10,970 research outputs found

    Animating potential for intensities and becoming in writing: challenging discursively constructed structures and writing conventions in academia through the use of storying and other post qualitative inquiries

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    Written for everyone ever denied the opportunity of fulfilling their academic potential, this is ‘Chloe’s story’. Using composite selves, a phrase chosen to indicate multiplicities and movement, to story both the initial event leading to ‘Chloe’s’ immediate withdrawal from a Further Education college and an imaginary second chance to support her whilst at university, this Deleuzo-Guattarian (2015a) ‘assemblage’ of post qualitative inquiries offers challenge to discursively constructed structures and writing conventions in academia. Adopting a posthuman approach to theorising to shift attention towards affects and intensities always relationally in action in multiple ‘assemblages’, these inquiries aim to decentre individual ‘lecturer’ and ‘student’ identities. Illuminating movements and moments quivering with potential for change, then, hoping thereby to generate second chances for all, different approaches to writing are exemplified which trouble those academic constraints by fostering inquiry and speculation: moving away from ‘what is’ towards ‘what if’. With the formatting of this thesis itself also always troubling the rigid Deleuzo-Guattarian (2015a) ‘segmentary lines’ structuring orthodox academic practice, imbricated in these inquiries are attempts to exemplify Manning’s (2015; 2016) ‘artfulness’ through shifts in thinking within and around an emerging PhD thesis. As writing resists organising, the verb thesisising comes into play to describe the processes involved in creating this always-moving thesis. Using ‘landing sites’ (Arakawa and Gins, 2009) as a landscaping device, freely creating emerging ‘lines of flight’ (Deleuze and Guattari, 2015a) so often denied to students forced to adhere to strict academic conventions, this ‘movement-moving’ (Manning, 2014) opens up opportunities for change as in Manning’s (2016) ‘research-creation’. Arguing for a moving away from writing-representing towards writing-inquiring, towards a writing ‘that does’ (Wyatt and Gale, 2018: 127), and toward writing as immanent doing, it is hoped to animate potential for intensities and becoming in writing, offering opportunities and glimmerings of the not-yet-known

    The determinants of value addition: a crtitical analysis of global software engineering industry in Sri Lanka

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    It was evident through the literature that the perceived value delivery of the global software engineering industry is low due to various facts. Therefore, this research concerns global software product companies in Sri Lanka to explore the software engineering methods and practices in increasing the value addition. The overall aim of the study is to identify the key determinants for value addition in the global software engineering industry and critically evaluate the impact of them for the software product companies to help maximise the value addition to ultimately assure the sustainability of the industry. An exploratory research approach was used initially since findings would emerge while the study unfolds. Mixed method was employed as the literature itself was inadequate to investigate the problem effectively to formulate the research framework. Twenty-three face-to-face online interviews were conducted with the subject matter experts covering all the disciplines from the targeted organisations which was combined with the literature findings as well as the outcomes of the market research outcomes conducted by both government and nongovernment institutes. Data from the interviews were analysed using NVivo 12. The findings of the existing literature were verified through the exploratory study and the outcomes were used to formulate the questionnaire for the public survey. 371 responses were considered after cleansing the total responses received for the data analysis through SPSS 21 with alpha level 0.05. Internal consistency test was done before the descriptive analysis. After assuring the reliability of the dataset, the correlation test, multiple regression test and analysis of variance (ANOVA) test were carried out to fulfil the requirements of meeting the research objectives. Five determinants for value addition were identified along with the key themes for each area. They are staffing, delivery process, use of tools, governance, and technology infrastructure. The cross-functional and self-organised teams built around the value streams, employing a properly interconnected software delivery process with the right governance in the delivery pipelines, selection of tools and providing the right infrastructure increases the value delivery. Moreover, the constraints for value addition are poor interconnection in the internal processes, rigid functional hierarchies, inaccurate selections and uses of tools, inflexible team arrangements and inadequate focus for the technology infrastructure. The findings add to the existing body of knowledge on increasing the value addition by employing effective processes, practices and tools and the impacts of inaccurate applications the same in the global software engineering industry

