Detecting the Presence of Disease by Unifying Two Methods of Remote Sensing.

There is currently no effective tool available to quickly and economically measure a change in landmass in the setting of biomedical professionals and environmental specialists. The purpose of this study is to structure and demonstrate a statistical change-detection method using remotely sensed data that can detect the presence of an infectious land borne disease. Data sources included the Texas Department of Health database, which provided the types of infectious land borne diseases and indicated the geographical area to study. Methods of data collection included the gathering of images produced by digital orthophoto quadrangle and aerial videography and Landsat. Also, a method was developed to identify statistically the severity of changes of the landmass over a three-year period. Data analysis included using a unique statistical detection procedure to measure the severity of change in landmass when a disease was not present and when the disease was present. The statistical detection method was applied to two different remotely sensed platform types and again to two like remotely sensed platform types. The results indicated that when the statistical change detection method was used for two different types of remote sensing mediums (i.e.-digital orthophoto quadrangle and aerial videography), the results were negative due to skewed and unreliable data. However, when two like remote sensing mediums were used (i.e.- videography to videography and Landsat to Landsat) the results were positive and the data were reliable

The Small Animals of Maasai Settlements: Ethnoarchaeological Investigations of the Commensalism Model

This research was designed to test Tchernov\u27s model of commensalism and the idea that remains of commensal species that today coexist with humans in settlement environments could be used to detect early sedentism in the archaeological record. The validity of the model has been questioned due to the lack of empirical knowledge on commensalism in a wide range of settlement environments including sedentary and more mobile ones. This study examined the commensalism model by focusing on seasonally occupied settlements of Maasai pastoralists in East Africa. Methods from ecology, ethnography, and archaeology were used to document the impact of Maasai settlements on associated communities of small rodents and shrews: micromammals), to measure the intensity of human occupation in settlements, and to relate settlement intensity to micromammalian communities. Taphonomic approaches were also used to evaluate the potential for accumulation and preservation of evidence on commensalism in the substrate of the settlements. The results of the study showed that, in contrast to what we might expect in highly sedentary settings, Maasai settlements increased rather than decreased the biological diversity of local micromammalian communities. Along a gradient of increasing duration of human occupation, but continued seasonal use of settlements, there was no manifest increase in the population of any single species that would amount to pronounced commensalism. This supports the commensalism/sedentism linkage but also suggests more broadly that it should be possible to demarcate distinct contexts of commensalism and related levels of biological diversity in relation to varying intensities of site occupation. These results call for greater investment in systematic fine-recovery and study of variability of micromammalian assemblages at archaeological excavations

Linking Welfare and Quality of Scientific Output in Cynomolgus Macaques (Macaca fascicularis) used for Regulatory Toxicology

Cynomolgus macaques (Macaca fascicularis) are the most commonly used non-human primate for research and testing in Europe. Their principal use is in preclinical safety testing of new pharmaceuticals to assess risk of adverse effects, as indicated by changes in a core battery of physiological measures before human exposure. Regulatory studies are strictly controlled through legislation and codes of practices underpinned by the principles of humane science, the 3Rs; Replacement, Reduction and Refinement. Despite the link between good welfare and good science now universally made in codes of practice, legislation and the literature, there are few studies aimed at systematically examining the link and almost no quantitative data from cynomolgus macaques used for toxicology. The main aim of this thesis was to examine the link between Refinement, animal welfare and scientific output for this important animal model, piggy-backing on regulatory studies conducted by a large contract research organisation. In the laboratory, animal welfare is formally considered in terms of Refinement which has evolved to include both the reduction of negative welfare states and the proactive enhancement of positive welfare over the animal’s lifetime. A multidisciplinary approach to welfare assessment including measures of behaviour, physiology and physical health, and which built upon current unit procedures was undertaken to produce an overall assessment of welfare in cynomolgus macaques. Macaque facial expressions, vocalisations, activity and position in the home cage, body weight change, body condition and alopecia scores were found to be reliable indicators of welfare state and would be most feasible for care staff to monitor. The concept of quality of scientific output was defined in relation to toxicological findings and includes sensitivity, reliability and repeatability of individual measures in the core battery (e.g. heart rate, blood pressure, haematology, clinical chemistry and organ weights). The link between welfare and quality of scientific output was then systematically explored with Refinements to macaque use in regulatory studies. The first, a data mining study, undertaken to quantify the effects on biological data recorded from cynomolgus macaques, used in regulatory studies over an eight-year period as the CASE sponsor transitioned from single to permanent group housing, found the effects to be highly variable on individual parameters in the core battery and in some instances welfare-positive effects of group housing were confounded by concurrent changes in standard operating procedures. A further study of planned Refinements to macaque-care staff interaction through enhanced socialisation was found to help animals cope better with husbandry and scientific procedures and enhance quality of cardiovascular measures recorded at baseline. In light of these findings a number of recommendations are made including a framework of terms useful for measuring quality of scientific output, a welfare assessment framework and Refinements to husbandry and scientific procedures for cynomolgus macaques used in regulatory toxicology. Because of their capacity to suffer it is both ethically and scientifically important that macaque welfare is maximised and their use results in valid and reliable experimental outcomes informing on the safety and efficacy of new pharmaceuticals prior to human exposure

Smart and Sustainable Planning for Cities and Regions

This open access book offers a selection of research papers and case studies presented at the 3rd international conference “Smart and Sustainable Planning for Cities and Regions”, held in December 2019 in Bolzano, Italy, and explores the concept of smart and sustainable planning, including top contributions from academics, policy makers, consultants and other professionals. Innovation processes such as co-design and co-creation help establish collaborations that engage with stakeholders in a trustworthy and transparent environment while answering the need for new value propositions. The importance of an integrated, holistic approach is widely recognized to break down silos in local government, in particular, when aimed at achieving a better integration of climate-energy planning. Despite the ongoing urbanization and polarization processes, new synergies between urban and rural areas emerge, linking development opportunities to intrinsic cultural, natural and man-made landscape values. The increasing availability of big, real-time urban data and advanced ICT facilitates frequent assessment and continuous monitoring of performances, while allowing fine-tuning as needed. This is valid not only for individual projects but also on a wider scale. In addition, and circling back to the first point, (big) urban data and ICT can be of enormous help in facilitating engagement and co-creation by raising awareness and by providing insight into the local consequences of specific plans. However, this potential is not yet fully exploited in standard processes and procedures, which can therefore lack the agility and flexibility to keep up with the pulse of the city and dynamics of society. The book provides a multi-disciplinary outlook based on experience to orient the reader in the giant galaxy of smart and sustainable planning, support the transposition of research into practice, scale up visionary approaches and design groundbreaking planning policies and tools