Machine Learning Methods for Image Analysis in Medical Applications, from Alzheimer\u27s Disease, Brain Tumors, to Assisted Living

Healthcare has progressed greatly nowadays owing to technological advances, where machine learning plays an important role in processing and analyzing a large amount of medical data. This thesis investigates four healthcare-related issues (Alzheimer\u27s disease detection, glioma classification, human fall detection, and obstacle avoidance in prosthetic vision), where the underlying methodologies are associated with machine learning and computer vision. For Alzheimer’s disease (AD) diagnosis, apart from symptoms of patients, Magnetic Resonance Images (MRIs) also play an important role. Inspired by the success of deep learning, a new multi-stream multi-scale Convolutional Neural Network (CNN) architecture is proposed for AD detection from MRIs, where AD features are characterized in both the tissue level and the scale level for improved feature learning. Good classification performance is obtained for AD/NC (normal control) classification with test accuracy 94.74%. In glioma subtype classification, biopsies are usually needed for determining different molecular-based glioma subtypes. We investigate non-invasive glioma subtype prediction from MRIs by using deep learning. A 2D multi-stream CNN architecture is used to learn the features of gliomas from multi-modal MRIs, where the training dataset is enlarged with synthetic brain MRIs generated by pairwise Generative Adversarial Networks (GANs). Test accuracy 88.82% has been achieved for IDH mutation (a molecular-based subtype) prediction. A new deep semi-supervised learning method is also proposed to tackle the problem of missing molecular-related labels in training datasets for improving the performance of glioma classification. In other two applications, we also address video-based human fall detection by using co-saliency-enhanced Recurrent Convolutional Networks (RCNs), as well as obstacle avoidance in prosthetic vision by characterizing obstacle-related video features using a Spiking Neural Network (SNN). These investigations can benefit future research, where artificial intelligence/deep learning may open a new way for real medical applications

Introspective Perception for Mobile Robots

Perception algorithms that provide estimates of their uncertainty are crucial to the development of autonomous robots that can operate in challenging and uncontrolled environments. Such perception algorithms provide the means for having risk-aware robots that reason about the probability of successfully completing a task when planning. There exist perception algorithms that come with models of their uncertainty; however, these models are often developed with assumptions, such as perfect data associations, that do not hold in the real world. Hence the resultant estimated uncertainty is a weak lower bound. To tackle this problem we present introspective perception - a novel approach for predicting accurate estimates of the uncertainty of perception algorithms deployed on mobile robots. By exploiting sensing redundancy and consistency constraints naturally present in the data collected by a mobile robot, introspective perception learns an empirical model of the error distribution of perception algorithms in the deployment environment and in an autonomously supervised manner. In this paper, we present the general theory of introspective perception and demonstrate successful implementations for two different perception tasks. We provide empirical results on challenging real-robot data for introspective stereo depth estimation and introspective visual simultaneous localization and mapping and show that they learn to predict their uncertainty with high accuracy and leverage this information to significantly reduce state estimation errors for an autonomous mobile robot

Selection of critical nodes in drone airways graphs via graph neural networks

This Master Thesis has two distinct parts. The first one mod- els an application of Graph Neural Networks (GNN) for the identifica- tion of critical nodes in graphs that correspond to traffic networks. We call critical nodes those that can compromise the traffic flow in some subgraphs of the network. Specifically, the example data for the demon- stration corresponds to the Vienna subway network, hence the linear subgraphs correspond to the subway lines with intersections at some key subway stations. Those critical nodes relative to a subway line compro- mise the traffic flow at this line, therefore, we propose three GNN based approaches for the identification of such critical nodes, reporting encour- aging results. The second part of the Master Thesis illustrates the back- ground research work on drone airspace management and a discussion of how the reported results may have some relevance for this emerging dif- ficult problem. The main idea is that the urban airspace for drones, that may be carrying out delivery of either persons (aerotaxis) or goods, can be structured along airways that mimic the existing network of streets. The computational example explored in part one of the Master Thesis, thus, becomes relevant for the development of intelligent drone airspace management

A survey of deep learning models in medical therapeutic areas.

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