Real-Time Magnetic Resonance Imaging

Real‐time magnetic resonance imaging (RT‐MRI) allows for imaging dynamic processes as they occur, without relying on any repetition or synchronization. This is made possible by modern MRI technology such as fast‐switching gradients and parallel imaging. It is compatible with many (but not all) MRI sequences, including spoiled gradient echo, balanced steady‐state free precession, and single‐shot rapid acquisition with relaxation enhancement. RT‐MRI has earned an important role in both diagnostic imaging and image guidance of invasive procedures. Its unique diagnostic value is prominent in areas of the body that undergo substantial and often irregular motion, such as the heart, gastrointestinal system, upper airway vocal tract, and joints. Its value in interventional procedure guidance is prominent for procedures that require multiple forms of soft‐tissue contrast, as well as flow information. In this review, we discuss the history of RT‐MRI, fundamental tradeoffs, enabling technology, established applications, and current trends

Cardiac magnetic resonance assessment of central and peripheral vascular function in patients undergoing renal sympathetic denervation as predictor for blood pressure response

Background: Most trials regarding catheter-based renal sympathetic denervation (RDN) describe a proportion of patients without blood pressure response. Recently, we were able to show arterial stiffness, measured by invasive pulse wave velocity (IPWV), seems to be an excellent predictor for blood pressure response. However, given the invasiveness, IPWV is less suitable as a selection criterion for patients undergoing RDN. Consequently, we aimed to investigate the value of cardiac magnetic resonance (CMR) based measures of arterial stiffness in predicting the outcome of RDN compared to IPWV as reference. Methods: Patients underwent CMR prior to RDN to assess ascending aortic distensibility (AAD), total arterial compliance (TAC), and systemic vascular resistance (SVR). In a second step, central aortic blood pressure was estimated from ascending aortic area change and flow sequences and used to re-calculate total arterial compliance (cTAC). Additionally, IPWV was acquired. Results: Thirty-two patients (24 responders and 8 non-responders) were available for analysis. AAD, TAC and cTAC were higher in responders, IPWV was higher in non-responders. SVR was not different between the groups. Patients with AAD, cTAC or TAC above median and IPWV below median had significantly better BP response. Receiver operating characteristic (ROC) curves predicting blood pressure response for IPWV, AAD, cTAC and TAC revealed areas under the curve of 0.849, 0.828, 0.776 and 0.753 (p = 0.004, 0.006, 0.021 and 0.035). Conclusions: Beyond IPWV, AAD, cTAC and TAC appear as useful outcome predictors for RDN in patients with hypertension. CMR-derived markers of arterial stiffness might serve as non-invasive selection criteria for RDN

