SIRENA: A CAD environment for behavioural modelling and simulation of VLSI cellular neural network chips

This paper presents SIRENA, a CAD environment for the simulation and modelling of mixed-signal VLSI parallel processing chips based on cellular neural networks. SIRENA includes capabilities for: (a) the description of nominal and non-ideal operation of CNN analogue circuitry at the behavioural level; (b) performing realistic simulations of the transient evolution of physical CNNs including deviations due to second-order effects of the hardware; and, (c) evaluating sensitivity figures, and realize noise and Monte Carlo simulations in the time domain. These capabilities portray SIRENA as better suited for CNN chip development than algorithmic simulation packages (such as OpenSimulator, Sesame) or conventional neural networks simulators (RCS, GENESIS, SFINX), which are not oriented to the evaluation of hardware non-idealities. As compared to conventional electrical simulators (such as HSPICE or ELDO-FAS), SIRENA provides easier modelling of the hardware parasitics, a significant reduction in computation time, and similar accuracy levels. Consequently, iteration during the design procedure becomes possible, supporting decision making regarding design strategies and dimensioning. SIRENA has been developed using object-oriented programming techniques in C, and currently runs under the UNIX operating system and X-Windows framework. It employs a dedicated high-level hardware description language: DECEL, fitted to the description of non-idealities arising in CNN hardware. This language has been developed aiming generality, in the sense of making no restrictions on the network models that can be implemented. SIRENA is highly modular and composed of independent tools. This simplifies future expansions and improvements.Comisión Interministerial de Ciencia y Tecnología TIC96-1392-C02-0

Resting state connectivity between medial temporal lobe regions and intrinsic cortical networks predicts performance in a path integration task

Humans differ in their individual navigational performance, in part because successful navigation relies on several diverse abilities. One such navigational capability is path integration, the updating of position and orientation during movement, typically in a sparse, landmark-free environment. This study examined the relationship between path integration abilities and functional connectivity to several canonical intrinsic brain networks. Intrinsic networks within the brain reflect past inputs and communication as well as structural architecture. Individual differences in intrinsic connectivity have been observed for common networks, suggesting that these networks can inform our understanding of individual spatial abilities. Here, we examined individual differences in intrinsic connectivity using resting state magnetic resonance imaging (rsMRI). We tested path integration ability using a loop closure task, in which participants viewed a single video of movement in a circle trajectory in a sparse environment, and then indicated whether the video ended in the same location in which it started. To examine intrinsic brain networks, participants underwent a resting state scan. We found that better performance in the loop task was associated with increased connectivity during rest between the central executive network (CEN) and posterior hippocampus, parahippocampal cortex (PHC) and entorhinal cortex. We also found that connectivity between PHC and the default mode network (DMN) during rest was associated with better loop closure performance. The results indicate that interactions between medial temporal lobe (MTL) regions and intrinsic networks that involve prefrontal cortex (PFC) are important for path integration and navigation.This work was supported by the Office of Naval Research (ONR MURI N00014-10-1-0936 and MURI N00014-16-1-2832). fMRI scanning was completed at the Athinoula A. Martinos Center for Biomedical Imaging (Charlestown, MA, USA), which receives support from the National Center for Research Resources (NCRR P41RR14075). (ONR MURI N00014-10-1-0936 - Office of Naval Research; MURI N00014-16-1-2832 - Office of Naval Research; NCRR P41RR14075 - National Center for Research Resources)Published versio

PCA-ANN Face Recognition System based on Photometric Normalization Techniques

The human face is the main focus of attention in social interaction, and is also the major key in conveying identity and emotion of a person. It has the appealing characteristic of not being intrusive as compared with other biometric techniques. The research works on face recognition started in the 1960s with the pioneering work of Bledsoe and Kanade, wh

