6,965 research outputs found

    Shaping a screening file for maximal lead discovery efficiency and effectiveness: elimination of molecular redundancy

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    High Throughput Screening (HTS) is a successful strategy for finding hits and leads that have the opportunity to be converted into drugs. In this paper we highlight novel computational methods used to select compounds to build a new screening file at Pfizer and the analytical methods we used to assess their quality. We also introduce the novel concept of molecular redundancy to help decide on the density of compounds required in any region of chemical space in order to be confident of running successful HTS campaigns

    Coreference detection of low quality objects

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    The problem of record linkage is a widely studied problem that aims to identify coreferent (i.e. duplicate) data in a structured data source. As indicated by Winkler, a solution to the record linkage problem is only possible if the error rate is sufficiently low. In other words, in order to succesfully deduplicate a database, the objects in the database must be of sufficient quality. However, this assumption is not always feasible. In this paper, it is investigated how merging of low quality objects into one high quality object can improve the process of record linkage. This general idea is illustrated in the context of strings comparison, where strings of low quality (i.e. with a high typographical error rate) are merged into a string of high quality by using an n-dimensional Levenshtein distance matrix and compute the optimal alignment between the dirty strings. Results are presented and possible refinements are proposed

    Automated Students Result Management System Using Oracle’s Database, Forms and Reports

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    This research is focused on creating an automated students result management system using oracle’s database, forms and reports. This is a computerized examinations results management system for tertiary student’s examination records. The manual method of students’ academic result processing was found to be tedious, especially when carried out for a large number of students, this makes the entire process time-consuming and error prone. The system designed is meant to register students as soon as they have paid their departmental registration and only then will they be able to view their results. The system presents a single platform that will be used to manage the processing of all examination records within the institution. The data used for testing was obtained from the Department of Physics, Nasarawa State University and an empirical evaluation of the system shows that the system expedites the processing of students’ examination results and the reporting of it. Keywords: Oracle Database, Oracle forms, Oracl

    Creating a Relational Distributed Object Store

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    In and of itself, data storage has apparent business utility. But when we can convert data to information, the utility of stored data increases dramatically. It is the layering of relation atop the data mass that is the engine for such conversion. Frank relation amongst discrete objects sporadically ingested is rare, making the process of synthesizing such relation all the more challenging, but the challenge must be met if we are ever to see an equivalent business value for unstructured data as we already have with structured data. This paper describes a novel construct, referred to as a relational distributed object store (RDOS), that seeks to solve the twin problems of how to persistently and reliably store petabytes of unstructured data while simultaneously creating and persisting relations amongst billions of objects.Comment: 12 pages, 5 figure

    Reboot

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    I am an artist that works with technologically obsolete materials in order to elevate them to have purely aesthetic, sublime qualities. Creating my art this way has led me to profile and understand hoarders; those who collect materials that are otherwise socially useless. They collect these objects to the point where the collection act becomes an obsessive psychological disorder. This thesis will prove that while I identify with those who struggle with this disorder, my own collection tendencies lend themselves to being more related to the processes of contemporary artists and their need to reconfigure the original use of objects in multitude
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