115 research outputs found

    Transimpedance amplifier for early detection of breast cancer

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    Breast cancer is the most common type of cancer worldwide. The effectiveness of its treatment depends on early stage detection, as well as on the accuracy of its diagnosis. Recently, diagnosis techniques have been submitted to relevant breakthroughs with the upcoming of Magnetic Resonance Imaging, Ultrasound Sonograms and Positron Emission Tomography (PET) scans, among others. The work presented here is focused on studying the application of a PET system to a Positron Emission Mammography (PEM) system. A PET/PEM system works under the principle that a scintillating crystal will detect a gamma-ray pulse, originated at the cancerous cells, converting it into a correspondent visible light pulse. The latter must then be converted into an electrical current pulse by means of a Photo- -Sensitive Device (PSD). After the PSD there must be a Transimpedance Amplifier (TIA) in order to convert the current pulse into a suitable output voltage, in a time period lower than 40 ns. In this Thesis, the PSD considered is a Silicon Photo-Multiplier (SiPM). The usage of this recently developed type of PSD is impracticable with the conventional TIA topologies, as it will be proven. Therefore, the usage of the Regulated Common-Gate (RCG) topology will be studied in the design of the amplifier. There will be also presented two RCG variations, comprising a noise response improvement and differential operation of the circuit. The mentioned topology will also be tested in a Radio-Frequency front-end, showing the versatility of the RCG. A study comprising a low-voltage self-biasing feedback TIA will also be shown. The proposed circuits will be simulated with standard CMOS technology (UMC 130 nm), using a 1.2 V power supply. A power consumption of 0.34 mW with a signal-to-noise ratio of 43 dB was achieved

    TOFPET2: A high-performance ASIC for time and amplitude measurements of SiPM signals in time-of-flight applications

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    We present a readout and digitization ASIC featuring low-noise and low-power for time-of flight (TOF) applications using SiPMs. The circuit is designed in standard CMOS 110 nm technology, has 64 independent channels and is optimized for time-of-flight measurement in Positron Emission Tomography (TOF-PET). The input amplifier is a low impedance current conveyor based on a regulated common-gate topology. Each channel has quad-buffered analogue interpolation TDCs (time binning 20 ps) and charge integration ADCs with linear response at full scale (1500 pC). The signal amplitude can also be derived from the measurement of time-over-threshold (ToT). Simulation results show that for a single photo-electron signal with charge 200 (550) fC generated by a SiPM with 320 pF capacitance the circuit has 24 (30) dB SNR, 75(39) ps r.m.s. resolution, and 4(8) mW power consumption. The event rate is 600 kHz per channel, with up to 2 MHz dark counts rejection

    A Bulk Driven Transimpedance CMOS Amplifier for SiPM Based Detection

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    The contribution of this work lies in the development of a bulk driven operationaltransconducctance amplifier which can be integrated with other analog circuits andphotodetectors in the same chip for compactness, miniaturization and reducing thepower. Silicon photomultipliers, also known as SiPMs, when coupled with scintillator materials are used in many imaging applications including nuclear detection. This thesis discuss the design of a bulk-driven transimpedance amplifier suitable for detectors where the front end is a SiPM. The amplifier was design and fabricated in a standard standard CMOS process and is suitable for integration with CMOS based SiPMs and commercially available SiPMs. Specifically, the amplifier was verified in simulations and experiment using circuit models for the SiPM. The bulk-driven amplifier’s performance, was compared to a commerciallyavailable amplifier with approximately the same open loop gain (70dB). Bothamplifiers were verified with two different light sources, a scintillator and a SiPM.The energy resolution using the bulk driven amplifier was 8.6% and was 14.2% forthe commercial amplifier indicating the suitability of the amplifier design for portable systems

    Analysis and Design of Analog Front-end Circuitry for Avalanche Photodiodes (APD) and Silicon Photo-multipliers (SiPM) in Time-of-flight Applications

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    This thesis reports the analysis and design of analog front-end circuitry for reading out signals from avalanche photodiodes (APD) or silicon photomultiplier (SiPM) in time-of-flight (ToF) applications. An integrated circuit was designed using AMS SiGe 0.35 um BiCMOS process. The chip measured 2 mm x 2 mm (2000 umx2000 um). The chip mainly contains the following circuits: an APD with photoactive area measuring 24 umx24 um, an SiPM with 8x8 APDs with 236 k ohm quench resistors, a transimpedance amplifier (TIA), a comparator and a R-2R digital to analog converter (DAC). The TIA is based on the shunt-shunt feedback topology. The TIA gain can be digitally set using two input bits to range from -0.9 k ohm to -14.44 k ohm with a bandwidth ranging from 93 MHz to 113 MHz. Photodetector capacitance on TIA input reduces the bandwidth. The maximum positive input current dynamic range of the TIA is 294 uA. The TIA consumes a power of 7.1 mW. The comparator has a maximum speed of 265 MHz with input sensitivity down to 50 uV and consumes about 6.6 mW of power. The R-2R DAC has a 10-bit resolution with maximum differential nonlinearity (DNL) and integral nonlinearity (INL) of -0.14 LSB and -0.09 LSB respectively with no load. Design considerations for all the blocks are given and simulation results are compared to hand calculations. The TIA, comparator and DAC are connected as a system and the simulation is functional. Using this system to implement a time-of-flight LiDAR (light detection and ranging), a range resolution down to 1.2 m (3.9 ft) can be achieved with photodetector capacitance of 0.1 pF

