A Review of Aeronautical Fatigue Investigations in Finland May 2021 - April 2023

This document was prepared for the delivery to the 38th Conference of the International Committee on Aeronautical Fatigue and Structural Integrity (ICAF) scheduled to be held in Delft, The Netherlands, 26-29 June 2023.A review is given of the aircraft structural fatigue research and associated activities which form part of the programs within the Air Force Command Finland (AFCOMFIN), the Finnish Defence Force Logistics Command, Joint Systems Centre (FDFLOGCOM JSC), Air Systems Division; Army Command Finland (ARCOMFIN); Aalto University; Arecap Ltd; Elomatic Ltd; Emmecon Ltd; Eurofins Expert Services Oy; Insta ILS Oy; Patria Aviation Oy; Tampere University; Trano Oy; Trueflaw Ltd; and VTT Technical Research Centre of Finland Ltd (VTT).The review summarizes fatigue related research programs and investigations on specific military aircraft since the previous Finnish National Review compiled for the International Committee on Aeronautical Fatigue and Structural Integrity (ICAF) webinar, 30 June 2021

Smart Sensors for Healthcare and Medical Applications

This book focuses on new sensing technologies, measurement techniques, and their applications in medicine and healthcare. Specifically, the book briefly describes the potential of smart sensors in the aforementioned applications, collecting 24 articles selected and published in the Special Issue “Smart Sensors for Healthcare and Medical Applications”. We proposed this topic, being aware of the pivotal role that smart sensors can play in the improvement of healthcare services in both acute and chronic conditions as well as in prevention for a healthy life and active aging. The articles selected in this book cover a variety of topics related to the design, validation, and application of smart sensors to healthcare

Análise do HEVC escalável : desempenho e controlo de débito

Mestrado em Engenharia Eletrónica e TelecomunicaçõesEsta dissertação apresenta um estudo da norma de codificação de vídeo de alta eficiência (HEVC) e a sua extensão para vídeo escalável, SHVC. A norma de vídeo SHVC proporciona um melhor desempenho quando codifica várias camadas em simultâneo do que quando se usa o codificador HEVC numa configuração simulcast. Ambos os codificadores de referência, tanto para a camada base como para a camada superior usam o mesmo modelo de controlo de débito, modelo R-λ, que foi otimizado para o HEVC. Nenhuma otimização de alocação de débito entre camadas foi até ao momento proposto para o modelo de testes (SHM 8) para a escalabilidade do HEVC (SHVC). Derivamos um novo modelo R-λ apropriado para a camada superior e para o caso de escalabilidade espacial, que conduziu a um ganho de BD-débito de 1,81% e de BD-PSNR de 0,025 em relação ao modelo de débito-distorção existente no SHM do SHVC. Todavia, mostrou-se também nesta dissertação que o proposto modelo de R-λ não deve ser usado na camada inferior (camada base) no SHVC e por conseguinte no HEVC.This dissertation provides a study of the High Efficiency Video Coding standard (HEVC) and its scalable extension, SHVC. The SHVC provides a better performance when encoding several layers simultaneously than using an HEVC encoder in a simulcast configuration. Both reference encoders, in the base layer and in the enhancement layer use the same rate control model, R-λ model, which was optimized for HEVC. No optimal bitrate partitioning amongst layers is proposed in scalable HEVC (SHVC) test model (SHM 8). We derived a new R-λ model for the enhancement layer and for the spatial case which led to a DB-rate gain of 1.81% and DB-PSNR gain of 0.025 in relation to the rate-distortion model of SHM-SHVC. Nevertheless, we also show in this dissertation that the proposed model of R-λ should not be used neither in the base layer nor in HEVC

Mobile Diagnosis 2.0

Mobile sensing and diagnostic capabilities are becoming extremely important for a wide range of emerging applications and fields spanning mobile health, telemedicine, point-of-care diagnostics, global health, field medicine, democratization of sensing and diagnostic tools, environmental monitoring, and citizen science, among many others. The importance of low-cost mobile technologies has been underlined during this current COVID-19 pandemic, particularly for applications such as the detection of pathogens, including bacteria and viruses, as well as for prediction and management of different diseases and disorders. This book focuses on some of these application areas and provides a timely summary of cutting-edge results and emerging technologies in these interdisciplinary fields

Models and Analysis of Vocal Emissions for Biomedical Applications

The International Workshop on Models and Analysis of Vocal Emissions for Biomedical Applications (MAVEBA) came into being in 1999 from the particularly felt need of sharing know-how, objectives and results between areas that until then seemed quite distinct such as bioengineering, medicine and singing. MAVEBA deals with all aspects concerning the study of the human voice with applications ranging from the neonate to the adult and elderly. Over the years the initial issues have grown and spread also in other aspects of research such as occupational voice disorders, neurology, rehabilitation, image and video analysis. MAVEBA takes place every two years always in Firenze, Italy

