Large-scale Foundation Models and Generative AI for BigData Neuroscience

Recent advances in machine learning have made revolutionary breakthroughs in computer games, image and natural language understanding, and scientific discovery. Foundation models and large-scale language models (LLMs) have recently achieved human-like intelligence thanks to BigData. With the help of self-supervised learning (SSL) and transfer learning, these models may potentially reshape the landscapes of neuroscience research and make a significant impact on the future. Here we present a mini-review on recent advances in foundation models and generative AI models as well as their applications in neuroscience, including natural language and speech, semantic memory, brain-machine interfaces (BMIs), and data augmentation. We argue that this paradigm-shift framework will open new avenues for many neuroscience research directions and discuss the accompanying challenges and opportunities

Advances in Neural Signal Processing

Neural signal processing is a specialized area of signal processing aimed at extracting information or decoding intent from neural signals recorded from the central or peripheral nervous system. This has significant applications in the areas of neuroscience and neural engineering. These applications are famously known in the area of brain–machine interfaces. This book presents recent advances in this flourishing field of neural signal processing with demonstrative applications

Advances in Neural Signal Processing

Neural signal processing is a specialized area of signal processing aimed at extracting information or decoding intent from neural signals recorded from the central or peripheral nervous system. This has significant applications in the areas of neuroscience and neural engineering. These applications are famously known in the area of brain–machine interfaces. This book presents recent advances in this flourishing field of neural signal processing with demonstrative applications

Advances in Neural Signal Processing

Neural signal processing is a specialized area of signal processing aimed at extracting information or decoding intent from neural signals recorded from the central or peripheral nervous system. This has significant applications in the areas of neuroscience and neural engineering. These applications are famously known in the area of brain–machine interfaces. This book presents recent advances in this flourishing field of neural signal processing with demonstrative applications

Closed-loop experiments and brain machine interfaces with multiphoton microscopy

In the field of neuroscience, the importance of constructing closed-loop experimental systems has increased in conjunction with technological advances in measuring and controlling neural activity in live animals. This paper provides an overview of recent technological advances in the field, focusing on closed-loop experimental systems where multiphoton microscopy (the only method capable of recording and controlling targeted population activity of neurons at a single-cell resolution in vivo) works through real-time feedback. Specifically, we present some examples of brain machine interfaces (BMIs) using in vivo two-photon calcium imaging and discuss applications of two-photon optogenetic stimulation and adaptive optics to real-time BMIs. We also consider conditions for realizing future optical BMIs at the synaptic level, and their possible roles in understanding the computational principles of the brain

Modern Tools for Noninvasive Analysis of Brainwaves: Applications in Assistive Technologies and Medical Diagnostics

Advances in Biomaterials and Medical Devices PanelDigital signal processing is arguably one of the most important segments of any modern medical equipment. Recent advances in intelligence signal processing have married machine learning methods to traditional signal analysis and classification practices. In this talk, I will review state of the art brainwave analysis methods and our related advances in quantitative electroencephalogram (qEEG) analysis for brain computer interfaces (thought translation devices), as well as cerebral ischemia localization (e.g. for clamp monitoring during inetroperative carotid endarterectomy). The presentation will conclude with a discussion on corresponding R&D trends, especially near infrared spectroscopy (NIRS) as a new complementary modality to EEG for portable and affordable monitoring of brain functions

A Neuromorphic Prosthesis to Restore Communication in Neuronal Networks

Recent advances in bioelectronics and neural engineering allowed the development of brain machine interfaces and neuroprostheses, capable of facilitating or recovering functionality in people with neurological disability. To realize energy-efficient and real-time capable devices, neuromorphic computing systems are envisaged as the core of next-generation systems for brain repair. We demonstrate here a real-time hardware neuromorphic prosthesis to restore bidirectional interactions between two neuronal populations, even when one is damaged or missing. We used in vitro modular cell cultures to mimic the mutual interaction between neuronal assemblies and created a focal lesion to functionally disconnect the two populations. Then, we employed our neuromorphic prosthesis for bidirectional bridging to artificially reconnect two disconnected neuronal modules and for hybrid bidirectional bridging to replace the activity of one module with a real-time hardware neuromorphic Spiking Neural Network. Our neuroprosthetic system opens avenues for the exploitation of neuromorphic-based devices in bioelectrical therapeutics for health care

Reinventing Ourselves: The Plasticity of Embodiment, Sensing, and Mind

Recent advances in Cognitive Science and Cognitive Neuroscience open up new vistas for human enhancement. Central to much of this work is the idea of new Human-Machine interfaces (in general) and new Brain-Machine interfaces (in particular). But despite the increasing prominence of such ideas, the very idea of such an interface remains surprisingly under-explored. In particular, the notion of human enhancement suggests an image of the embodied and reasoning agent as literally extended or augmented, rather than the more conservative image of a standard (non-enhanced) agent using a tool via some new interface. In this essay, I explore this difference, and attempt to lay out some of the conditions under which the more radical reading (positing brand new integrated agents or systemic wholes) becomes justified

Recent and upcoming BCI progress: overview, analysis, and recommendations

Brain–computer interfaces (BCIs) are finally moving out of the laboratory and beginning to gain acceptance in real-world situations. As BCIs gain attention with broader groups of users, including persons with different disabilities and healthy users, numerous practical questions gain importance. What are the most practical ways to detect and analyze brain activity in field settings? Which devices and applications are most useful for different people? How can we make BCIs more natural and sensitive, and how can BCI technologies improve usability? What are some general trends and issues, such as combining different BCIs or assessing and comparing performance? This book chapter provides an overview of the different sections of this book, providing a summary of how authors address these and other questions. We also present some predictions and recommendations that ensue from our experience from discussing these and other issues with our authors and other researchers and developers within the BCI community. We conclude that, although some directions are hard to predict, the field is definitely growing and changing rapidly, and will continue doing so in the next several years