3,948 research outputs found
Southern Adventist University Undergraduate Catalog 2023-2024
Southern Adventist University\u27s undergraduate catalog for the academic year 2023-2024.https://knowledge.e.southern.edu/undergrad_catalog/1123/thumbnail.jp
Clinical practice guidelines for the diagnosis and management of Duchenne muscular dystrophy: a scoping review
IntroductionOur objective was to identify recent CPGs for the diagnosis and management of DMD and summarize their characteristics and reliability.MethodsWe conducted a scoping review of CPGs using MEDLINE, the Turning Research Into Practice (TRIP) database, Google Scholar, guidelines created by organizations, and other repositories to identify CPGs published in the last 5 years. Our protocol was drafted using the Preferred Reporting Items for Systematic Reviews and Meta-analyses for scoping reviews. To assess the reliability of the CPGs, we used all the domains included in the Appraisal of Guidelines Research and Evaluation II.ResultsWe selected three CPGs published or updated between 2015 and 2020. All the guidelines showed good or adequate methodological rigor but presented pitfalls in stakeholder involvement and applicability domains. Recommendations were coherent across CPGs on steroid treatment, except for minor differences in dosing regimens. However, the recommendations were different for new drugs.DiscussionThere is a need for current and reliable CPGs that develop broad topics on the management of DMD and consider the challenges of developing recommendations for RDs
Digitalization and Development
This book examines the diffusion of digitalization and Industry 4.0 technologies in Malaysia by focusing on the ecosystem critical for its expansion. The chapters examine the digital proliferation in major sectors of agriculture, manufacturing, e-commerce and services, as well as the intermediary organizations essential for the orderly performance of socioeconomic agents.
The book incisively reviews policy instruments critical for the effective and orderly development of the embedding organizations, and the regulatory framework needed to quicken the appropriation of socioeconomic synergies from digitalization and Industry 4.0 technologies. It highlights the importance of collaboration between government, academic and industry partners, as well as makes key recommendations on how to encourage adoption of IR4.0 technologies in the short- and long-term.
This book bridges the concepts and applications of digitalization and Industry 4.0 and will be a must-read for policy makers seeking to quicken the adoption of its technologies
Effects of municipal smoke-free ordinances on secondhand smoke exposure in the Republic of Korea
ObjectiveTo reduce premature deaths due to secondhand smoke (SHS) exposure among non-smokers, the Republic of Korea (ROK) adopted changes to the National Health Promotion Act, which allowed local governments to enact municipal ordinances to strengthen their authority to designate smoke-free areas and levy penalty fines. In this study, we examined national trends in SHS exposure after the introduction of these municipal ordinances at the city level in 2010.MethodsWe used interrupted time series analysis to assess whether the trends of SHS exposure in the workplace and at home, and the primary cigarette smoking rate changed following the policy adjustment in the national legislation in ROK. Population-standardized data for selected variables were retrieved from a nationally representative survey dataset and used to study the policy action’s effectiveness.ResultsFollowing the change in the legislation, SHS exposure in the workplace reversed course from an increasing (18% per year) trend prior to the introduction of these smoke-free ordinances to a decreasing (−10% per year) trend after adoption and enforcement of these laws (β2 = 0.18, p-value = 0.07; β3 = −0.10, p-value = 0.02). SHS exposure at home (β2 = 0.10, p-value = 0.09; β3 = −0.03, p-value = 0.14) and the primary cigarette smoking rate (β2 = 0.03, p-value = 0.10; β3 = 0.008, p-value = 0.15) showed no significant changes in the sampled period. Although analyses stratified by sex showed that the allowance of municipal ordinances resulted in reduced SHS exposure in the workplace for both males and females, they did not affect the primary cigarette smoking rate as much, especially among females.ConclusionStrengthening the role of local governments by giving them the authority to enact and enforce penalties on SHS exposure violation helped ROK to reduce SHS exposure in the workplace. However, smoking behaviors and related activities seemed to shift to less restrictive areas such as on the streets and in apartment hallways, negating some of the effects due to these ordinances. Future studies should investigate how smoke-free policies beyond public places can further reduce the SHS exposure in ROK
Southern Adventist University Undergraduate Catalog 2022-2023
Southern Adventist University\u27s undergraduate catalog for the academic year 2022-2023.https://knowledge.e.southern.edu/undergrad_catalog/1121/thumbnail.jp
Assessing cybersecurity at an industrial unit 4.0
Mestrado em Cibersegurança na Escola Superior de Tecnologia e Gestão do Instituto Politécnico de Viana do CasteloThe last 20 years have emerged significant developments in industrial production and development, with new technologies, networks and emerging production systems due to the development of the internet and new distributed adaptive production systems. These architectures resulted in improved service activities, new business models and increased demand and offering of goods, resulting in fewer interactions among production system participants. The convergence of IT/OT environments has increased the complexity and vulnerability of previously isolated OT/ICS networks, and the growing need to expand automation in the industry creates a big challenge in terms of cybersecurity. In this context, how can we identify suspicious activity, assess risks and help prevent downtime in an increasingly
technological industry? For this thesis, data collected through an online survey on the subject of convergence in the national industry was analyzed in order to know if this subject, from the perspective
of professionals, deserves the attention of the organizations where they develop their professional activity with technologies of IT/OT. A set of real cases and the consequences of serious security failures that occurred in the period between 2021 and 2023, increasingly common, with an impact on the global industry, are identified and analyzed. The technological complexity that results from the convergence between information technology (IT) and Operational Technology (OT) is analyzed, highlighting in practice the challenges for which cybersecurity has to prepare itself in order to develop effective and
context-adjusted responses under review. The biggest challenge lies in the cyber-secure integration of data-centric computing technologies in the IT systems with the monitoring of events, processes and devices in the OT systems. After analyzing the complexity of the IT/OT technologies essential for Industry 4.0, we recommend a careful reading of the set of frameworks described in this document about internationally recognized good practices in cybersecurity. Regular access to public databases, described in this document, on risk patterns and fundamental vulnerabilities is recommended for the development of an updated cybersecurity strategy. Finally, good practices are described to analyze, frame and apply to avoid risk situations by monitoring the trend of cybersecurity incidents, known software flaws, as well as vulnerabilities and associated risks, which can result in ransomware and its associated consequences.Nos últimos 20 anos surgiram desenvolvimentos significativos na produção e desenvolvimento
industrial, com novas tecnologias, redes e sistemas de produção emergentes devido ao desenvolvimento da internet e novos sistemas de produção adaptativos distribuídos. Essas arquiteturas resultaram em melhores atividades de serviço, novos modelos de negócios e aumento da demanda e oferta de bens, resultando em menos interações entre os participantes do sistema de produção.
