Design and control methodology of a lower extremity assistive device

Ph.DDOCTOR OF PHILOSOPH

Sensing and Signal Processing in Smart Healthcare

In the last decade, we have witnessed the rapid development of electronic technologies that are transforming our daily lives. Such technologies are often integrated with various sensors that facilitate the collection of human motion and physiological data and are equipped with wireless communication modules such as Bluetooth, radio frequency identification, and near-field communication. In smart healthcare applications, designing ergonomic and intuitive human–computer interfaces is crucial because a system that is not easy to use will create a huge obstacle to adoption and may significantly reduce the efficacy of the solution. Signal and data processing is another important consideration in smart healthcare applications because it must ensure high accuracy with a high level of confidence in order for the applications to be useful for clinicians in making diagnosis and treatment decisions. This Special Issue is a collection of 10 articles selected from a total of 26 contributions. These contributions span the areas of signal processing and smart healthcare systems mostly contributed by authors from Europe, including Italy, Spain, France, Portugal, Romania, Sweden, and Netherlands. Authors from China, Korea, Taiwan, Indonesia, and Ecuador are also included

Energy-Efficient Recurrent Neural Network Accelerators for Real-Time Inference

Over the past decade, Deep Learning (DL) and Deep Neural Network (DNN) have gone through a rapid development. They are now vastly applied to various applications and have profoundly changed the life of hu- man beings. As an essential element of DNN, Recurrent Neural Networks (RNN) are helpful in processing time-sequential data and are widely used in applications such as speech recognition and machine translation. RNNs are difficult to compute because of their massive arithmetic operations and large memory footprint. RNN inference workloads used to be executed on conventional general-purpose processors including Central Processing Units (CPU) and Graphics Processing Units (GPU); however, they have un- necessary hardware blocks for RNN computation such as branch predictor, caching system, making them not optimal for RNN processing. To accelerate RNN computations and outperform the performance of conventional processors, previous work focused on optimization methods on both software and hardware. On the software side, previous works mainly used model compression to reduce the memory footprint and the arithmetic operations of RNNs. On the hardware side, previous works also designed domain-specific hardware accelerators based on Field Pro- grammable Gate Arrays (FPGA) or Application Specific Integrated Circuits (ASIC) with customized hardware pipelines optimized for efficient pro- cessing of RNNs. By following this software-hardware co-design strategy, previous works achieved at least 10X speedup over conventional processors. Many previous works focused on achieving high throughput with a large batch of input streams. However, in real-time applications, such as gaming Artificial Intellegence (AI), dynamical system control, low latency is more critical. Moreover, there is a trend of offloading neural network workloads to edge devices to provide a better user experience and privacy protection. Edge devices, such as mobile phones and wearable devices, are usually resource-constrained with a tight power budget. They require RNN hard- ware that is more energy-efficient to realize both low-latency inference and long battery life. Brain neurons have sparsity in both the spatial domain and time domain. Inspired by this human nature, previous work mainly explored model compression to induce spatial sparsity in RNNs. The delta network algorithm alternatively induces temporal sparsity in RNNs and can save over 10X arithmetic operations in RNNs proven by previous works. In this work, we have proposed customized hardware accelerators to exploit temporal sparsity in Gated Recurrent Unit (GRU)-RNNs and Long Short-Term Memory (LSTM)-RNNs to achieve energy-efficient real-time RNN inference. First, we have proposed DeltaRNN, the first-ever RNN accelerator to exploit temporal sparsity in GRU-RNNs. DeltaRNN has achieved 1.2 TOp/s effective throughput with a batch size of 1, which is 15X higher than its related works. Second, we have designed EdgeDRNN to accelerate GRU-RNN edge inference. Compared to DeltaRNN, EdgeDRNN does not rely on on-chip memory to store RNN weights and focuses on reducing off-chip Dynamic Random Access Memory (DRAM) data traffic using a more scalable architecture. EdgeDRNN have realized real-time inference of large GRU-RNNs with submillisecond latency and only 2.3 W wall plug power consumption, achieving 4X higher energy efficiency than commercial edge AI platforms like NVIDIA Jetson Nano. Third, we have used DeltaRNN to realize the first-ever continuous speech recognition sys- tem with the Dynamic Audio Sensor (DAS) as the front-end. The DAS is a neuromorphic event-driven sensor that produces a stream of asyn- chronous events instead of audio data sampled at a fixed sample rate. We have also showcased how an RNN accelerator can be integrated with an event-driven sensor on the same chip to realize ultra-low-power Keyword Spotting (KWS) on the extreme edge. Fourth, we have used EdgeDRNN to control a powered robotic prosthesis using an RNN controller to replace a conventional proportional–derivative (PD) controller. EdgeDRNN has achieved 21 μs latency of running the RNN controller and could maintain stable control of the prosthesis. We have used DeltaRNN and EdgeDRNN to solve these problems to prove their value in solving real-world problems. Finally, we have applied the delta network algorithm on LSTM-RNNs and have combined it with a customized structured pruning method, called Column-Balanced Targeted Dropout (CBTD), to induce spatio-temporal sparsity in LSTM-RNNs. Then, we have proposed another FPGA-based accelerator called Spartus, the first RNN accelerator that exploits spatio- temporal sparsity. Spartus achieved 9.4 TOp/s effective throughput with a batch size of 1, the highest among present FPGA-based RNN accelerators with a power budget around 10 W. Spartus can complete the inference of an LSTM layer having 5 million parameters within 1 μs

