Developments in the tools and methodologies of synthetic biology.

Synthetic biology is principally concerned with the rational design and engineering of biologically based parts, devices, or systems. However, biological systems are generally complex and unpredictable, and are therefore, intrinsically difficult to engineer. In order to address these fundamental challenges, synthetic biology is aiming to unify a body of knowledge from several foundational scientific fields, within the context of a set of engineering principles. This shift in perspective is enabling synthetic biologists to address complexity, such that robust biological systems can be designed, assembled, and tested as part of a biological design cycle. The design cycle takes a forward-design approach in which a biological system is specified, modeled, analyzed, assembled, and its functionality tested. At each stage of the design cycle, an expanding repertoire of tools is being developed. In this review, we highlight several of these tools in terms of their applications and benefits to the synthetic biology community

Space robotics: Recent accomplishments and opportunities for future research

The Langley Guidance, Navigation, and Control Technical Committee (GNCTC) was one of six technical committees created in 1991 by the Chief Scientist, Dr. Michael F. Card. During the kickoff meeting Dr. Card charged the chairmen to: (1) establish a cross-Center committee; (2) support at least one workshop in a selected discipline; and (3) prepare a technical paper on recent accomplishments in the discipline and on opportunities for future research. The Guidance, Navigation, and Control Committee was formed and selected for focus on the discipline of Space robotics. This report is a summary of the committee's assessment of recent accomplishments and opportunities for future research. The report is organized as follows. First is an overview of the data sources used by the committee. Next is a description of technical needs identified by the committee followed by recent accomplishments. Opportunities for future research ends the main body of the report. It includes the primary recommendation of the committee that NASA establish a national space facility for the development of space automation and robotics, one element of which is a telerobotic research platform in space. References 1 and 2 are the proceedings of two workshops sponsored by the committee during its June 1991, through May 1992 term. The focus of the committee for the June 1992 - May 1993 term will be to further define to the recommended platform in space and to add an additional discipline which includes aircraft related GN&C issues. To the latter end members performing aircraft related research will be added to the committee. (A preliminary assessment of future opportunities in aircraft-related GN&C research has been included as appendix A.

Distributed intelligent control and management (DICAM) applications and support for semi-automated development

We have recently begun a 4-year effort to develop a new technology foundation and associated methodology for the rapid development of high-performance intelligent controllers. Our objective in this work is to enable system developers to create effective real-time systems for control of multiple, coordinated entities in much less time than is currently required. Our technical strategy for achieving this objective is like that in other domain-specific software efforts: analyze the domain and task underlying effective performance, construct parametric or model-based generic components and overall solutions to the task, and provide excellent means for specifying, selecting, tailoring or automatically generating the solution elements particularly appropriate for the problem at hand. In this paper, we first present our specific domain focus, briefly describe the methodology and environment we are developing to provide a more regular approach to software development, and then later describe the issues this raises for the research community and this specific workshop

Combining a hierarchical task network planner with a constraint satisfaction solver for assembly operations involving routing problems in a multi-robot context

This work addresses the combination of a symbolic hierarchical task network planner and a constraint satisfaction solver for the vehicle routing problem in a multi-robot context for structure assembly operations. Each planner has its own problem domain and search space, and the article describes how both planners interact in a loop sharing information in order to improve the cost of the solutions. The vehicle routing problem solver gives an initial assignment of parts to robots, making the distribution based on the distance among parts and robots, trying also to maximize the parallelism of the future assembly operations evaluating during the process the dependencies among the parts assigned to each robot. Then, the hierarchical task network planner computes a scheduling for the given assignment and estimates the cost in terms of time spent on the structure assembly. This cost value is then given back to the vehicle routing problem solver as feedback to compute a better assignment, closing the loop and repeating again the whole process. This interaction scheme has been tested with different constraint satisfaction solvers for the vehicle routing problem. The article presents simulation results in a scenario with a team of aerial robots assembling a structure, comparing the results obtained with different configurations of the vehicle routing problem solver and showing the suitability of using this approach.Unión Europea ARCAS FP7-ICT-287617Unión Europea H2020-ICT-644271Unión europea H2020-ICT-73166

Applying semantic web services to enterprise web

Enterprise Web provides a convenient, extendable, integrated platform for information sharing and knowledge management. However, it still has many drawbacks due to complexity and increasing information glut, as well as the heterogeneity of the information processed. Research in the field of Semantic Web Services has shown the possibility of adding higher level of semantic functionality onto the top of current Enterprise Web, enhancing usability and usefulness of resource, enabling decision support and automation. This paper aims to explore the use of Semantic Web Services in Enterprise Web and discuss the Semantic Web Services (SWS) approach for designing Enterprise Web applications. A Semantic Web Service oriented model is presented, in which resources and services are described by ontology, and processed through Semantic Web Service, allowing integrated administration, interoperability and automated reasoning

Utilizing a 3D game engine to develop a virtual design review system

A design review process is where information is exchanged between the designers and design reviewers to resolve any potential design related issues, and to ensure that the interests and goals of the owner are met. The effective execution of design review will minimize potential errors or conflicts, reduce the time for review, shorten the project life-cycle, allow for earlier occupancy, and ultimately translate into significant total project savings to the owner. However, the current methods of design review are still heavily relying on 2D paper-based format, sequential and lack central and integrated information base for efficient exchange and flow of information. There is thus a need for the use of a new medium that allow for 3D visualization of designs, collaboration among designers and design reviewers, and early and easy access to design review information. This paper documents the innovative utilization of a 3D game engine, the Torque Game Engine as the underlying tool and enabling technology for a design review system, the Virtual Design Review System for architectural designs. Two major elements are incorporated; 1) a 3D game engine as the driving tool for the development and implementation of design review processes, and 2) a virtual environment as the medium for design review, where visualization of design and design review information is based on sound principles of GUI design. The development of the VDRS involves two major phases; firstly, the creation of the assets and the assembly of the virtual environment, and secondly, the modification of existing functions or introducing new functionality through programming of the 3D game engine in order to support design review in a virtual environment. The features that are included in the VDRS are support for database, real-time collaboration across network, viewing and navigation modes, 3D object manipulation, parametric input, GUI, and organization for 3D objects