162,709 research outputs found
The prospect of using LES and DES in engineering design, and the research required to get there
In this paper we try to look into the future to divine how large eddy and
detached eddy simulations (LES and DES, respectively) will be used in the
engineering design process about 20-30 years from now. Some key challenges
specific to the engineering design process are identified, and some of the
critical outstanding problems and promising research directions are discussed.Comment: accepted for publication in the Royal Society Philosophical
Transactions
Adversarial Sample Detection for Deep Neural Network through Model Mutation Testing
Deep neural networks (DNN) have been shown to be useful in a wide range of
applications. However, they are also known to be vulnerable to adversarial
samples. By transforming a normal sample with some carefully crafted human
imperceptible perturbations, even highly accurate DNN make wrong decisions.
Multiple defense mechanisms have been proposed which aim to hinder the
generation of such adversarial samples. However, a recent work show that most
of them are ineffective. In this work, we propose an alternative approach to
detect adversarial samples at runtime. Our main observation is that adversarial
samples are much more sensitive than normal samples if we impose random
mutations on the DNN. We thus first propose a measure of `sensitivity' and show
empirically that normal samples and adversarial samples have distinguishable
sensitivity. We then integrate statistical hypothesis testing and model
mutation testing to check whether an input sample is likely to be normal or
adversarial at runtime by measuring its sensitivity. We evaluated our approach
on the MNIST and CIFAR10 datasets. The results show that our approach detects
adversarial samples generated by state-of-the-art attacking methods efficiently
and accurately.Comment: Accepted by ICSE 201
Prediction of protein-protein interactions using one-class classification methods and integrating diverse data
This research addresses the problem of prediction of protein-protein interactions (PPI)
when integrating diverse kinds of biological information. This task has been commonly
viewed as a binary classification problem (whether any two proteins do or do not interact)
and several different machine learning techniques have been employed to solve this
task. However the nature of the data creates two major problems which can affect results.
These are firstly imbalanced class problems due to the number of positive examples (pairs
of proteins which really interact) being much smaller than the number of negative ones.
Secondly the selection of negative examples can be based on some unreliable assumptions
which could introduce some bias in the classification results.
Here we propose the use of one-class classification (OCC) methods to deal with the task of
prediction of PPI. OCC methods utilise examples of just one class to generate a predictive
model which consequently is independent of the kind of negative examples selected; additionally
these approaches are known to cope with imbalanced class problems. We have
designed and carried out a performance evaluation study of several OCC methods for this
task, and have found that the Parzen density estimation approach outperforms the rest. We
also undertook a comparative performance evaluation between the Parzen OCC method
and several conventional learning techniques, considering different scenarios, for example
varying the number of negative examples used for training purposes. We found that the
Parzen OCC method in general performs competitively with traditional approaches and in
many situations outperforms them. Finally we evaluated the ability of the Parzen OCC
approach to predict new potential PPI targets, and validated these results by searching for
biological evidence in the literature
One-Class Classification: Taxonomy of Study and Review of Techniques
One-class classification (OCC) algorithms aim to build classification models
when the negative class is either absent, poorly sampled or not well defined.
This unique situation constrains the learning of efficient classifiers by
defining class boundary just with the knowledge of positive class. The OCC
problem has been considered and applied under many research themes, such as
outlier/novelty detection and concept learning. In this paper we present a
unified view of the general problem of OCC by presenting a taxonomy of study
for OCC problems, which is based on the availability of training data,
algorithms used and the application domains applied. We further delve into each
of the categories of the proposed taxonomy and present a comprehensive
literature review of the OCC algorithms, techniques and methodologies with a
focus on their significance, limitations and applications. We conclude our
paper by discussing some open research problems in the field of OCC and present
our vision for future research.Comment: 24 pages + 11 pages of references, 8 figure
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