Development of a Limb prosthesis by reverse mechanotransduction

Recent developments in the field of limb prosthesis have focused on the use of body signals of the user to generate the desired motion in the prosthesis. Unlike earlier designs, this approach is more effective and less stressful for the amputee. The signals that have been used up till now are EMG signals, EEG signals and neural signals. Another possible source of body signal is the pH value of the neuromuscular junction, which depends upon the ion movements across the muscle tissue. Hence, it is safe to assume that changes in the pH can accurately mimic the intended changes in the amputated limb muscles, and therefore can be used to turn the user’s desired motion into actual motion of the limb prosthesis. In the current model, this is achieved through the means of a pH-to-voltage converter that converts the pH value into voltage that is in turn used to drive the motor. The direction of movement is controlled by a microcontroller-based circuit. Further improvements can be made upon the model presented in this thesis, if the pH values could be more accurately read and employed to determine the direction of the movement of the finger too. Also, attempts can be made to apply the same working principle on more complex models of hand prosthesis, thus producing more applicable results

ASSISTIVE DEVICE FOR LOWER EXTREMITY GAIT TRAINING AND ASSISTANCE

Ph.DDOCTOR OF PHILOSOPH

A pervasive body sensor network for monitoring post-operative recovery

Over the past decade, miniaturisation and cost reduction brought about by the semiconductor industry has led to computers smaller in size than a pin head, powerful enough to carry out the processing required, and affordable enough to be disposable. Similar technological advances in wireless communication, sensor design, and energy storage have resulted in the development of wireless “Body Sensor Network (BSN) platforms comprising of tiny integrated micro sensors with onboard processing and wireless data transfer capability, offering the prospect of pervasive and continuous home health monitoring. In surgery, the reduced trauma of minimally invasive interventions combined with initiatives to reduce length of hospital stay and a socioeconomic drive to reduce hospitalisation costs, have all resulted in a trend towards earlier discharge from hospital. There is now a real need for objective, pervasive, and continuous post-operative home recovery monitoring systems. Surgical recovery is a multi-faceted and dynamic process involving biological, physiological, functional, and psychological components. Functional recovery (physical independence, activities of daily living, and mobility) is recognised as a good global indicator of a patient’s post-operative course, but has traditionally been difficult to objectively quantify. This thesis outlines the development of a pervasive wireless BSN system to objectively monitor the functional recovery of post-operative patients at home. Biomechanical markers were identified as surrogate measures for activities of daily living and mobility impairment, and an ear-worn activity recognition (e-AR) sensor containing a three-axis accelerometer and a pulse oximeter was used to collect this data. A simulated home environment was created to test a Bayesian classifier framework with multivariate Gaussians to model activity classes. A real-time activity index was used to provide information on the intensity of activity being performed. Mobility impairment was simulated with bracing systems and a multiresolution wavelet analysis and margin-based feature selection framework was used to detect impaired mobility. The e-AR sensor was tested in a home environment before its clinical use in monitoring post-operative home recovery of real patients who have undergone surgery. Such a system may eventually form part of an objective pervasive home recovery monitoring system tailored to the needs of today’s post-operative patient.Open acces

Algorithms for information extraction and signal annotation on long-term biosignals using clustering techniques

Dissertação para obtenção do Grau de Mestre em Engenharia BiomédicaOne of the biggest challenges when analysing data is to extract information from it, especially if we dealing with very large sized data, which brings a new set of barriers to be overcome. The extracted information can be used to aid physicians in their diagnosis since biosignals often carry vital information on the subjects. In this research work, we present a signal-independent algorithm with two main goals: perform events detection in biosignals and, with those events, extract information using a set of distance measures which will be used as input to a parallel version of the k-means clustering algorithm. The first goal is achieved by using two different approaches. Events can be found based on peaks detection through an adaptive threshold defined as the signal’s root mean square (RMS) or by morphological analysis through the computation of the signal’s meanwave. The final goal is achieved by dividing the distance measures into n parts and by performing k-means individually. In order to improve speed performance, parallel computing techniques were applied. For this study, a set of different types of signals was acquired and annotated by our algorithm. By visual inspection, the L1 and L2 Minkowski distances returned an output that allowed clustering signals’ cycles with an efficiency of 97:5% and 97:3%, respectively. Using the meanwave distance, our algorithm achieved an accuracy of 97:4%. For the downloaded ECGs from the Physionet databases, the developed algorithm detected 638 out of 644 manually annotated events provided by physicians. The fact that this algorithm can be applied to long-term raw biosignals and without requiring any prior information about them makes it an important contribution in biosignals’ information extraction and annotation

