Enabling Layered Video Coding for IMS-Based IPTV Home Services

Nowadays IPTV services are gaining attention from both providers and end users. There is a large effort toward the integration of these services into emerging next-generation network architectures. In particular, one of the most relevant solutions is being proposed by ETSI-TISPAN and is based on the IP multimedia subsystem. This article focuses on introducing layered video coding into TISPAN IMS-based IPTV architecture, allowing cost-effective efficient solutions both for residential users and providers (e.g., flexible support of heterogeneous devices, live mosaics, adaptive video quality based on device and/or network capabilities). The advantages of using layered video coding in the TISPAN IPTV solution are analyzed and illustrated with a set of use cases. Furthermore, this solution has been integrated into a multimedia testbed in order to validate the presented proposal

User generated content for IMS-based IPTV

Includes abstract.Includes bibliographical references.Web 2.0 services have been on the rise due to improved bandwidth availability. Users can now connect to the internet with a variety of portable devices which are capable of performing multiple tasks. Due to this, services such as Voice over IP (VoIP), presence, social networks, instant messaging (IM) and Internet Protocol television (IPTV) to mention but a few, started to emerge...This thesis proposed a framework that will offer user-generated content on an IMS-Based IPTV and the framework will include a personalised advertising system..

TV-Centric technologies to provide remote areas with two-way satellite broadband access

October 1-2, 2007, Rome, Italy TV-Centric Technologies To Provide Remote Areas With Two-Way Satellite Broadband Acces

A two-way interactive broadband satellite architecture to break the digital divide barrier

September 24-26, 2007, Turin, Ital

The architecture of the High Performance Storage System (HPSS)

The rapid growth in the size of datasets has caused a serious imbalance in I/O and storage system performance and functionality relative to application requirements and the capabilities of other system components. The High Performance Storage System (HPSS) is a scalable, next-generation storage system that will meet the functionality and performance requirements or large-scale scientific and commercial computing environments. Our goal is to improve the performance and capacity of storage by two orders of magnitude or more over what is available in the general or mass marketplace today. We are also providing corresponding improvements in architecture and functionality. This paper describes the architecture and functionality of HPSS

Ontwerp en evaluatie van content distributie netwerken voor multimediale streaming diensten.

Traditionele Internetgebaseerde diensten voor het verspreiden van bestanden, zoals Web browsen en het versturen van e-mails, worden aangeboden via één centrale server. Meer recente netwerkdiensten zoals interactieve digitale televisie of video-op-aanvraag vereisen echter hoge kwaliteitsgaranties (QoS), zoals een lage en constante netwerkvertraging, en verbruiken een aanzienlijke hoeveelheid bandbreedte op het netwerk. Architecturen met één centrale server kunnen deze garanties moeilijk bieden en voldoen daarom niet meer aan de hoge eisen van de volgende generatie multimediatoepassingen. In dit onderzoek worden daarom nieuwe netwerkarchitecturen bestudeerd, die een dergelijke dienstkwaliteit kunnen ondersteunen. Zowel peer-to-peer mechanismes, zoals bij het uitwisselen van muziekbestanden tussen eindgebruikers, als servergebaseerde oplossingen, zoals gedistribueerde caches en content distributie netwerken (CDN's), komen aan bod. Afhankelijk van de bestudeerde dienst en de gebruikte netwerktechnologieën en -architectuur, worden gecentraliseerde algoritmen voor netwerkontwerp voorgesteld. Deze algoritmen optimaliseren de plaatsing van de servers of netwerkcaches en bepalen de nodige capaciteit van de servers en netwerklinks. De dynamische plaatsing van de aangeboden bestanden in de verschillende netwerkelementen wordt aangepast aan de heersende staat van het netwerk en aan de variërende aanvraagpatronen van de eindgebruikers. Serverselectie, herroutering van aanvragen en het verspreiden van de belasting over het hele netwerk komen hierbij ook aan bod

TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment

Background Patients with cancer benefit from treatment with immune checkpoint inhibitors (ICIs), and those with an inflamed tumor microenvironment (TME) and/or high tumor mutation burden (TMB), particularly, tend to respond to ICIs; however, some patients fail, whereas others acquire resistance after initial response despite the inflamed TME and/or high TMB. We assessed the detailed biological mechanisms of resistance to ICIs such as programmed death 1 and/or cytotoxic T-lymphocyte-associated protein 4 blockade therapies using clinical samples. Methods We established four pairs of autologous tumor cell lines and tumor-infiltrating lymphocytes (TILs) from patients with melanoma treated with ICIs. These tumor cell lines and TILs were subjected to comprehensive analyses and in vitro functional assays. We assessed tumor volume and TILs in vivo mouse models to validate identified mechanism. Furthermore, we analyzed additional clinical samples from another large melanoma cohort. Results Two patients were super-responders, and the others acquired resistance: the first patient had a non-inflamed TME and acquired resistance due to the loss of the beta-2 microglobulin gene, and the other acquired resistance despite having inflamed TME and extremely high TMB which are reportedly predictive biomarkers. Tumor cell line and paired TIL analyses showed high CD155, TIGIT ligand, and TIGIT expression in the tumor cell line and tumor-infiltrating T cells, respectively. TIGIT blockade or CD155-deletion activated T cells in a functional assay using an autologous cell line and paired TILs from this patient. CD155 expression increased in surviving tumor cells after coculturing with TILs from a responder, which suppressed TIGIT+ T-cell activation. Consistently, TIGIT blockade or CD155-deletion could aid in overcoming resistance to ICIs in vivo mouse models. In clinical samples, CD155 was related to resistance to ICIs in patients with melanoma with an inflamed TME, including both primary and acquired resistance. Conclusions The TIGIT/CD155 axis mediates resistance to ICIs in patients with melanoma with an inflamed TME, promoting the development of TIGIT blockade therapies in such patients with cancer