Quantifying the spatio-temporal temperature dynamics of Greater London using thermal Earth observation

PhD ThesisUrban areas are highly sensitive to extreme events such as heatwaves. In order to understand how cities will respond to thermal stress it is critical to quantify not only their temporal temperature dynamics but also their spatial temperature variability. However, many cities lack weather station networks with a sufficient spatial distribution to characterise spatio-temporal intraurban temperature dynamics. One means by which spatially complete measurements of urban temperature may be derived is to employ satellite thermal Earth observed data. While some success has been achieved in understanding the temperature characteristics of cities using such data, relatively little work has been undertaken on establishing the use of long time-series Earth observed data as a supplement or alternative to screen-level air temperatures frequently utilised in urban climatological studies. In this thesis a software framework, centred around the use of a spatial database, is developed which can be used to gain an improved understanding of how satellite thermal Earth observed data can be used in the long timeseries analysis of urban temperature dynamics. The utility of the system is demonstrated by processing a 23 year time series (1985-2008) of 1,141 Advanced Very High Resolution Radiometer (AVHRR) images and hourly United Kingdom (UK) Met Office weather station measurements for the Greater London area. London was selected as the region of interest as it is the UK’s only megacity, and has been shown to exhibit both a significant urban heat island and a severe increase in population mortality during previous heatwave events. The software framework was employed to conduct two inter-related sets of analysis. First, the relationship over time between AVHRR estimated surface temperature (EST) and screen-level air temperature records is investigated and quantified. The resulting relationships are then used to produce an empirical model that can predict spatially complete summer-season air temperi atures for London. Cross-validation testing of the model at selected London weather stations showed model root mean square error (RMSE) ranging from 2.70 to 2.94°C and absolute errors in air temperature estimation of 0.45 to 1.67°C. A key finding of the thesis is that the minimal variation in prediction error between the different stations indicate a level of spatial robustness in the model across the urban surface, that is within the limits of the AVHRR EST precision. In addition, the model was used to estimate spatially averaged air temperatures over the Greater London area for selected summers, and showed a maximum error in air temperature prediction of 1.44°C. Furthermore, the prediction error for the heatwave summer of 2003 was 0.51°C, suggesting that such a model can successfully be used to estimate air temperatures for extreme heatwave summers. Such predictions are directly relevant to future assessments of urban population exposure to heatwaves, and it is envisaged that they could be used in conjunction with a population vulnerability index to create a spatially complete heatwave risk map for London. This work is then extended to investigate the utility of satellite estimated surface temperature measurements to characterise temporally and spatially intra-urban heatwave dynamics using the commonly employed urban heat island intensity metric (UHII). Analysis of the AVHRR EST found that the data are highly sensitive to local meteorological conditions, and that temporal aggregation at the monthly scale is required to provide robust data-sets for inter-year analysis of summer temperatures and generation of the UHII metric. Statistical testing of EST and air-temperature derived UHII for the heatwave summer of 2003 against other non-heatwave summers showed no significant increase in intensity at the 95% confidence level. This raises questions as to the applicability of the UHII metric to capture increases in urban temperatures during a heatwave event.Engineering and Physical Sciences Research Council and the School of Civil Engineering and Geoscience

VLSI design of configurable low-power coarse-grained array architecture

Biomedical signal acquisition from in- or on-body sensors often requires local (on-node) low-level pre-processing before the data are sent to a remote node for aggregation and further processing. Local processing is required for many different operations, which include signal cleanup (noise removal), sensor calibration, event detection and data compression. In this environment, processing is subject to aggressive energy consumption restrictions, while often operating under real-time requirements. These conflicting requirements impose the use of dedicated circuits addressing a very specific task or the use of domain-specific customization to obtain significant gains in power efficiency. However, economic and time-to-market constraints often make the development or use of application-specific platforms very risky.One way to address these challenges is to develop a sensor node with a general-purpose architecture combining a low-power, low-performance general microprocessor or micro-controller with a coarse-grained reconfigurable array (CGRA) acting as an accelerator. A CGRA consists of a fixed number of processing units (e.g., ALUs) whose function and interconnections are determined by some configuration data.The objective of this work is to create an RTL-level description of a low-power CGRA of ALUs and produce a low-power VLSI (standard cell) implementation, that supports power-saving features.The CGRA implementation should use as few resources as possible and fully exploit the intended operation environment. The design will be evaluated with a set of simple signal processing task

Pathway to the Square Kilometre Array - The German White Paper -

The Square Kilometre Array (SKA) is the most ambitious radio telescope ever planned. With a collecting area of about a square kilometre, the SKA will be far superior in sensitivity and observing speed to all current radio facilities. The scientific capability promised by the SKA and its technological challenges provide an ideal base for interdisciplinary research, technology transfer, and collaboration between universities, research centres and industry. The SKA in the radio regime and the European Extreme Large Telescope (E-ELT) in the optical band are on the roadmap of the European Strategy Forum for Research Infrastructures (ESFRI) and have been recognised as the essential facilities for European research in astronomy. This "White Paper" outlines the German science and R&D interests in the SKA project and will provide the basis for future funding applications to secure German involvement in the Square Kilometre Array.Comment: Editors: H. R. Kl\"ockner, M. Kramer, H. Falcke, D.J. Schwarz, A. Eckart, G. Kauffmann, A. Zensus; 150 pages (low resolution- and colour-scale images), published in July 2012, language English (including a foreword and an executive summary in German), the original file is available via the MPIfR homepag

Intercellular network structure and regulatory motifs in the human hematopoietic system.