    Omics measures of ageing and disease susceptibility

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    While genomics has been a major field of study for decades due to relatively inexpensive genotyping arrays, the recent advancement of technology has also allowed the measure and study of various “omics”. There are now numerous methods and platforms available that allow high throughput and high dimensional quantification of many types of biological molecules. Traditional genomics and transcriptomics are now joined by proteomics, metabolomics, glycomics, lipidomics and epigenomics. I was lucky to have access to a unique resource in the Orkney Complex Disease Study (ORCADES), a cohort of individuals from the Orkney Islands that are extremely deeply annotated. Approximately 1000 individuals in ORCADES have genomics, proteomics, lipidomics, glycomics, metabolomics, epigenomics, clinical risk factors and disease phenotypes, as well as body composition measurements from whole body scans. In addition to these cross-sectional omics and health related measures, these individuals also have linked electronic health records (EHR) available, allowing the assessment of the effect of these omics measures on incident disease over a ~10-year follow up period. In this thesis I use this phenotype rich resource to investigate the relationship between multiple types of omics measures and both ageing and health outcomes. First, I used the ORCADES data to construct measures of biological age (BA). The idea that there is an underlying rate at which the body deteriorates with age that varies between individuals of the same chronological age, this biological age, would be more indicative of health status, functional capacity and risk of age-related diseases than chronological age. Previous models estimating BA (ageing clocks) have predominantly been built using a single type of omics assay and comparison between different omics ageing clocks has been limited. I performed the most exhaustive comparison of different omics ageing clocks yet, with eleven clocks spanning nine different omics assays. I show that different omics clocks overlap in the information they provide about age, that some omics clocks track more generalised ageing while others track specific disease risk factors and that omics ageing clocks are prognostic of incident disease over and above chronological age. Second, I assessed whether individually or in multivariable models, omics measures are associated with health-related risk factors or prognostic of incident disease over 10 years post-assessment. I show that 2,686 single omics biomarkers are associated with 10 risk factors and 44 subsequent incident diseases. I also show that models built using multiple biomarkers from whole body scans, metabolomics, proteomics and clinical risk factors are prognostic of subsequent diabetes mellitus and that clinical risk factors are prognostic of incident hypertensive disorders, obesity, ischaemic heart disease and Framingham risk score. Third, I investigated the genetic architecture of a subset of the proteomics measures available in ORCADES, specifically 184 cardiovascular-related proteins. Combining genome-wide association (GWAS) summary statistics from ORCADES and 17 other cohorts from the SCALLOP Consortium, giving a maximum sample size of 26,494 individuals, I performed 184 genome-wide association meta-analyses (GWAMAs) on the levels of these proteins circulating in plasma. I discovered 592 independent significant loci associated with the levels of at least one protein. I found that between 8-37% of these significant loci colocalise with known expression quantitative trait loci (eQTL). I also find evidence of causal associations between 11 plasma protein levels and disease susceptibility using Mendelian randomisation, highlighting potential candidate drug targets

    AIUCD 2022 - Proceedings

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    L’undicesima edizione del Convegno Nazionale dell’AIUCD-Associazione di Informatica Umanistica ha per titolo Culture digitali. Intersezioni: filosofia, arti, media. Nel titolo ù presente, in maniera esplicita, la richiesta di una riflessione, metodologica e teorica, sull’interrelazione tra tecnologie digitali, scienze dell’informazione, discipline filosofiche, mondo delle arti e cultural studies

    Developing end-of-life care at a Portuguese nursing home through participatory action research

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    Background: Nursing homes are places where older people live and often die but little is known about the needs of those who care for them, in Portugal. Aim: to identify the needs of nursing home staff when caring for older people at the end of life; to understand the cultural nuances of providing care at the end-of-life in nursing homes; to develop, with nursing home staff, a culturally appropriate programme that meets their needs; and to plan for future development. Methods: Participatory Action Research was used to identify needs and to develop interventions, designed by the staff themselves, aimed at improving care. Up to ten nursing home staff participated in a six-cycle research process, with data collected, analysed, and used in sequential plan-act-reflect steps. Findings: The silence that surrounds a resident’s death has a severe impact on the lives of those who survive him/her. Lacking competencies in grief management, and with no emotional and relational space to express grief emotions, staff strive to manage their loss, while trying to support other residents. Acknowledging the existence of death and its impact on nursing home life made the invisibility of death and mourning visible, and interventions possible, providing closure to all. Conclusion: The impact of death and dying on nursing home life needs to be recognised. If adequately supported, nursing home staff can develop strategies to manage grief and mourning, to improve their knowledge of the residents’ needs and wishes, improve communication among staff, and ultimately improve care

    A Cross-cultural Comparative Study of Dark Triad and Five-Factor Personality Models in Relation to Prejudice and Aggression

