Open Source EEG Platform with Reconfigurable Features for Multiple-Scenarios

Electroencephalogram (EEG) acquisition systems are widely used as diagnostic and research tools. This document shows the implementation of a reconfigurable family of three affordable 8-channels, 24 bits of resolution, EEG acquisition systems intended for a wide variety of research purposes. The three devices offer a modular design and upgradability, permitting changes in the firmware and software. Due to the nature of the Analog Front-End (AFE) used, no high-pass analog filters were implemented, allowing the capture of very low frequency components. Two systems of the family, called “RF-Brain” and “Bluetooth-Brain”, were designed to be light and wireless, planned for experimentation where movement of the subject cannot be restricted. The sample rate in these systems can be configured up to 2000 samples per second (SPS) for the RF-Brain and 250 SPS for the Bluetooth-Brain when the 8 channels are used. If fewer channels are required, the sampling frequency can be higher (up to 4 kSPS or 2 kSPS for 1 channel for RF-Brain and Bluetooth-Brain respectively). The third system, named “USB-Brain”, is a wired device designed for purposes requiring high sampling frequency acquisition and general purpose ports, with sampling rates up to 4 kSPS

Regression Based Continuous Driving Fatigue Estimation: Towards Practical Implementation

Mental fatigue in drivers is one of the leading causes that give rise to traffic accidents. Electroencephalography (EEG) based driving fatigue studies showed promising performance in fatigue monitoring. However, complex methodologies are not suitable for practical implementation. In our simulation based setup that retained the constraints of real driving, we took a step closer to fatigue estimation in a practical scenario. We adopted a pre-processing pipeline with low computational complexity, which can be easily and practically implemented in real-time. Moreover, regression-based continuous fatigue estimation was achieved using power spectral features in conjunction with time as the fatigue label. We sought to compare three regression models and three time windows to demonstrate their effects on the performance of fatigue estimation. Dynamic time warping was proposed as a new measure for evaluating the performance of fatigue estimation. The results derived from the validation of the proposed framework on 19 subjects showed that our proposed framework was promising towards practical implementation. Fatigue estimation by the support vector regression with radial basis function kernel and 5-second window length achieved the best performance. We also provided a comprehensive analysis on the spatial distribution of channels and frequency bands mostly contributing to fatigue estimation, which can inform the feature and channel reduction for real-time fatigue monitoring in practical driving. After reducing the number of electrodes by 75%, the proposed framework retained comparable performance in fatigue estimation. This study demonstrates the feasibility and adaptability of our proposed framework in practical implementation of mental fatigue estimation

Wireless Implantable ICs for Energy-Efficient Long-Term Ambulatory EEG Monitoring

This thesis presents the design, development, and experimental characterization of wireless subcutaneous implantable integrated circuits and systems for long-term ambulatory EEG monitoring. Application-, system- and circuit-level requirements for such a device are discussed and a critical review of the state-of-the-art academic and currently available commercial solutions are provided. Two prototypes are presented: The first prototype presented in Chapter 2 is an 8-channel wireless implantable device with a 2.5×1.5 mm2 custom-designed integrated circuit implemented using CMOS 180nm technology at its core. The microchip is fabricated and the measurement results showing its efficacy in EEG signal recording in terms of input-referred noise, voltage gain, signal-to-noise ratio, and power consumption are presented. The chip is implemented together with a BLE 5.0 module on the same platform. Our vision and discussions on biocompatible encapsulation of this system, as well as its integration with a microelectrode array as also provided. The second prototype, also implemented in CMOS 180nm technology and presented in Chapter 3, employs a novel EEG recording channel architecture that enables long-term implantation of EEG monitoring devices through significant improvement of their energy efficiency. The channel leverages the inherent sparsity of the EEG signals and conducts recording in an activity-dependent adaptive manner. Thanks to the proposed fully dynamic spectral-compressing architecture, the recording channels power consumption is drastically reduced. More importantly, the proposed architecture reduces the required wireless transmission throughput by more than an order of magnitude. Our test results on 10 different patients’ pre-recorded human EEG data shows an average of 12.6× improvement in the device’s energy efficiency

Real-time assessment of vigilance level using an innovative Mindo4 wireless EEG system

Monitoring the neurophysiological activities of driver in an operational environment poses a severe measurement challenge using a current laboratory-oriented biosensor technology. The aims of this research are to 1) introduce a dry and wireless EEG system used for conveniently recording EEG signals from forehead regions, 2) propose an effective system for processing EEG recordings and translating them into the vigilance level, and 3) implement the proposed system with a JAVA-based graphical user interface (GUI) for online analysis. To validate the performance of the proposed system, this study recruited eight voluntary subjects to participate a 90-min sustained-attention driving task in a virtual-realistic driving environment. Physiological evidence obtained from the power spectral analysis showed that the dry EEG system could distinguish an alert EEG from a drowsy EEG by evaluating the spectral dynamics of delta and alpha activities. Furthermore, the experimental result of the comparison of the prediction performance using four forehead electrode sites (AF8, FP2, FP1, and AF7) implied that a single-electrode EEG signal used in the mobile and wireless EEG system is able to obtain a high prediction accuracy (∼93%). Taken together, the proposed system applied a dry-EEG device combined with an effective algorithm can be a promising technology for real driving applications. © 2013 IEEE