A SIFT-Based Fingerprint Verification System Using Cellular Neural Networks

Recently, with the increasing demand of high security, person identification has become more and more important in our everyday life. The purpose of establishing the identity is to ensure that only a legitimate user, and not anyone else, accesses the rendered services. The traditional identification methods are based on “something that you possess ” and “somethin

Color image processing in a cellular neural-network environment

When low-level hardware simulations of cellular neural networks (CNNs) are very costly for exploring new applications, the use of a behavioral simulator becomes indispensable. This paper presents a software prototype capable of performing image processing applications using CNNs. The software is based on a CNN multilayer structure in which each primary color is assigned to a unique layer. This allows an added flexibility as different processing applications can be performed in parallel. To be able to handle a full range of color tones, two novel color mapping schemes were derived. In the proposed schemes the color information is obtained from the cell's state rather than from its output. This modification is necessary because for many templates CNN has only binary stable outputs from which only either a fully saturated or a black color can be obtained. Additionally, a postprocessor capable of performing pixelwise logical operations among color layers was developed to enhance the results obtained from CNN. Examples in the areas of medical image processing, image restoration, and weather forecasting are provided to demonstrate the robustness of the software and the vast potential of CN

Cellular Simultanous Recurrent Networks for Image Processing

Artificial neural networks are inspired by the abilities of humans and animals to learn and adapt. Feed-forward networks are both fast and powerful, and are particularly useful for statistical pattern recognition. These networks are inspired by portions of the brain such as the visual cortex. However, feed-forward networks have been shown inadequate for complex applications such as long-term optimization, reinforced learning and image processing. Cellular Neural Networks (CNNs) are a type of recurrent network which have been used extensively for image processing. CNNs have shown limited success solving problems which involve topological relationships. Such problems include geometric transformations such as affine transformation and image registration. The Cellular Simultaneous Recurrent Network (CSRN) has been exploited to solve the 2D maze traversal problem, which is a long-term optimization problem with similar topological relations. From its inception, it has been speculated that the CSRN may have important implications in image processing. However, to date, very little work has been done to study CSRNs for image processing tasks. In this work, we investigate CSRNs for image processing. We propose a novel, generalized architecture for the CSRN suitable for generic image processing tasks. This architecture includes the use of sub-image processing which greatly improves the efficacy of CSRNs for image processing. We demonstrate the application of the CSRN with this generalized architecture across a variety of image processing problems including pixel level transformations, filtering, and geometric transformations. Results are evaluated and compared with standard MATLAB® functions. To better understand the inner workings of the CSRN we investigate the use of various CSRN cores including: 1) the original Generalized Multi-Layered Perceptron (GMLP) core used by Pang and Werbos to solve the 2D maze traversal problem, 2) the Elman Simultaneous Recurrent Network (ESRN), and 3) a novel ESRN core with multi-layered feedback. We compare the functionality of these cores in image processing applications. Further, we introduce the application of the unscented Kalman filter (UKF) for training of the CSRN. Results are compared with the standard Extended Kalman Filter (EKF) training method of CSRN. Finally, implications of current findings and proposed research directions are presented

Split and Shift Methodology: Overcoming Hardware Limitations on Cellular Processor Arrays for Image Processing

Na era multimedia, o procesado de imaxe converteuse nun elemento de singular importancia nos dispositivos electrónicos. Dende as comunicacións (p.e. telemedicina), a seguranza (p.e. recoñecemento retiniano) ou control de calidade e de procesos industriais (p.e. orientación de brazos articulados, detección de defectos do produto), pasando pola investigación (p.e. seguimento de partículas elementais) e diagnose médica (p.e. detección de células estrañas, identificaciónn de veas retinianas), hai un sinfín de aplicacións onde o tratamento e interpretación automáticas de imaxe e fundamental. O obxectivo último será o deseño de sistemas de visión con capacidade de decisión. As tendencias actuais requiren, ademais, a combinación destas capacidades en dispositivos pequenos e portátiles con resposta en tempo real. Isto propón novos desafíos tanto no deseño hardware como software para o procesado de imaxe, buscando novas estruturas ou arquitecturas coa menor area e consumo de enerxía posibles sen comprometer a funcionalidade e o rendemento