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    When examining socially malevolent outcomes in the form of prejudice and aggression, previous research on the Dark Triad and five-factor personality models has failed to consider potential cross-cultural differences. A deeper understanding of cross-cultural variations is necessary because these factors represent important social problems and risks. Prior investigation has so far only established preliminary relationships between the Dark Triad and the Big Five model and these outlined associations influence prejudice and aggression. Accordingly, this thesis consisted of two phases. The first examined interrelationships between Dark Triad traits (psychopathy, narcissism, and Machiavellianism) and Big Five personality dimensions (extraversion, neuroticism, agreeableness, openness, conscientiousness) in UK and Russian samples. The second used the results from the initial phase to inform the baseline of a predictive model, which was extended. Both phases used cross-sectional designs, correlation-based methods of analysis (e.g., confirmatory factor analysis, structural equation modelling with mediation, path analysis and invariance analysis), and large samples, comprising a range of backgrounds and ages. The analysis identified the strongest and weakest relationships between personality traits and prejudice and aggression. This research made an original contribution to existing literature by identifying novel relationships

    The geographies of care and training in the development of assistance dog partnerships

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    Human-assistance-dog partnerships form a significant phenomena that have been overlooked in both animal geographies and disability geographies. By focusing on one Assistance Dogs UK (ADUK) charity, ‘Dog A.I.D’., a charity that helps physically disabled and chronically ill people to train their own pets to be assistance dogs, I detail the intimate entangled lifeworlds that humans and dogs occupy. In doing so, I also dialogue between the sub-disciplinary fields of animal geographies and disability geographies, by exploring two broad thematic areas – embodiment and care. As such, this thesis examines the geographies of assistance dog partnership, the care and training practices involved, the benefits and challenges of sharing a lifeworld with a different species, and the changing relationship from a human-pet bond to a human-assistance-dog partnership. Drawing on lived experience and representations of assistance dog partnerships gathered through qualitative (and quantitative) research methods, including a survey, semi-structured interviews (face-to-face, online, and telephone), video ethnography, and magazine analysis, I contribute to research on the assistance dog partnerships and growing debates around the more-than-human nature of care. The ethnomethodological approach to exploring how training occurs between disabled human and assistance dog is also noteworthy as it centres the lively experiences of practice at work between species. The thesis is organised around interconnected themes: the intimate worlds of assistance dog partnerships, working bodies, and caring relations. These thematics allow for a geographical interpretation into the governance, spatial organisation, and representations of dog assistance partnerships. I also explore the training cultures of Dog A.I.D. whilst also spotlighting the lived experiences of training through the early stages of ‘socialisation’, ‘familiarisation’, ‘life skills training’, through to ‘task work’. Finally, the thesis focuses on the practices of care that characterise the assistance dog partnership, showing how care is provided and received by both human and nonhuman. I pay attention to the complex potentiality of the partnership, illustrating how dogs are trained to assist, but also how dogs appear to embody lively, agentic, moments of care. The thesis contributes original work which speaks to animal and disability geographies and attends to the multiple geographies of care-full cross-species lives

    The Politics of Local Disaster Management in Thailand, A Poststructuralist Discourse Analysis of Earthquake Governance in the Upper Northern Region

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    Although disaster management has become an effective approach through which the security of society can be secured, it has produced failure and conflict in some circumstances. The academic approach given to this phenomena has often been criticised, namely in relation to how attention is given predominantly to technical and positivist means and thus how social and political dimensions are not adequately considered. Importantly, these neglected factors play a crucial role in determining the success and/or failure of disaster management. Drawing upon Poststructuralist Discourse Theory, this thesis develops a new conceptual framework to critically explain the politics of disaster management, thus revealing the issues that are embedded in the construction of, and political practices involved in responding to, disaster management. It further analyses the politics of disaster management surrounding the 2014 Chiang Rai Earthquake of Thailand. At the national level, the thesis characterises disaster management via four key logics - security, bureaucracy, managerialism and hybridity - showing how their merging in a hybrid form has caused failure/conflict. The discourses that surfaced in this context are demonstrated to have manifested a political space in which local residents used logics of the community to politicise issues and to challenge the state. Conversely, logics of uncertainty and professionalisation were used as de/re-politicisation mechanisms by provincial agencies to regain authority. This thesis considers such disaster management as contested political terrain where political strategies were implemented through anti- and pro-central disaster management projects. The thesis contributes to Disaster Management Studies in three ways – by offering an alternative means of conducting research as to disaster management politics, exemplifying the benefits of applying a logics approach in explaining the political practices involved in disaster management and calling for further analysis to be given as to the role of subjective desires and the affective register in this field

    Optimización del rendimiento y la eficiencia energética en sistemas masivamente paralelos