The hematopoietic system is a distributed tissue that consists of functionally distinct cell types continuously produced through hematopoietic stem cell (HSC) differentiation. Combining genomic and phenotypic data with high-content experiments, we have built a directional cell-cell communication network between 12 cell types isolated from human umbilical cord blood. Network structure analysis revealed that ligand production is cell type dependent, whereas ligand binding is promiscuous. Consequently, additional control strategies such as cell frequency modulation and compartmentalization were needed to achieve specificity in HSC fate regulation. Incorporating the in vitro effects (quiescence, self-renewal, proliferation, or differentiation) of 27 HSC binding ligands into the topology of the cell-cell communication network allowed coding of cell type-dependent feedback regulation of HSC fate. Pathway enrichment analysis identified intracellular regulatory motifs enriched in these cell type- and ligand-coupled responses. This study uncovers cellular mechanisms of hematopoietic cell feedback in HSC fate regulation, provides insight into the design principles of the human hematopoietic system, and serves as a foundation for the analysis of intercellular regulation in multicellular systems

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is the most common type of leukemia. The Cancer Genome Atlas Research Network has demonstrated the increasing genomic complexity of acute myeloid leukemia (AML). In addition, the network has facilitated our understanding of the molecular events leading to this deadly form of malignancy for which the prognosis has not improved over past decades. AML is a highly heterogeneous disease, and cytogenetics and molecular analysis of the various chromosome aberrations including deletions, duplications, aneuploidy, balanced reciprocal translocations and fusion of transcription factor genes and tyrosine kinases has led to better understanding and identification of subgroups of AML with different prognoses. Furthermore, molecular classification based on mRNA expression profiling has facilitated identification of novel subclasses and defined high-, poor-risk AML based on specific molecular signatures. However, despite increased understanding of AML genetics, the outcome for AML patients whose number is likely to rise as the population ages, has not changed significantly. Until it does, further investigation of the genomic complexity of the disease and advances in drug development are needed. In this review, leading AML clinicians and research investigators provide an up-to-date understanding of the molecular biology of the disease addressing advances in diagnosis, classification, prognostication and therapeutic strategies that may have significant promise and impact on overall patient survival

The ALICE TPC, a large 3-dimensional tracking device with fast readout for ultra-high multiplicity events

The design, construction, and commissioning of the ALICE Time-Projection Chamber (TPC) is described. It is the main device for pattern recognition, tracking, and identification of charged particles in the ALICE experiment at the CERN LHC. The TPC is cylindrical in shape with a volume close to 90 m^3 and is operated in a 0.5 T solenoidal magnetic field parallel to its axis. In this paper we describe in detail the design considerations for this detector for operation in the extreme multiplicity environment of central Pb--Pb collisions at LHC energy. The implementation of the resulting requirements into hardware (field cage, read-out chambers, electronics), infrastructure (gas and cooling system, laser-calibration system), and software led to many technical innovations which are described along with a presentation of all the major components of the detector, as currently realized. We also report on the performance achieved after completion of the first round of stand-alone calibration runs and demonstrate results close to those specified in the TPC Technical Design Report.Comment: 55 pages, 82 figure

The High-Altitude Water Cherenkov (HAWC) Observatory in M\'exico: The Primary Detector

The High-Altitude Water Cherenkov (HAWC) observatory is a second-generation continuously operated, wide field-of-view, TeV gamma-ray observatory. The HAWC observatory and its analysis techniques build on experience of the Milagro experiment in using ground-based water Cherenkov detectors for gamma-ray astronomy. HAWC is located on the Sierra Negra volcano in M\'exico at an elevation of 4100 meters above sea level. The completed HAWC observatory principal detector (HAWC) consists of 300 closely spaced water Cherenkov detectors, each equipped with four photomultiplier tubes to provide timing and charge information to reconstruct the extensive air shower energy and arrival direction. The HAWC observatory has been optimized to observe transient and steady emission from sources of gamma rays within an energy range from several hundred GeV to several hundred TeV. However, most of the air showers detected are initiated by cosmic rays, allowing studies of cosmic rays also to be performed. This paper describes the characteristics of the HAWC main array and its hardware.Comment: Accepted for publications in Nuclear Inst. and Methods in Physics Research, A (2023) 168253 ( https://www.sciencedirect.com/science/article/abs/pii/S0168900223002437 ); 39 pages, 14 Figure

R&D Paths of Pixel Detectors for Vertex Tracking and Radiation Imaging

This report reviews current trends in the R&D of semiconductor pixellated sensors for vertex tracking and radiation imaging. It identifies requirements of future HEP experiments at colliders, needed technological breakthroughs and highlights the relation to radiation detection and imaging applications in other fields of science.Comment: 17 pages, 2 figures, submitted to the European Strategy Preparatory Grou

Satellite power system: Concept development and evaluation program. Volume 3: Power transmission and reception. Technical summary and assessment

Efforts in the DOE/NASA concept development and evaluation program are discussed for the solar power satellite power transmission and reception system. A technical summary is provided together with a summary of system assessment activities. System options and system definition drivers are described. Major system assessment activities were in support of the reference system definition, solid state system studies, critical technology supporting investigations, and various system and subsystem tradeoffs. These activities are described together with reference system updates and alternative concepts for each of the subsystem areas. Conclusions reached as a result of the numerous analytical and experimental evaluations are presented. Remaining issues for a possible follow-on program are identified