Wavelet feature extraction and genetic algorithm for biomarker detection in colorectal cancer data

Biomarkers which predict patient’s survival can play an important role in medical diagnosis and treatment. How to select the significant biomarkers from hundreds of protein markers is a key step in survival analysis. In this paper a novel method is proposed to detect the prognostic biomarkers ofsurvival in colorectal cancer patients using wavelet analysis, genetic algorithm, and Bayes classifier. One dimensional discrete wavelet transform (DWT) is normally used to reduce the dimensionality of biomedical data. In this study one dimensional continuous wavelet transform (CWT) was proposed to extract the features of colorectal cancer data. One dimensional CWT has no ability to reduce dimensionality of data, but captures the missing features of DWT, and is complementary part of DWT. Genetic algorithm was performed on extracted wavelet coefficients to select the optimized features, using Bayes classifier to build its fitness function. The corresponding protein markers were located based on the position of optimized features. Kaplan-Meier curve and Cox regression model 2 were used to evaluate the performance of selected biomarkers. Experiments were conducted on colorectal cancer dataset and several significant biomarkers were detected. A new protein biomarker CD46 was found to significantly associate with survival time

EMPATH: A Neural Network that Categorizes Facial Expressions

There are two competing theories of facial expression recognition. Some researchers have suggested that it is an example of "categorical perception." In this view, expression categories are considered to be discrete entities with sharp boundaries, and discrimination of nearby pairs of expressive faces is enhanced near those boundaries. Other researchers, however, suggest that facial expression perception is more graded and that facial expressions are best thought of as points in a continuous, low-dimensional space, where, for instance, "surprise" expressions lie between "happiness" and "fear" expressions due to their perceptual similarity. In this article, we show that a simple yet biologically plausible neural network model, trained to classify facial expressions into six basic emotions, predicts data used to support both of these theories. Without any parameter tuning, the model matches a variety of psychological data on categorization, similarity, reaction times, discrimination, and recognition difficulty, both qualitatively and quantitatively. We thus explain many of the seemingly complex psychological phenomena related to facial expression perception as natural consequences of the tasks' implementations in the brain

Various Approaches of Support vector Machines and combined Classifiers in Face Recognition

In this paper we present the various approaches used in face recognition from 2001-2012.because in last decade face recognition is using in many fields like Security sectors, identity authentication. Today we need correct and speedy performance in face recognition. This time the face recognition technology is in matured stage because research is conducting continuously in this field. Some extensions of Support vector machine (SVM) is reviewed that gives amazing performance in face recognition.Here we also review some papers of combined classifier approaches that is also a dynamic research area in a pattern recognition