138,931 research outputs found
From Strangeness Enhancement to Quark-Gluon Plasma Discovery
This is a short survey of signatures and characteristics of the quark-gluon
plasma in the light of experimental results that have been obtained over the
past three decades. In particular, we present an in-depth discussion of the
strangeness observable, including a chronology of the experimental effort to
detect QGP at CERN-SPS, BNL-RHIC, and CERN-LHC.Comment: 30 pages, about 20 figures; Dedicated to our mentor Walter Greiner;
to be published in the memorial volume edited by Peter O. Hes
Strain-dependent host transcriptional responses to toxoplasma infection are largely conserved in mammalian and avian hosts
Toxoplasma gondii has a remarkable ability to infect an enormous variety of mammalian and avian species. Given this, it is surprising that three strains (Types I/II/III) account for the majority of isolates from Europe/North America. The selective pressures that have driven the emergence of these particular strains, however, remain enigmatic. We hypothesized that strain selection might be partially driven by adaptation of strains for mammalian versus avian hosts. To test this, we examine in vitro, strain-dependent host responses in fibroblasts of a representative avian host, the chicken (Gallus gallus). Using gene expression profiling of infected chicken embryonic fibroblasts and pathway analysis to assess host response, we show here that chicken cells respond with distinct transcriptional profiles upon infection with Type II versus III strains that are reminiscent of profiles observed in mammalian cells. To identify the parasite drivers of these differences, chicken fibroblasts were infected with individual F1 progeny of a Type II x III cross and host gene expression was assessed for each by microarray. QTL mapping of transcriptional differences suggested, and deletion strains confirmed, that, as in mammalian cells, the polymorphic rhoptry kinase ROP16 is the major driver of strain-specific responses. We originally hypothesized that comparing avian versus mammalian host response might reveal an inversion in parasite strain-dependent phenotypes; specifically, for polymorphic effectors like ROP16, we hypothesized that the allele with most activity in mammalian cells might be less active in avian cells. Instead, we found that activity of ROP16 alleles appears to be conserved across host species; moreover, additional parasite loci that were previously mapped for strain-specific effects on mammalian response showed similar strain-specific effects in chicken cells. These results indicate that if different hosts select for different parasite genotypes, the selection operates downstream of the signaling occurring during the beginning of the host's immune response. © 2011 Ong et al
Exploratory study to explore the role of ICT in the process of knowledge management in an Indian business environment
In the 21st century and the emergence of a digital economy, knowledge and the knowledge base economy are rapidly growing. To effectively be able to understand the processes involved in the creating, managing and sharing of knowledge management in the business environment is critical to the success of an organization. This study builds on the previous research of the authors on the enablers of knowledge management by identifying the relationship between the enablers of knowledge management and the role played by information communication technologies (ICT) and ICT infrastructure in a business setting. This paper provides the findings of a survey collected from the four major Indian cities (Chennai, Coimbatore, Madurai and Villupuram) regarding their views and opinions about the enablers of knowledge management in business setting. A total of 80 organizations participated in the study with 100 participants in each city. The results show that ICT and ICT infrastructure can play a critical role in the creating, managing and sharing of knowledge in an Indian business environment
The Doppler Shadow of WASP-3b: A tomographic analysis of Rossiter-McLaughlin observations
Hot-Jupiter planets must form at large separations from their host stars
where the temperatures are cool enough for their cores to condense. They then
migrate inwards to their current observed orbital separations. Different
theories of how this migration occurs lead to varying distributions of orbital
eccentricity and the alignment between the rotation axis of the star and the
orbital axis of the planet. The spin-orbit alignment of a transiting system is
revealed via the Rossiter-McLaughlin effect, which is the anomaly present in
the radial velocity measurements of the rotating star during transit due to the
planet blocking some of the starlight. In this paper we aim to measure the
spin-orbit alignment of the WASP-3 system via a new way of analysing the
Rossiter-McLaughlin observations. We apply a new tomographic method for
analysing the time variable asymmetry of stellar line profiles caused by the
Rossiter-McLaughlin effect. This new method eliminates the systematic error
inherent in previous methods used to analyse the effect. We find a value for
the projected stellar spin rate of v sin i = 13.9 \pm 0.03 km/s which is in
agreement with previous measurements but has a much higher precision. The
system is found to be well aligned which favours an evolutionary history for
WASP-3b involving migration through tidal interactions with a protoplanetary
disc. Using gyrochronology we estimate the age of the star to be ~300 Myr with
an upper limit of 2 Gyr from comparison with isochrones.Comment: Accepted for publication in A&A, 8 pages, 4 figures, 2 table
Do not trust me: Using malicious IdPs for analyzing and attacking Single Sign-On
Single Sign-On (SSO) systems simplify login procedures by using an an
Identity Provider (IdP) to issue authentication tokens which can be consumed by
Service Providers (SPs). Traditionally, IdPs are modeled as trusted third
parties. This is reasonable for SSO systems like Kerberos, MS Passport and
SAML, where each SP explicitely specifies which IdP he trusts. However, in open
systems like OpenID and OpenID Connect, each user may set up his own IdP, and a
discovery phase is added to the protocol flow. Thus it is easy for an attacker
to set up its own IdP. In this paper we use a novel approach for analyzing SSO
authentication schemes by introducing a malicious IdP. With this approach we
evaluate one of the most popular and widely deployed SSO protocols - OpenID. We
found four novel attack classes on OpenID, which were not covered by previous
research, and show their applicability to real-life implementations. As a
result, we were able to compromise 11 out of 16 existing OpenID implementations
like Sourceforge, Drupal and ownCloud. We automated discovery of these attacks
in a open source tool OpenID Attacker, which additionally allows fine-granular
testing of all parameters in OpenID implementations. Our research helps to
better understand the message flow in the OpenID protocol, trust assumptions in
the different components of the system, and implementation issues in OpenID
components. It is applicable to other SSO systems like OpenID Connect and SAML.
All OpenID implementations have been informed about their vulnerabilities and
we supported them in fixing the issues
Independent Confirmation of the Pioneer 10 Anomalous Acceleration
I perform an independent analysis of radio Doppler tracking data from the
Pioneer 10 spacecraft for the time period 1987-1994. All of the tracking data
were taken from public archive sources, and the analysis tools were developed
independently by myself. I confirm that an apparent anomalous acceleration is
acting on the Pioneer 10 spacecraft, which is not accounted for by present
physical models of spacecraft navigation. My best fit value for the
acceleration, including corrections for systematic biases and uncertainties, is
(8.60 +/- 1.34) x 10^{-8} cm s^{-2}, directed towards the Sun. This value
compares favorably to previous results. I examine the robustness of my result
to various perturbations of the analysis method, and find agreement to within
+/- 5%. The anomalous acceleration is reasonably constant with time, with a
characteristic variation time scale of > 70 yr. Such a variation timescale is
still too short to rule out on-board thermal radiation effects, based on this
particular Pioneer 10 data set.Comment: RevTeX, 29 pages, 5 figures, submitted to Phys Rev
- …