123,400 research outputs found

    Smart PIN: utility-based replication and delivery of multimedia content to mobile users in wireless networks

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    Next generation wireless networks rely on heterogeneous connectivity technologies to support various rich media services such as personal information storage, file sharing and multimedia streaming. Due to users’ mobility and dynamic characteristics of wireless networks, data availability in collaborating devices is a critical issue. In this context Smart PIN was proposed as a personal information network which focuses on performance of delivery and cost efficiency. Smart PIN uses a novel data replication scheme based on individual and overall system utility to best balance the requirements for static data and multimedia content delivery with variable device availability due to user mobility. Simulations show improved results in comparison with other general purpose data replication schemes in terms of data availability

    Analysis of Interphase Chromatin Motion in HeLa Cells

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    Motion of particles under influencing forces may be observed under light microscopy techniques. Variations in mobility of particles may give relevant biophysical information. Automated high resolution single particle tracking techniques were used to characterize interphase chromatin mobility in the cell nucleus. Interphase chromatin undergo replication prior to cell division with the assistance of replication proteins (machinery) which modify chromatin mobility. Using dual color imaging of flourescently tagged chromatin and proliferating cell nuclear antigen (PCNA) were followed through interphase. Chromatin motion was modelled as a two dimensional random walk. Reduction in chromatin mobility was observed during S phase was dependent on proximity to the replication machinery. Mobility during G1 and G2 phase is independent of proximity to GFP-PCNA maxima and is higher than during S phase. These results suggest that replication selectively inhibits chromatin mobility. Local proximity to replication machinery however, cannot account for the entire mobility difference. By modelling the mean square displacement as a power law, sub-diffusive behavior was observed in S phase chromatin whereas non S phase exhibited normal diffusional characteristics

    Geography of Scientific Knowledge: A Proximity Approach

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    The geography of scientific knowledge is defined as the replication process of locally produced knowledge claims. Proximity in social, cognitive, and physical dimensions promotes the sharing of tacit knowledge. Thus, given the complementarity between tacit and codified knowledge, proximity supports the replication of codified knowledge claims. Distinguishing between controversial and uncontroversial contexts, one can understand the sociology of science as explaining the behaviour of scientists from their proximity to other scientists, and the sociology of scientific knowledge as describing the processes that constitute the proximity between scientists.replication, knowledge claim, proximity, mobility, controversy, incentives, sociology of science, economics of science, geography of science, sociology of scientific knowledge

    D4.3 Catalogue of mobility best practices

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    RECIPROCITY aims to transform European cities into climate-resilient and connected, multimodal nodes for smart and clean mobility. The project's innovative four-stage replication approach is designed to showcase and disseminate best practices for sustainable urban development and mobility. As part of this project, this catalogue of mobility provides guidance and direction for mobility services providers and cities looking to implement sustainable mobility solutions. It is based on interviews and results from RECIPROCITY workshops and webinars and is designed to help cities across Europe become more resilient, connected, and sustainable. The catalogue of best practices is a critical component of the project's four-stage replication approach. It includes a range of strategies and tools for sustainable urban development and mobility, such as innovative transport modes, smart mobility solutions, and sustainable infrastructure. The catalogue also provides guidance on how to implement these best practices and adapt them to local contexts, ensuring they are feasible and cost-effective

    PCNA appears in two populations of slow and fast diffusion with a constant ratio throughout S-phase in replicating mammalian cells

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    DNA replication is a fundamental cellular process that precedes cell division. Proliferating cell nuclear antigen (PCNA) is a central scaffold protein that orchestrates DNA replication by recruiting many factors essential for the replication machinery. We studied the mobility of PCNA in live mammalian cells using single-particle tracking in combination with photoactivated-localization microscopy (sptPALM) and found two populations. The first population which is only present in cells with active DNA replication, showed slow diffusion and was found to be located in replication foci. The second population showed fast diffusion, and represents the nucleoplasmic pool of unbound PCNA not involved in DNA replication. The ratio of these two populations remained constant throughout different stages of S-phase. A fraction of molecules in both populations showed spatially constrained mobility. We determined an exploration radius of ~100 nm for 13% of the slow-diffusing PCNA molecules, and of ~600 nm for 46% of the fast-diffusing PCNA molecules

    D3.3 Business models report

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    RECIPROCITY aims to transform European cities into climate-resilient and connected, multimodal nodes for smart and clean mobility. The project's innovative four-stage replication approach is designed to showcase and disseminate best practices for sustainable urban development and mobility. As part of this project, the present business model report (D3.3) provides an overview of innovative urban mobility business models that could be tailored to cities in the RECIPROCITY replication ecosystem. The work developed was based upon the work carried-out in WP1-2-4, and aimed to collect and derive the business model patterns for urban mobility and propose a business model portfolio that encourage cross-sector collaboration and create an integrated mobility system. This report is therefore addressed to cities and local authorities that have to meet mobility challenges (i.e. high costs and low margin, broad set of partners, competing with private car) by providing new services to activate and accelerate a sustainable modal shift. It also targets other stakeholders interested in business model concepts applied to cities

    The Surprising Success of a Replication That Failed

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    In a recent paper (jasss.soc.surrey.ac.uk/12/4/11.html), Oliver Will contends that the effect of mobility on trust that we originally reported (2002) depends on \'an assumption that is most probably an unwilling, unintended, and unwanted implication of the code.\' When we experimented with Will\'s revised model, we came to the opposite conclusion: his version provides stronger support for our theory than does our original. The explanation is that Will left the learning rate at the upper limit of 1.0, the level we assumed in our original paper. When we lowered the learning rate to compensate for the removal of the contested assumption, the results showed how mobility can lead to an increase in trust, which is consistent with our explanation for higher trust in the US compared to Japan. Moreover, the model also shows that it is possible for there to be too much mobility.Trust, Mobility, Replication

    Service migration versus service replication in Multi-access Edge Computing

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    Envisioned low-latency services in 5G, like automated driving, will rely mainly on Multi-access Edge Computing (MEC) to reduce the distance, and hence latency, between users and the remote applications. MEC hosts will be deployed close to mobile base stations, constituting a highly distributed computing platform. However, user mobility may raise the need to migrate a MEC application among MEC hosts to ensure always connecting users to the optimal server, in terms of geographical proximity, Quality of Service (QoS), etc. However, service migration may introduce: (i) latency for users due to the downtime duration; (ii) cost for the network operator as it consumes bandwidth to migrate services. One solution could be the use of service replication, which pro-actively replicates the service to avoid service migration and ensure low latency access. Service replication induces cost in terms of storage, though, requiring a careful study on the number of service to replicate and distribute in MEC. In this paper, we propose to compare service migration and service replication via an analytical model. The proposed model captures the relation between user mobility and service duration on service replication as well as service migration costs. The obtained results allow to propose recommendations between using service migration or service replication according to user mobility and the number of replicates to use for two types of service.This work was partially funded by the European Union’s Horizon 2020 research and innovation program under the 5GTransformer project (grant no. 761536
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