Compressive Sensing and Its Applications in Automotive Radar Systems

Die Entwicklung in Richtung zu autonomem Fahren verspricht, künftig einen sicheren Verkehr ohne tödliche Unfälle zu ermöglichen, indem menschliche Fahrer vollständig ersetzt werden. Dadurch entfällt der Faktor des menschlichen Fehlers, der aus Müdigkeit, Unachtsamkeit oder Alkoholeinfluss resultiert. Um jedoch eine breite Akzeptanz für autonome Fahrzeuge zu erreichen und es somit eines Tages vollständig umzusetzen, sind noch eine Vielzahl von Herausforderungen zu lösen. Da in einem autonomen Fahrzeug kein menschlicher Fahrer mehr in Notfällen eingreifen kann, müssen sich autonome Fahrzeuge auf leistungsfähige und robuste Sensorsysteme verlassen können, um in kritischen Situationen auch unter widrigen Bedingungen angemessen reagieren zu können. Daher ist die Entwicklung von Sensorsystemen erforderlich, die für Funktionalitäten jenseits der aktuellen advanced driver assistance systems eingesetzt werden können. Dies resultiert in neuen Anforderungen, die erfüllt werden müssen, um sichere und zuverlässige autonome Fahrzeuge zu realisieren, die weder Fahrzeuginsassen noch Passanten gefährden. Radarsysteme gehören zu den Schlüsselkomponenten unter der Vielzahl der verfügbaren Sensorsysteme, da sie im Gegensatz zu visuellen Sensoren von widrigen Wetter- und Umgebungsbedingungen kaum beeinträchtigt werden. Darüber hinaus liefern Radarsysteme zusätzliche Umgebungsinformationen wie Abstand, Winkel und relative Geschwindigkeit zwischen Sensor und reflektierenden Zielen. Die vorliegende Dissertation deckt im Wesentlichen zwei Hauptaspekte der Forschung und Entwicklung auf dem Gebiet der Radarsysteme im Automobilbereich ab. Ein Aspekt ist die Steigerung der Effizienz und Robustheit der Signalerfassung und -verarbeitung für die Radarperzeption. Der andere Aspekt ist die Beschleunigung der Validierung und Verifizierung von automated cyber-physical systems, die parallel zum Automatisierungsgrad auch eine höhere Komplexität aufweisen. Nach der Analyse zahlreicher möglicher Compressive Sensing Methoden, die im Bereich Fahrzeugradarsysteme angewendet werden können, wird ein rauschmoduliertes gepulstes Radarsystem vorgestellt, das kommerzielle Fahrzeugradarsysteme in seiner Robustheit gegenüber Rauschen übertrifft. Die Nachteile anderer gepulster Radarsysteme hinsichtlich des Signalerfassungsaufwands und der Laufzeit werden durch die Verwendung eines Compressive Sensing-Signalerfassungs- und Rekonstruktionsverfahrens in Kombination mit einer Rauschmodulation deutlich verringert. Mit Compressive Sensing konnte der Aufwand für die Signalerfassung um 70% reduziert werden, während gleichzeitig die Robustheit der Radarwahrnehmung auch für signal-to-noise-ratio-Pegel nahe oder unter Null erreicht wird. Mit einem validierten Radarsensormodell wurde das Rauschradarsystem emuliert und mit einem kommerziellen Fahrzeugradarsystem verglichen. Datengetriebene Wettermodelle wurden entwickelt und während der Simulation angewendet, um die Radarleistung unter widrigen Bedingungen zu bewerten. Während eine Besprühung mit Wasser die Radomdämpfung um 10 dB erhöht und Spritzwasser sogar um 20 dB, ergibt sich die eigentliche Begrenzung aus der Rauschzahl und Empfindlichkeit des Empfängers. Es konnte bewiesen werden, dass das vorgeschlagene Compressive Sensing Rauschradarsystem mit einer zusätzlichen Signaldämpfung von bis zu 60 dB umgehen kann und damit eine hohe Robustheit in ungünstigen Umwelt- und Wetterbedingungen aufweist. Neben der Robustheit wird auch die Interferenz berücksichtigt. Zum einen wird die erhöhte Störfestigkeit des Störradarsystems nachgewiesen. Auf der anderen Seite werden die Auswirkungen auf bestehende Fahrzeugradarsysteme bewertet und Strategien zur Minderung der Auswirkungen vorgestellt. Die Struktur der Arbeit ist folgende. Nach der Einführung der Grundlagen und Methoden für Fahrzeugradarsysteme werden die Theorie und Metriken hinter Compressive Sensing gezeigt. Darüber hinaus werden weitere Aspekte wie Umgebungsbedingungen, unterschiedliche Radararchitekturen und Interferenz erläutert. Der Stand der Technik gibt einen Überblick über Compressive Sensing-Ansätze und Implementierungen mit einem Fokus auf Radar. Darüber hinaus werden Aspekte von Fahrzeug- und Rauschradarsystemen behandelt. Der Hauptteil beginnt mit der Vorstellung verschiedener Ansätze zur Nutzung von Compressive Sensing für Fahrzeugradarsysteme, die in der Lage sind, die Erfassung und Wahrnehmung von Radarsignalen zu verbessern oder zu erweitern. Anschließend wird der Fokus auf ein Rauschradarsystem gelegt, das mit Compressive Sensing eine effiziente Signalerfassung und -rekonstruktion ermöglicht. Es wurde mit verschiedenen Compressive Sensing-Metriken analysiert und in einer Proof-of-Concept-Simulation bewertet. Mit einer Emulation des Rauschradarsystems wurde das Potential der Compressive Sensing Signalerfassung und -verarbeitung in einem realistischeren Szenario demonstriert. Die Entwicklung und Validierung des zugrunde liegenden Sensormodells wird ebenso dokumentiert wie die Entwicklung der datengetriebenen Wettermodelle. Nach der Betrachtung von Interferenz und der Koexistenz des Rauschradars mit kommerziellen Radarsystemen schließt ein letztes Kapitel mit Schlussfolgerungen und einem Ausblick die Arbeit ab.Developments towards autonomous driving promise to lead to safer traffic, where fatal accidents can be avoided after making human drivers obsolete and hence removing the factor of human error. However, to ensure the acceptance of automated driving and make it a reality one day, still a huge amount of challenges need to be solved. With having no human supervisors, automated vehicles have to rely on capable and robust sensor systems to ensure adequate reactions in critical situations, even during adverse conditions. Therefore, the development of sensor systems is required that can be applied for functionalities beyond current advanced driver assistance systems. New requirements need to be met in order to realize safe and reliable automated vehicles that do not harm passersby. Radar systems belong to the key components among the variety of sensor systems. Other than visual sensors, radar is less vulnerable towards adverse weather and environment conditions. In addition, radar provides complementary environment information such as target distance, angular position or relative velocity, too. The thesis ad hand covers basically two main aspects of research and development in the field of automotive radar systems. One aspect is to increase efficiency and robustness in signal acquisition and processing for radar perception. The other aspect is to accelerate validation and verification of automated cyber-physical systems that feature more complexity along with the level of automation. After analyzing a variety of possible Compressive Sensing methods for automotive radar systems, a noise modulated pulsed radar system is suggested in the thesis at hand, which outperforms commercial automotive radar systems in its robustness towards noise. Compared to other pulsed radar systems, their drawbacks regarding signal acquisition effort and computation run time are resolved by using noise modulation for implementing a Compressive Sensing signal acquisition and reconstruction method. Using Compressive Sensing, the effort in signal acquisition was reduced by 70%, while obtaining a radar perception robustness even for signal-to-noise-ratio levels close to or below zero. With a validated radar sensor model the noise radar was emulated and compared to a commercial automotive radar system. Data-driven weather models were developed and applied during simulation to evaluate radar performance in adverse conditions. While water sprinkles increase radome attenuation by 10 dB and splash water even by 20 dB, the actual limitation comes from noise figure and sensitivity of the receiver. The additional signal attenuation that can be handled by the proposed compressive sensing noise radar system proved to be even up to 60 dB, which ensures a high robustness of the receiver during adverse weather and environment conditions. Besides robustness, interference is also considered. On the one hand the increased robustness towards interference of the noise radar system is demonstrated. On the other hand, the impact on existing automotive radar systems is evaluated and strategies to mitigate the impact are presented. The structure of the thesis is the following. After introducing basic principles and methods for automotive radar systems, the theory and metrics of Compressive Sensing is presented. Furthermore some particular aspects are highlighted such as environmental conditions, different radar architectures and interference. The state of the art provides an overview on Compressive Sensing approaches and implementations with focus on radar. In addition, it covers automotive radar and noise radar related aspects. The main part starts with presenting different approaches on making use of Compressive Sensing for automotive radar systems, that are capable of either improving or extending radar signal acquisition and perception. Afterwards the focus is put on a noise radar system that uses Compressive Sensing for an efficient signal acquisition and reconstruction. It was analyzed using different Compressive Sensing metrics and evaluated in a proof-of-concept simulation. With an emulation of the noise radar system the feasibility of the Compressive Sensing signal acquisition and processing was demonstrated in a more realistic scenario. The development and validation of the underlying sensor model is documented as well as the development of the data-driven weather models. After considering interference and co-existence with commercial radar systems, a final chapter with conclusions and an outlook completes the work