    Techniques for signal to noise ratio adaptation in infared optical wireless for optimisation of receiver performance

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    The challenge of creating a new environment of links for wireless infrared and optical local area networks (LANs) is driving new innovations in the design of optical transceivers. This thesis is concerned with a systematic approach to the design of receivers for indoor optical wireless communication. In particular, it is concerned with how to offer bandwidth adjustment capability in a receiver according to the dynamic service quality of the incoming signals. Another part of the discussion of the thesis is how one can properly choose the front-end preamplifier and biasing circuitry for the photodetector. Also, comparison is made between different types of amplifier, and the methods of bandwidth enhancement. The designs of six different techniques of integrating transimpedance amplifiers, with photodetectors to adapt an adjustable bandwidth control receiver are discussed. The proposed topologies provide an adjustable range of bandwidths for different frequency ranges, typically between 52Hz to 115MHz. The composite technique designs were used to incorporate into a system with an automatic gain control to study its effect, on an optical wireless receiver which had bandwidth adjustment and automatic gain adjustment. Theoretical analysis of noise performance for all the designed circuits is also presented. The theory and design of obstacles of indoor optical wireless receiver delivery, in addition to techniques for mitigating these effects, are discussed. This shows that infrared is a viable alternative to ratio for certain applications

    Modelling, Analysis and Design of Optimised Electronic Circuits for Visible Light Communication Systems

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    This thesis explores new circuit design techniques and topologies to extend the bandwidth of visible light communication (VLC) transmitters and receivers, by ameliorating the bandwidth-limiting effects of commonly used optoelectronic devices. The thesis contains detailed literature review of transmitter and receiver designs, which inspired two directions of work. The first proposes new designs of optically lossless light emitting diode (LED) bandwidth extension technique that utilises a negative capacitance circuit to offset the diode’s bandwidth-limiting capacitance. The negative capacitance circuit was studied and verified through newly developed mathematical analysis, modelling and experimental demonstration. The bandwidth advantage of the proposed technique was demonstrated through measurements in conjunction with several colour LEDs, demonstrating up to 500% bandwidth extension with no loss of optical power. The second direction of work enhances the bandwidth of VLC receivers through new designs of ultra-low input impedance transimpedance amplifiers (TIAs), designed to be insensitive to the high photodiode capacitances (Cpd) of large area detectors. Moreover, the thesis proposes a new circuit, which modifies the traditional regulated cascode (RGC) circuit to enhance its bandwidth and gain. The modified RGC amplifier efficiently treats significant RGC inherent bandwidth limitations and is shown, through mathematical analysis, modelling and experimental measurements to extend the bandwidth further by up to 200%. The bandwidth advantage of such receivers was demonstrated in measurements, using several large area photodiodes of area up to 600 mm^2, resulting in a substantial bandwidth improvement of up to 1000%, relative to a standard 50 Ω termination. An inherent limitation of large area photodiodes, associated with internal resistive elements, was identified and ameliorated, through the design of negative resistance circuits. Altogether, this research resulted in a set of design methods and practical circuits, which will hopefully contribute to wider adoption of VLC systems and may be applied in areas beyond VLC

    Design and implementation of miniaturised capsule for autofluorescence detection with possible application to the bowel disease

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    Early signs of intestinal cancer may be detected through variations in tissue autofluorescence (AF), however current endoscope-based AF systems are unable to inspect the small intestine. This thesis describes the design, fabrication, implantation, testing and packaging of a wireless pill capable of detecting the autofluorescence from cancerous cells, and able to reach parts of the gastrointestinal tract that are inaccessible to endoscopes. The pill exploits the fact that there is a significant difference in the intensity of autofluorescence emitted by normal and cancerous tissues when excited by a blue or ultra violet light source. The intensity differences are detected using very sensitive light detectors. The pill has been developed in two stages. The first stage starts with using an off-chip multi-pixel photon counter (MPPC) device as a light detector. In the second stage, the light detector is integrated into an application specific integrated circuit (ASIC). The pill comprises of an ASIC, optical filters, an information processing unit and a radio transmission unit, to transmit acquired data to an external base station. Two ASICs have been fabricated, the first stage of this work involved implementing an ASIC that contains two main blocks; the first block is capable of providing a variable DC voltage more than 72 V from a 3 V input to bias the MPPC device. The second main block is a front-end consisting of a high speed transimpedance amplifier (TIA) and voltage amplifiers to capture the very small current pulses produced by the MPPC. The second ASIC contains a high voltage charge pump up to (37.9 V) integrated with a single photon avalanche detector (SPAD). The charge pump is used to bias the SPAD above its breakdown voltage and therefore operate the device in Geiger mode. The SPAD was designed to operate in the visible region where its photon detection efficiency (PDE) peaks at 465 nm, which is near to human tissues autofluorescence peaking region (520±10 nm). The use of the ultra low light detector to detect the autofluorescence permits a lower excitation light intensity and therefore lower overall power consumption. The two ASICs were fabricated using a commercial triple-well high-voltage CMOS process. The complete device operates at 3V and draws an average of 7.1mA, enabling up to 23 hours of continuous operation from two 165mAh SR44 batteries