Cell-Free Synthetic Biology Platform for Engineering Synthetic Biological Circuits and Systems

Synthetic biology brings engineering disciplines to create novel biological systems for biomedical and technological applications. The substantial growth of the synthetic biology field in the past decade is poised to transform biotechnology and medicine. To streamline design processes and facilitate debugging of complex synthetic circuits, cell-free synthetic biology approaches has reached broad research communities both in academia and industry. By recapitulating gene expression systems in vitro, cell-free expression systems offer flexibility to explore beyond the confines of living cells and allow networking of synthetic and natural systems. Here, we review the capabilities of the current cell-free platforms, focusing on nucleic acid-based molecular programs and circuit construction. We survey the recent developments including cell-free transcription– translation platforms, DNA nanostructures and circuits, and novel classes of riboregulators. The links to mathematical models and the prospects of cell-free synthetic biology platforms will also be discussed.11Yscopu

Human 3D cellular model of hypoxic brain injury of prematurity.

Owing to recent medical and technological advances in neonatal care, infants born extremely premature have increased survival rates1,2. After birth, these infants are at high risk of hypoxic episodes because of lung immaturity, hypotension and lack of cerebral-flow regulation, and can develop a severe condition called encephalopathy of prematurity3. Over 80% of infants born before post-conception week 25 have moderate-to-severe long-term neurodevelopmental impairments4. The susceptible cell types in the cerebral cortex and the molecular mechanisms underlying associated gray-matter defects in premature infants remain unknown. Here we used human three-dimensional brain-region-specific organoids to study the effect of oxygen deprivation on corticogenesis. We identified specific defects in intermediate progenitors, a cortical cell type associated with the expansion of the human cerebral cortex, and showed that these are related to the unfolded protein response and changes. Moreover, we verified these findings in human primary cortical tissue and demonstrated that a small-molecule modulator of the unfolded protein response pathway can prevent the reduction in intermediate progenitors following hypoxia. We anticipate that this human cellular platform will be valuable for studying the environmental and genetic factors underlying injury in the developing human brain

Microarray image processing: A novel neural network framework

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Due to the vast success of bioengineering techniques, a series of large-scale analysis tools has been developed to discover the functional organization of cells. Among them, cDNA microarray has emerged as a powerful technology that enables biologists to cDNA microarray technology has enabled biologists to study thousands of genes simultaneously within an entire organism, and thus obtain a better understanding of the gene interaction and regulation mechanisms involved. Although microarray technology has been developed so as to offer high tolerances, there exists high signal irregularity through the surface of the microarray image. The imperfection in the microarray image generation process causes noises of many types, which contaminate the resulting image. These errors and noises will propagate down through, and can significantly affect, all subsequent processing and analysis. Therefore, to realize the potential of such technology it is crucial to obtain high quality image data that would indeed reflect the underlying biology in the samples. One of the key steps in extracting information from a microarray image is segmentation: identifying which pixels within an image represent which gene. This area of spotted microarray image analysis has received relatively little attention relative to the advances in proceeding analysis stages. But, the lack of advanced image analysis, including the segmentation, results in sub-optimal data being used in all downstream analysis methods. Although there is recently much research on microarray image analysis with many methods have been proposed, some methods produce better results than others. In general, the most effective approaches require considerable run time (processing) power to process an entire image. Furthermore, there has been little progress on developing sufficiently fast yet efficient and effective algorithms the segmentation of the microarray image by using a highly sophisticated framework such as Cellular Neural Networks (CNNs). It is, therefore, the aim of this thesis to investigate and develop novel methods processing microarray images. The goal is to produce results that outperform the currently available approaches in terms of PSNR, k-means and ICC measurements.Aleppo University, Syri