9,535 research outputs found
Deep learning for extracting protein-protein interactions from biomedical literature
State-of-the-art methods for protein-protein interaction (PPI) extraction are
primarily feature-based or kernel-based by leveraging lexical and syntactic
information. But how to incorporate such knowledge in the recent deep learning
methods remains an open question. In this paper, we propose a multichannel
dependency-based convolutional neural network model (McDepCNN). It applies one
channel to the embedding vector of each word in the sentence, and another
channel to the embedding vector of the head of the corresponding word.
Therefore, the model can use richer information obtained from different
channels. Experiments on two public benchmarking datasets, AIMed and BioInfer,
demonstrate that McDepCNN compares favorably to the state-of-the-art
rich-feature and single-kernel based methods. In addition, McDepCNN achieves
24.4% relative improvement in F1-score over the state-of-the-art methods on
cross-corpus evaluation and 12% improvement in F1-score over kernel-based
methods on "difficult" instances. These results suggest that McDepCNN
generalizes more easily over different corpora, and is capable of capturing
long distance features in the sentences.Comment: Accepted for publication in Proceedings of the 2017 Workshop on
Biomedical Natural Language Processing, 10 pages, 2 figures, 6 table
Multi texture analysis of colorectal cancer continuum using multispectral imagery
Purpose
This paper proposes to characterize the continuum of colorectal cancer (CRC) using multiple texture features extracted from multispectral optical microscopy images. Three types of pathological tissues (PT) are considered: benign hyperplasia, intraepithelial neoplasia and carcinoma.
Materials and Methods
In the proposed approach, the region of interest containing PT is first extracted from multispectral
images using active contour segmentation. This region is then encoded using texture features based on the Laplacian-of-Gaussian (LoG) filter, discrete wavelets (DW) and gray level co-occurrence matrices (GLCM). To assess the significance of textural differences between PT types, a statistical analysis based on the Kruskal-Wallis test is performed. The usefulness of texture features is then evaluated quantitatively in terms of their ability to predict PT types using various classifier models.
Results
Preliminary results show significant texture differences between PT types, for all texture features (p-value < 0.01). Individually, GLCM texture features outperform LoG and DW features in terms of PT type prediction. However, a higher performance can be achieved by combining all texture features, resulting in a mean classification accuracy of 98.92%, sensitivity of 98.12%, and specificity of 99.67%.
Conclusions
These results demonstrate the efficiency and effectiveness of combining multiple texture features for characterizing the continuum of CRC and discriminating between pathological tissues in multispectral images
Chemical named entities recognition: a review on approaches and applications
The rapid increase in the flow rate of published digital information in all disciplines has resulted in a pressing need for techniques that can simplify the use of this information. The chemistry literature is very rich with information about chemical entities. Extracting molecules and their related properties and activities from the scientific literature to "text mine" these extracted data and determine contextual relationships helps research scientists, particularly those in drug development. One of the most important challenges in chemical text mining is the recognition of chemical entities mentioned in the texts. In this review, the authors briefly introduce the fundamental concepts of chemical literature mining, the textual contents of chemical documents, and the methods of naming chemicals in documents. We sketch out dictionary-based, rule-based and machine learning, as well as hybrid chemical named entity recognition approaches with their applied solutions. We end with an outlook on the pros and cons of these approaches and the types of chemical entities extracte
Citation Function and Polarity Classification in Biomedical Papers
The traditional reference evaluation method treats all citations equally. However, a citation can serve various functions. It may reflect the citing paper author’s motivation as well as his/her true attitude towards the cited paper. Investigating such information can be achieved through citation content analysis.
This thesis develops an 8-category classification scheme on citation function and polarity to help understand what role a citation played in scientific papers. A biomedical citation corpus is annotated with this scheme and experimented with supervised machine learning methods. Several types of features that capture the characteristics of citation sentences are extracted by natural language processing techniques to serve as the inputs of automatic classifiers. The importance of cue phrases in citation classification is also addressed and discussed
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