Smartphone-based systems for mobile infectious disease detection and epidemiology

Infectious diseases remain a serious public health challenge worldwide and are the leading cause of death in many developing countries. The rapid detection of pathogens is vital for the control and prevention of the infectious diseases. New tools are needed to enable rapid detection, identification, and reporting of infectious viral and microbial pathogens in a wide variety of point-of-care applications that impact human and animal health. With the rapid development of mobile technologies, mobile devices have provided a novel and effective approach to identify and report infectious diseases. In this work, two types of smartphone-based detection platforms are developed for mobile infectious disease detection. The first one is for the detection of human immunodeficiency virus. The second one is for the multiplexed detection of nucleic acids of pathogens for equine respiratory infections. Both platforms utilize a smartphone camera as the sensor in conjunction with a handheld cradle that interfaces the phone with a microchip for the on-chip nucleic acid testing of infectious diseases. This work provides a mobile, simple and inexpensive capability for clinicians to perform infectious disease diagnostics, and it represents a significant stride towards a practical solution to the infectious disease diagnostics at resource-limited settings.Ope

Point-of-Care Detection Devices for Healthcare

With recent technological advances in multiple research fields such as materials science, micro-/nano-technology, cellular and molecular biology, bioengineering and the environment, much attention is shifting toward the development of new detection tools that not only address needs for high sensitivity and specificity but fulfil economic, environmental, and rapid point-of-care needs for groups and individuals with constrained resources and, possibly, limited training. Miniaturized fluidics-based platforms that precisely manipulate tiny body fluid volumes can be used for medical, healthcare or even environmental (e.g., heavy metal detection) diagnosis in a rapid and accurate manner. These new detection technologies are potentially applicable to different healthcare or environmental issues, since they are disposable, inexpensive, portable, and easy to use for the detection of human diseases or environmental issues—especially when they are manufactured based on low-cost materials, such as paper. The topics in this book (original and review articles) would cover point-of-care detection devices, microfluidic or paper-based detection devices, new materials for making detection devices, and others

An aptamer-based sensing platform for luteinising hormone pulsatility measurement

Normal fertility in human involves highly orchestrated communication across the hypothalamic-pituitary-gonadal (HPG) axis. The pulsatile release of Luteinising Hormone (LH) is a critical element for downstream regulation of sex steroid hormone synthesis and the production of mature eggs. Changes in LH pulsatile pattern have been linked to hypothalamic dysfunction, resulting in multiple reproductive and growth disorders including Polycystic Ovary Syndrome (PCOS), Hypothalamic Amenorrhea (HA), and delayed/precocious puberty. Therefore, assessing the pulsatility of LH is important not only for academic investigation of infertility, but also for clinical decisions and monitoring of treatment. However, there is currently no clinically available tool for measuring human LH pulsatility. The immunoassay system is expensive and requires large volumes of patient blood, limiting its application for LH pulsatility monitoring. In this thesis, I propose a novel method using aptamer-enabled sensing technology to develop a device platform to measure LH pulsatility. I first generated a novel aptamer binding molecule against LH by a nitrocellulose membrane-based in vitro selection then characterised its high affinity and specific binding properties by multiple biophysical/chemical methods. I then developed a sensitive electrochemical-based detection method using this aptamer. The principal mechanism is that structure switching upon binding is associated with the electron transfer rate changes of the MB redox label. I then customised this assay to numerous device platforms under our rapid prototyping strategy including 96 well automated platform, continuous sensing platform and chip-based multiple electrode platform. The best-performing device was found to be the AELECAP (Automated ELEctroChemical Aptamer Platform) – a 96-well plate based automatic micro-wire sensing platform capable of measuring a series of low volume luteinising hormone within a short time. Clinical samples were evaluated using AELECAP. A series of clinical samples were measured including LH pulsatility profile of menopause female (high LH amplitude), normal female/male (normal LH amplitude) and female with hypothalamic amenorrhea (no LH pulsatility). Total patient numbers were 12 of each type, with 50 blood samples collected every 10 mins in 8 hours. Results showed that the system can distinguish LH pulsatile pattern among the cohorts and pulsatility profiles were consistent with the result measured by clinical assays. AELECAP shows high potential as a novel approach for clinical aptamer-based sensing. AELECAP competes with current automated immunometric assays system with lower costs, lower reagent use, and a simpler setup. There is potential for this approach to be further developed as a tool for infertility research and to assist clinicians in personalised treatment with hormonal therapy.Open Acces