks

Searching in P2P networks is fundamental to all overlay networks. P2P networks based on Distributed Hash Tables (DHT) are optimized for single key lookups, whereas unstructured networks offer more complex queries at the cost of increased traffic and uncertain success rates. Our Distributed Tree Construction (DTC) approach enables structured P2P networks to perform prefix search, range queries, and multicast in an optimal way. It achieves this by creating a spanning tree over the peers in the search area, using only information available locally on each peer. Because DTC creates a spanning tree, it can query all the peers in the search area with a minimal number of messages. Furthermore, we show that the tree depth has the same upper bound as a regular DHT lookup which in turn guarantees fast and responsive runtime behavior. By placing objects with a region quadtree, we can perform a prefix search or a range query in a freely selectable area of the DHT. Our DTC algorithm is DHT-agnostic and works with most existing DHTs. We evaluate the performance of DTC over several DHTs by comparing the performance to existing application-level multicast solutions, we show that DTC sends 30-250% fewer messages than common solutions

Measuring and Managing Answer Quality for Online Data-Intensive Services

Online data-intensive services parallelize query execution across distributed software components. Interactive response time is a priority, so online query executions return answers without waiting for slow running components to finish. However, data from these slow components could lead to better answers. We propose Ubora, an approach to measure the effect of slow running components on the quality of answers. Ubora randomly samples online queries and executes them twice. The first execution elides data from slow components and provides fast online answers; the second execution waits for all components to complete. Ubora uses memoization to speed up mature executions by replaying network messages exchanged between components. Our systems-level implementation works for a wide range of platforms, including Hadoop/Yarn, Apache Lucene, the EasyRec Recommendation Engine, and the OpenEphyra question answering system. Ubora computes answer quality much faster than competing approaches that do not use memoization. With Ubora, we show that answer quality can and should be used to guide online admission control. Our adaptive controller processed 37% more queries than a competing controller guided by the rate of timeouts.Comment: Technical Repor

Network constraints on learnability of probabilistic motor sequences

Human learners are adept at grasping the complex relationships underlying incoming sequential input. In the present work, we formalize complex relationships as graph structures derived from temporal associations in motor sequences. Next, we explore the extent to which learners are sensitive to key variations in the topological properties inherent to those graph structures. Participants performed a probabilistic motor sequence task in which the order of button presses was determined by the traversal of graphs with modular, lattice-like, or random organization. Graph nodes each represented a unique button press and edges represented a transition between button presses. Results indicate that learning, indexed here by participants' response times, was strongly mediated by the graph's meso-scale organization, with modular graphs being associated with shorter response times than random and lattice graphs. Moreover, variations in a node's number of connections (degree) and a node's role in mediating long-distance communication (betweenness centrality) impacted graph learning, even after accounting for level of practice on that node. These results demonstrate that the graph architecture underlying temporal sequences of stimuli fundamentally constrains learning, and moreover that tools from network science provide a valuable framework for assessing how learners encode complex, temporally structured information.Comment: 29 pages, 4 figure