Computational Intelligence in Electromyography Analysis

Electromyography (EMG) is a technique for evaluating and recording the electrical activity produced by skeletal muscles. EMG may be used clinically for the diagnosis of neuromuscular problems and for assessing biomechanical and motor control deficits and other functional disorders. Furthermore, it can be used as a control signal for interfacing with orthotic and/or prosthetic devices or other rehabilitation assists. This book presents an updated overview of signal processing applications and recent developments in EMG from a number of diverse aspects and various applications in clinical and experimental research. It will provide readers with a detailed introduction to EMG signal processing techniques and applications, while presenting several new results and explanation of existing algorithms. This book is organized into 18 chapters, covering the current theoretical and practical approaches of EMG research

Wearable Wireless Devices

No abstract available

Fused mechanomyography and inertial measurement for human-robot interface

Human-Machine Interfaces (HMI) are the technology through which we interact with the ever-increasing quantity of smart devices surrounding us. The fundamental goal of an HMI is to facilitate robot control through uniting a human operator as the supervisor with a machine as the task executor. Sensors, actuators, and onboard intelligence have not reached the point where robotic manipulators may function with complete autonomy and therefore some form of HMI is still necessary in unstructured environments. These may include environments where direct human action is undesirable or infeasible, and situations where a robot must assist and/or interface with people. Contemporary literature has introduced concepts such as body-worn mechanical devices, instrumented gloves, inertial or electromagnetic motion tracking sensors on the arms, head, or legs, electroencephalographic (EEG) brain activity sensors, electromyographic (EMG) muscular activity sensors and camera-based (vision) interfaces to recognize hand gestures and/or track arm motions for assessment of operator intent and generation of robotic control signals. While these developments offer a wealth of future potential their utility has been largely restricted to laboratory demonstrations in controlled environments due to issues such as lack of portability and robustness and an inability to extract operator intent for both arm and hand motion. Wearable physiological sensors hold particular promise for capture of human intent/command. EMG-based gesture recognition systems in particular have received significant attention in recent literature. As wearable pervasive devices, they offer benefits over camera or physical input systems in that they neither inhibit the user physically nor constrain the user to a location where the sensors are deployed. Despite these benefits, EMG alone has yet to demonstrate the capacity to recognize both gross movement (e.g. arm motion) and finer grasping (e.g. hand movement). As such, many researchers have proposed fusing muscle activity (EMG) and motion tracking e.g. (inertial measurement) to combine arm motion and grasp intent as HMI input for manipulator control. However, such work has arguably reached a plateau since EMG suffers from interference from environmental factors which cause signal degradation over time, demands an electrical connection with the skin, and has not demonstrated the capacity to function out of controlled environments for long periods of time. This thesis proposes a new form of gesture-based interface utilising a novel combination of inertial measurement units (IMUs) and mechanomyography sensors (MMGs). The modular system permits numerous configurations of IMU to derive body kinematics in real-time and uses this to convert arm movements into control signals. Additionally, bands containing six mechanomyography sensors were used to observe muscular contractions in the forearm which are generated using specific hand motions. This combination of continuous and discrete control signals allows a large variety of smart devices to be controlled. Several methods of pattern recognition were implemented to provide accurate decoding of the mechanomyographic information, including Linear Discriminant Analysis and Support Vector Machines. Based on these techniques, accuracies of 94.5% and 94.6% respectively were achieved for 12 gesture classification. In real-time tests, accuracies of 95.6% were achieved in 5 gesture classification. It has previously been noted that MMG sensors are susceptible to motion induced interference. The thesis also established that arm pose also changes the measured signal. This thesis introduces a new method of fusing of IMU and MMG to provide a classification that is robust to both of these sources of interference. Additionally, an improvement in orientation estimation, and a new orientation estimation algorithm are proposed. These improvements to the robustness of the system provide the first solution that is able to reliably track both motion and muscle activity for extended periods of time for HMI outside a clinical environment. Application in robot teleoperation in both real-world and virtual environments were explored. With multiple degrees of freedom, robot teleoperation provides an ideal test platform for HMI devices, since it requires a combination of continuous and discrete control signals. The field of prosthetics also represents a unique challenge for HMI applications. In an ideal situation, the sensor suite should be capable of detecting the muscular activity in the residual limb which is naturally indicative of intent to perform a specific hand pose and trigger this post in the prosthetic device. Dynamic environmental conditions within a socket such as skin impedance have delayed the translation of gesture control systems into prosthetic devices, however mechanomyography sensors are unaffected by such issues. There is huge potential for a system like this to be utilised as a controller as ubiquitous computing systems become more prevalent, and as the desire for a simple, universal interface increases. Such systems have the potential to impact significantly on the quality of life of prosthetic users and others.Open Acces