Intelligent Biosignal Processing in Wearable and Implantable Sensors

This reprint provides a collection of papers illustrating the state-of-the-art of smart processing of data coming from wearable, implantable or portable sensors. Each paper presents the design, databases used, methodological background, obtained results, and their interpretation for biomedical applications. Revealing examples are brain–machine interfaces for medical rehabilitation, the evaluation of sympathetic nerve activity, a novel automated diagnostic tool based on ECG data to diagnose COVID-19, machine learning-based hypertension risk assessment by means of photoplethysmography and electrocardiography signals, Parkinsonian gait assessment using machine learning tools, thorough analysis of compressive sensing of ECG signals, development of a nanotechnology application for decoding vagus-nerve activity, detection of liver dysfunction using a wearable electronic nose system, prosthetic hand control using surface electromyography, epileptic seizure detection using a CNN, and premature ventricular contraction detection using deep metric learning. Thus, this reprint presents significant clinical applications as well as valuable new research issues, providing current illustrations of this new field of research by addressing the promises, challenges, and hurdles associated with the synergy of biosignal processing and AI through 16 different pertinent studies. Covering a wide range of research and application areas, this book is an excellent resource for researchers, physicians, academics, and PhD or master students working on (bio)signal and image processing, AI, biomaterials, biomechanics, and biotechnology with applications in medicine

Intelligent Sensor Networks

In the last decade, wireless or wired sensor networks have attracted much attention. However, most designs target general sensor network issues including protocol stack (routing, MAC, etc.) and security issues. This book focuses on the close integration of sensing, networking, and smart signal processing via machine learning. Based on their world-class research, the authors present the fundamentals of intelligent sensor networks. They cover sensing and sampling, distributed signal processing, and intelligent signal learning. In addition, they present cutting-edge research results from leading experts