    Development of ASIC for SiPM sensor readout

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    L'abstract è presente nell'allegato / the abstract is in the attachmen

    5 GHz Optical Front End in 0.35um CMOS

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    With the advantages of low cost, low power consumption, high reliability and potential for large scale integration, CMOS monolithically integrated active pixel chips have significant application in optical sensing systems. The optical front end presented in this thesis will have application in Optical Scanning Acoustic Microscope System (O-SAM), which involves a totally non-contact method of acquiring images of the interaction between surface acoustic waves (SAWs) and a solid material to be characterized. In this work, an ultra fast optical front-end using improved regulated cascade scheme is developed based on AMS 0.35mm CMOS technology. The receiver consists of an integrated photodiode, a transimpedance amplifier, a mixer, an IF amplifier and an output buffer. By treating the n-well in standard CMOS technology as a screening terminal to block the slow photo-generated bulk carriers and interdigitizing shallow p+ junctions as the active region, the integrated photodiode operates up to 4.9 GHz with no process modification. Its responsivity was measured to be 0.016 A/W. With multi-inductive-series peaking technique, the improved ReGulated-Cascade (RGC) transimpedance amplifier achieves an experimentally measured -3dB bandwidth of more than 6 GHz and a transimpedance gain of 51 dBW, which is the fastest reported TIA in CMOS 0.35mm technology. The 5 GHz Gilbert cell mixer produces a conversion gain of 11 dB, which greatly minimized the noise contribution from the IF stage. The noise figure and input IIP3 of the mixer were measured to be 15.7 dB and 1.5 dBm, respectively. The IF amplifier and output buffer pick up and further amplify the signal for post processing. The optical front end demonstrates a typical equivalent input noise current of 35 pA=pHz at 5 GHz, and a total transimpedance gain of 83 dB ohm whileconsuming a total current of 40 mA from 3.3 V power supply. The -3 dB bandwidth for the optical front end was measured to be 4.9 GHz. All the prototype chips, including the optical front end, and the individual circuits including the photodiode, TIA, mixer were probe-tested and all the measurements were taken with Anritsu VNA 37397D and Anritsu spectrum analyser MS2721A

    5 GHz Optical Front End in 0.35um CMOS

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    With the advantages of low cost, low power consumption, high reliability and potential for large scale integration, CMOS monolithically integrated active pixel chips have significant application in optical sensing systems. The optical front end presented in this thesis will have application in Optical Scanning Acoustic Microscope System (O-SAM), which involves a totally non-contact method of acquiring images of the interaction between surface acoustic waves (SAWs) and a solid material to be characterized. In this work, an ultra fast optical front-end using improved regulated cascade scheme is developed based on AMS 0.35mm CMOS technology. The receiver consists of an integrated photodiode, a transimpedance amplifier, a mixer, an IF amplifier and an output buffer. By treating the n-well in standard CMOS technology as a screening terminal to block the slow photo-generated bulk carriers and interdigitizing shallow p+ junctions as the active region, the integrated photodiode operates up to 4.9 GHz with no process modification. Its responsivity was measured to be 0.016 A/W. With multi-inductive-series peaking technique, the improved ReGulated-Cascade (RGC) transimpedance amplifier achieves an experimentally measured -3dB bandwidth of more than 6 GHz and a transimpedance gain of 51 dBW, which is the fastest reported TIA in CMOS 0.35mm technology. The 5 GHz Gilbert cell mixer produces a conversion gain of 11 dB, which greatly minimized the noise contribution from the IF stage. The noise figure and input IIP3 of the mixer were measured to be 15.7 dB and 1.5 dBm, respectively. The IF amplifier and output buffer pick up and further amplify the signal for post processing. The optical front end demonstrates a typical equivalent input noise current of 35 pA=pHz at 5 GHz, and a total transimpedance gain of 83 dB ohm whileconsuming a total current of 40 mA from 3.3 V power supply. The -3 dB bandwidth for the optical front end was measured to be 4.9 GHz. All the prototype chips, including the optical front end, and the individual circuits including the photodiode, TIA, mixer were probe-tested and all the measurements were taken with Anritsu VNA 37397D and Anritsu spectrum analyser MS2721A
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