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    RESUMEN Los sistemas heterogĂ©neos son cada vez mĂĄs relevantes, debido a sus capacidades de rendimiento y eficiencia energĂ©tica, estando presentes en todo tipo de plataformas de cĂłmputo, desde dispositivos embebidos y servidores, hasta nodos HPC de grandes centros de datos. Su complejidad hace que sean habitualmente usados bajo el paradigma de tareas y el modelo de programaciĂłn host-device. Esto penaliza fuertemente el aprovechamiento de los aceleradores y el consumo energĂ©tico del sistema, ademĂĄs de dificultar la adaptaciĂłn de las aplicaciones. La co-ejecuciĂłn permite que todos los dispositivos cooperen para computar el mismo problema, consumiendo menos tiempo y energĂ­a. No obstante, los programadores deben encargarse de toda la gestiĂłn de los dispositivos, la distribuciĂłn de la carga y la portabilidad del cĂłdigo entre sistemas, complicando notablemente su programaciĂłn. Esta tesis ofrece contribuciones para mejorar el rendimiento y la eficiencia energĂ©tica en estos sistemas masivamente paralelos. Se realizan propuestas que abordan objetivos generalmente contrapuestos: se mejora la usabilidad y la programabilidad, a la vez que se garantiza una mayor abstracciĂłn y extensibilidad del sistema, y al mismo tiempo se aumenta el rendimiento, la escalabilidad y la eficiencia energĂ©tica. Para ello, se proponen dos motores de ejecuciĂłn con enfoques completamente distintos. EngineCL, centrado en OpenCL y con una API de alto nivel, favorece la mĂĄxima compatibilidad entre todo tipo de dispositivos y proporciona un sistema modular extensible. Su versatilidad permite adaptarlo a entornos para los que no fue concebido, como aplicaciones con ejecuciones restringidas por tiempo o simuladores HPC de dinĂĄmica molecular, como el utilizado en un centro de investigaciĂłn internacional. Considerando las tendencias industriales y enfatizando la aplicabilidad profesional, CoexecutorRuntime proporciona un sistema flexible centrado en C++/SYCL que dota de soporte a la co-ejecuciĂłn a la tecnologĂ­a oneAPI. Este runtime acerca a los programadores al dominio del problema, posibilitando la explotaciĂłn de estrategias dinĂĄmicas adaptativas que mejoran la eficiencia en todo tipo de aplicaciones.ABSTRACT Heterogeneous systems are becoming increasingly relevant, due to their performance and energy efficiency capabilities, being present in all types of computing platforms, from embedded devices and servers to HPC nodes in large data centers. Their complexity implies that they are usually used under the task paradigm and the host-device programming model. This strongly penalizes accelerator utilization and system energy consumption, as well as making it difficult to adapt applications. Co-execution allows all devices to simultaneously compute the same problem, cooperating to consume less time and energy. However, programmers must handle all device management, workload distribution and code portability between systems, significantly complicating their programming. This thesis offers contributions to improve performance and energy efficiency in these massively parallel systems. The proposals address the following generally conflicting objectives: usability and programmability are improved, while ensuring enhanced system abstraction and extensibility, and at the same time performance, scalability and energy efficiency are increased. To achieve this, two runtime systems with completely different approaches are proposed. EngineCL, focused on OpenCL and with a high-level API, provides an extensible modular system and favors maximum compatibility between all types of devices. Its versatility allows it to be adapted to environments for which it was not originally designed, including applications with time-constrained executions or molecular dynamics HPC simulators, such as the one used in an international research center. Considering industrial trends and emphasizing professional applicability, CoexecutorRuntime provides a flexible C++/SYCL-based system that provides co-execution support for oneAPI technology. This runtime brings programmers closer to the problem domain, enabling the exploitation of dynamic adaptive strategies that improve efficiency in all types of applications.Funding: This PhD has been supported by the Spanish Ministry of Education (FPU16/03299 grant), the Spanish Science and Technology Commission under contracts TIN2016-76635-C2-2-R and PID2019-105660RB-C22. This work has also been partially supported by the Mont-Blanc 3: European Scalable and Power Efficient HPC Platform based on Low-Power Embedded Technology project (G.A. No. 671697) from the European Union’s Horizon 2020 Research and Innovation Programme (H2020 Programme). Some activities have also been funded by the Spanish Science and Technology Commission under contract TIN2016-81840-REDT (CAPAP-H6 network). The Integration II: Hybrid programming models of Chapter 4 has been partially performed under the Project HPC-EUROPA3 (INFRAIA-2016-1-730897), with the support of the EC Research Innovation Action under the H2020 Programme. In particular, the author gratefully acknowledges the support of the SPMT Department of the High Performance Computing Center Stuttgart (HLRS)
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