Magnetoelectric Sensor Systems and Applications

In the field of magnetic sensing, a wide variety of different magnetometer and gradiometer sensor types, as well as the corresponding read-out concepts, are available. Well-established sensor concepts such as Hall sensors and magnetoresistive sensors based on giant magnetoresistances (and many more) have been researched for decades. The development of these types of sensors has reached maturity in many aspects (e.g., performance metrics, reliability, and physical understanding), and these types of sensors are established in a large variety of industrial applications. Magnetic sensors based on the magnetoelectric effect are a relatively new type of magnetic sensor. The potential of magnetoelectric sensors has not yet been fully investigated. Especially in biomedical applications, magnetoelectric sensors show several advantages compared to other concepts for their ability, for example, to operate in magnetically unshielded environments and the absence of required cooling or heating systems. In recent years, research has focused on understanding the different aspects influencing the performance of magnetoelectric sensors. At Kiel University, Germany, the Collaborative Research Center 1261 “Magnetoelectric Sensors: From Composite Materials to Biomagnetic Diagnostics”, funded by the German Research Foundation, has dedicated its work to establishing a fundamental understanding of magnetoelectric sensors and their performance parameters, pushing the performance of magnetoelectric sensors to the limits and establishing full magnetoelectric sensor systems in biological and clinical practice

Asynchronous Representation and Processing of Analog Sparse Signals Using a Time-Scale Framework

In this dissertation we investigate the problem of asynchronous representation and processing of analog sparse signals using a time-scale framework. Recently, in the design of signal representations the focus has been on the use of application-driven constraints for optimality purposes. Appearing in many fields such as neuroscience, implantable biomedical diagnostic devices, and sensor network applications, sparse or burst--like signals are of great interest. A common challenge in the representation of such signals is that they exhibit non--stationary behavior with frequency--varying spectra. By ignoring that the maximum frequency of their spectra is changing with time, uniformly sampling sparse signals collects samples in quiescent segments and results in high power dissipation. Also, continuous monitoring of signals challenges data acquisition, storage, and processing; especially if remote monitoring is desired, as this would require that a large number of samples be generated, stored and transmitted. Power consumption and the type of processing imposed by the size of the devices in the aforementioned applications has motivated the use of asynchronous approaches in our research. First, we work on establishing a new paradigm for the representation of analog sparse signals using a time-frequency representation. Second, we develop a scale-based signal decomposition framework which uses filter-bank structures for the representation-analysis-compression scheme of the sparse information. Using an asynchronous signal decomposition scheme leads to reduced computational requirements and lower power consumption; thus it is promising for hardware implementation. In addition, the proposed algorithm does not require prior knowledge of the bandwidth of the signal and the effect of noise can still be alleviated. Finally, we consider the synthesis step, where the target signal is reconstructed from compressed data. We implement a perfect reconstruction filter bank based on Slepian wavelets to use in the reconstruction of sparse signals from non--uniform samples. In this work, experiments on primary biomedical signal applications, such as electrocardiogram (EEG), swallowing signals and heart sound recordings have achieved significant improvements over traditional methods in the sensing and processing of sparse data. The results are also promising in applications including compression and denoising

Ultrafast Ultrasound Imaging

Among medical imaging modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI), ultrasound imaging stands out due to its temporal resolution. Owing to the nature of medical ultrasound imaging, it has been used for not only observation of the morphology of living organs but also functional imaging, such as blood flow imaging and evaluation of the cardiac function. Ultrafast ultrasound imaging, which has recently become widely available, significantly increases the opportunities for medical functional imaging. Ultrafast ultrasound imaging typically enables imaging frame-rates of up to ten thousand frames per second (fps). Due to the extremely high temporal resolution, this enables visualization of rapid dynamic responses of biological tissues, which cannot be observed and analyzed by conventional ultrasound imaging. This Special Issue includes various studies of improvements to the performance of ultrafast ultrasoun

Advanced Knowledge Application in Practice

The integration and interdependency of the world economy leads towards the creation of a global market that offers more opportunities, but is also more complex and competitive than ever before. Therefore widespread research activity is necessary if one is to remain successful on the market. This book is the result of research and development activities from a number of researchers worldwide, covering concrete fields of research

Hardware-software design of embedded systems for intelligent sensing applications

This Thesis wants to highlight the importance of ad-hoc designed and developed embedded systems in the implementation of intelligent sensor networks. As evidence four areas of application are presented: Precision Agriculture, Bioengineering, Automotive and Structural Health Monitoring. For each field is reported one, or more, smart device design and developing, in addition to on-board elaborations, experimental validation and in field tests. In particular, it is presented the design and development of a fruit meter. In the bioengineering field, three different projects are reported, detailing the architectures implemented and the validation tests conducted. Two prototype realizations of an inner temperature measurement system in electric motors for an automotive application are then discussed. Lastly, the HW/SW design of a Smart Sensor Network is analyzed: the network features on-board data management and processing, integration in an IoT toolchain, Wireless Sensor Network developments and an AI framework for vibration-based structural assessment