A convergência de ambientes de IT/OT aumentou a complexidade e vulnerabilidade de redes OT/ICS anteriormente isoladas, e a crescente necessidade de expandir a automação na indústria cria um grande desafio em termos de segurança cibernética. Nesse contexto, como identificar atividades suspeitas, avaliar riscos e ajudar a prevenir paradas em um setor cada vez mais tecnológico? Para esta tese, foram analisados dados recolhidos através de um inquérito online sobre o tema da convergência na indústria nacional, de forma a saber se este tema, na perspetiva dos profissionais, merece a atenção das organizações onde desenvolvem a sua atividade profissional com tecnologias de IT/OT. São identificados e analisados um conjunto de casos reais e as consequências de falhas graves de segurança ocorridas no período entre 2021 e 2023, cada vez mais comuns, com impacto na indústria à escala global. Analisa-se a complexidade tecnológica que resulta da convergência entre tecnologias de
informação (IT) e tecnologias operacionais (OT), destacando na prática os desafios para os quais a cibersegurança tem de se preparar de forma a desenvolver respostas eficazes e ajustadas ao contexto em análise. O maior desafio está na integração ”cibersegura” de tecnologias de computação centradas em dados nos sistemas de IT com a monitorização de eventos, de processos e de dispositivos nos sistemas OT. Depois de analisar a complexidade das tecnologias IT/OT essenciais para a Indústria 4.0, recomenda-se uma leitura atenta do conjunto de frameworks descritos neste documento sobre boas práticas internacionalmente reconhecidas em cibersegurança. Bem como do acesso regular às bases de dados públicas, descritas neste documento, sobre padrões de risco e vulnerabilidades fundamentais essenciais para o desenvolvimento de uma estratégia de cibersegurança atualizada. Por fim, são sugeridas, um conjunto de boas práticas para analisar, enquadrar, e aplicar na estratégia de cibersegurança de uma organização, para evitar situações de risco, monitorizando a tendência de incidentes de cibersegurança, de falhas de software conhecidas, de vulnerabilidades e riscos associados, que podem resultar, por exemplo, em ransomware com as suas consequências associadas
Proc. 33. Workshop Computational Intelligence, Berlin, 23.-24.11.2023
Dieser Tagungsband enthält die Beiträge des 33. Workshops „Computational Intelligence“ der vom 23.11. – 24.11.2023 in Berlin stattfindet. Die Schwerpunkte sind Methoden, Anwendungen und Tools für ° Fuzzy-Systeme, ° Künstliche Neuronale Netze, ° Evolutionäre Algorithmen und ° Data-Mining-Verfahren sowie der Methodenvergleich anhand von industriellen und Benchmark-Problemen.The workshop proceedings contain the contributions of the 33rd workshop "Computational Intelligence" which will take place from 23.11. - 24.11.2023 in Berlin. The focus is on methods, applications and tools for ° Fuzzy systems, ° Artificial Neural Networks, ° Evolutionary algorithms and ° Data mining methods as well as the comparison of methods on the basis of industrial and benchmark problems
A data-driven approach for a project management methodology for R&D Projects.
267 p.The thesis is based on the proposal of an R&D project management methodology based on the Earned Quality Method (EQM) and data analysis to improve the efficiency of R&D projects in a near-real production environment in a TRL 5 to 7. The thesis relies upon published papers that propose measuring and improving the management of R&D projects. The methodology leans on the formulation and gradual and recurrent evaluation of quality criteria as a performance indicator of the work carried out. The thesis stands on the concept that quality is a measurable quantity that accumulates throughout the project. The proposed project management methodology is built on three main aspects: Collaboration between the University and Industry; The correct interpretation of the TRL where research projects are developed; The study of different metrics for project management, such as the measurement of the success of projects, the KPIs of a project-based organisation, and the EQM. The methodology has been tested with three actual use cases with different characteristics in terms of project size, funding and team members; and validated on an R&D Centre in Advanced Manufacturing in Aeronautics. The pillars of the thesis are focused on the analysis of the mentioned components and their integration for the development of a methodology to improve the efficiency in the use of resources and the quality of obtained results in the R&D projects' framework. The key findings of these studies demonstrate the effectiveness of using quality criteria for measuring progress in the management of R&D projects, as well as providing a better understanding of several critical aspects of the realisation of these projects
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