Enviromental standards and costly monitoring.

In this paper, we investigate the features of an optimal regulatory policy composed of pollution standards and probabilities of inspection to verify firms' behavior, where fines for noncompliance depend on the degree of violation. We find that the optimal policy can entail either compliance or noncompliance with the enviromental standards, the latter being more plausible when monitoring costs are high and, surprisingly, when fines for noncompliance are also high. In the event the planner has perfect information about the firns, we find that, whe the optimal policy entails noncompliance, the optimal standard is always equal to zero, suggesting the superiority of probabilistic environmental taxes versus positive standards. However this is no longer true when the planner has incomplete information about the regulated agents.standard-setting; costly inspection; convex fines;

Litigation-Ending Sanctions: Alaska Courts’ Use of Rule 37

Pain is a common symptom of a number of conditions including cancer and one of the most frequent reasons for seeking healthcare. Acute and chronic pain result in considerable discomfort with a detrimental impact on the quality of life. Opioids are the mainstay of pain management for many patients with severe pain. Opioids are, unfortunately, also commonly abused drugs, and are well-represented in forensic toxicology investigations. Side effects related to the central nervous system are the major reasons fordiscontinuation of opioid treatment. In this thesis, we tested the hypothesis that local analgesic treatment by opioids, without the usual opioid-related side effects, could be a potential alternative to systemic opioid treatment. We examined the analgesic effect of topically applied morphine in a randomized, double blind, cross over study in patients with painful leg ulcers. Significant reduction of pain was obtained after application of both morphine and placebo gel. Morphine reduced pain more than placebo but the difference was not statistically significant. However, morphine could reduce pain considerably more than placebo in those cases where VAS (Visual analog scale) was higher initially. Another issue with opioid therapy is the substantial individual variability in response to opioids including morphine and tramadol. We investigated the significance of UGT2B7, CYP2D6, OPRM1 and ABCB1 polymorphisms for pharmacokinetic and pharmacodynamic properties of morphine and tramadol. We showed that genetic variants in CYP2D6 and UGT2B7 have an important role in the metabolism of tramadol and morphine respectively. While the role of SNPs in ABCB1 remained unclear, genetic variants in OPRM1 gene were correlated with the required dose of morphine. Taken together, these findings suggest that genotypes should be taken into consideration when interpreting clinical pharmacology and forensic toxicology results. Opioids, besides their analgesic properties, have other pharmacological effects including effects on immune system. We evaluated potential differences between commonly used opiates with regard to their effect on the immune system. We found an inhibition of cytokine release, in the order of potency as follows: tramadol &gt; ketobemidone &gt;morphine &gt;fentanyl. All opioids with the exception of fentanyl were capable of inhibiting production of mRNAs for TNF-alpha and IL-8. Further studies are needed to understand the clinical implications of the observed immunosuppressive effects of opioids and to improve opioid treatment strategies in patients with cancer. Here, we have found that individual genotype matters and affects the individual response. Further research is warranted to tailor individualized treatment. Personalized medicine has increased in importance and will hopefully in the near future become standard procedure to improve and predict the outcome of treatment by opioids.The series name in the title page is incorret. The correct title should be Linköping University Medical Dissertations.</p

Lady Justice Cannot Hear Your Prayers

The Islamic finance industry continues to grow quickly as the appetite for everything, from Sharia-compliant home mortgages and car loans to sophisticated financial products, increases. This growth has triggered an interest in sukuk, bond-like financial instruments. And while the international market for sukuk has long been dominated by foreign issuers and English law, the attraction of a niche market compatible with U.S. federal and international securities laws may propel increased participation by U.S. issuers and investors who wish to transact under U.S. federal and state laws. As with all Islamic financial products, sukuk transactions inherently pose a Sharia compliance risk. Thus far, religious compliance has not posed a significant barrier to the international market given that most sukuk transactions are governed by secular laws that incorporate Sharia law or laws that are not averse to interpreting religious law. U.S. jurisprudence, however, has strongly avoided religious questions that would require courts to interpret religious doctrines. While the application of the religious question doctrine helps maintain the separation of church and state, it can withhold secular judicial remedies from parties to a commercial agreement that incorporates religious tenets, such as a sukuk transaction. Drawing upon the example of Dana Gas PJSC, a company that sued to have its own sukuk certificates declared invalid and related payment obligations declared unenforceable due to the transaction’s alleged noncompliance with Sharia law, this Note explores the Establishment Clause obstacles to adjudication of a similar claim under New York law. Ultimately, this Note concludes that the Establishment Clause bars adjudication of the merits of such a dispute and proposes the adoption of legislation, at the state and federal level, that would permit secular courts to “certify” religious questions to party-selected religious tribunals. Pending passage of such litigation, commercial parties are encouraged to utilize alternative dispute resolution

Towards a Semantic-based Approach for Modeling Regulatory Documents in Building Industry

Regulations in the Building Industry are becoming increasingly complex and involve more than one technical area. They cover products, components and project implementation. They also play an important role to ensure the quality of a building, and to minimize its environmental impact. In this paper, we are particularly interested in the modeling of the regulatory constraints derived from the Technical Guides issued by CSTB and used to validate Technical Assessments. We first describe our approach for modeling regulatory constraints in the SBVR language, and formalizing them in the SPARQL language. Second, we describe how we model the processes of compliance checking described in the CSTB Technical Guides. Third, we show how we implement these processes to assist industrials in drafting Technical Documents in order to acquire a Technical Assessment; a compliance report is automatically generated to explain the compliance or noncompliance of this Technical Documents

Rationalizing Racism: Arizona Representatives Employment of Euphemisms for an Assault on Mexican American Studies

This study details the political climate and logic priming the termination of Mexican American Studies in elementary and high school programs within the state of Arizona. The author applies conceptual content analysis and intertextuality to decode euphemisms incorporated by opponents of the program. Primary sources by the state’s Attorney General Tom Horne and school board Superintendent of Public Instruction John Huppenthal are examined for rationales used in the elimination of a pedagogically empowering program for Latina/o students within Tucson Unified School District. Repetitive paradoxes in arguments against Mexican American Studies are found to have implicitly formed a threat to the majority. Reasoning in public statements by the aforementioned politicians and frames for discussion of the program are concluded to have appealed to mainstream audiences as a decoy from alternative motives of maintaining current power structures with Latina/os subjugated to lower socio-economic statuses compared to White counterparts

Risk Aversion and Compliance in Markets for Pollution Control

This paper examines the effects of risk aversion on compliance choices in markets for pollution control. A firm’s decision to be compliant or not is independent of its manager’s risk preference. However, noncompliant firms with risk averse managers will have lower violations than otherwise identical firms with risk neutral managers. The violations of noncompliant firms with risk averse managers are independent of differences in their benefits from emissions and their initial allocations of permits if and only if their managers’ utility functions exhibit constant absolute risk aversion. However, firm-level characteristics do impact violation choices when managers have coefficients of absolute risk aversion that are increasing or decreasing in profit levels. Finally, in the equilibrium of a market for emissions rights with widespread noncompliance, risk aversion is associated with higher permit prices, better environmental quality, and lower aggregate violations.Emissions Trading, Compliance, Enforcement, Risk Aversion