110,350 research outputs found
Detection of atrial fibrillation episodes in long-term heart rhythm signals using a support vector machine
Atrial fibrillation (AF) is a serious heart arrhythmia leading to a significant increase of the risk for occurrence of ischemic stroke. Clinically, the AF episode is recognized in an electrocardiogram. However, detection of asymptomatic AF, which requires a long-term monitoring, is more efficient when based on irregularity of beat-to-beat intervals estimated by the heart rate (HR) features. Automated classification of heartbeats into AF and non-AF by means of the Lagrangian Support Vector Machine has been proposed. The classifier input vector consisted of sixteen features, including four coefficients very sensitive to beat-to-beat heart changes, taken from the fetal heart rate analysis in perinatal medicine. Effectiveness of the proposed classifier has been verified on the MIT-BIH Atrial Fibrillation Database. Designing of the LSVM classifier using very large number of feature vectors requires extreme computational efforts. Therefore, an original approach has been proposed to determine a training set of the smallest possible size that still would guarantee a high quality of AF detection. It enables to obtain satisfactory results using only 1.39% of all heartbeats as the training data. Post-processing stage based on aggregation of classified heartbeats into AF episodes has been applied to provide more reliable information on patient risk. Results obtained during the testing phase showed the sensitivity of 98.94%, positive predictive value of 98.39%, and classification accuracy of 98.86%.Web of Science203art. no. 76
Fully-Automatic Multiresolution Idealization for Filtered Ion Channel Recordings: Flickering Event Detection
We propose a new model-free segmentation method, JULES, which combines recent
statistical multiresolution techniques with local deconvolution for
idealization of ion channel recordings. The multiresolution criterion takes
into account scales down to the sampling rate enabling the detection of
flickering events, i.e., events on small temporal scales, even below the filter
frequency. For such small scales the deconvolution step allows for a precise
determination of dwell times and, in particular, of amplitude levels, a task
which is not possible with common thresholding methods. This is confirmed
theoretically and in a comprehensive simulation study. In addition, JULES can
be applied as a preprocessing method for a refined hidden Markov analysis. Our
new methodolodgy allows us to show that gramicidin A flickering events have the
same amplitude as the slow gating events. JULES is available as an R function
jules in the package clampSeg
Improved Stack-Slide Searches for Gravitational-Wave Pulsars
We formulate and optimize a computational search strategy for detecting
gravitational waves from isolated, previously-unknown neutron stars (that is,
neutron stars with unknown sky positions, spin frequencies, and spin-down
parameters). It is well known that fully coherent searches over the relevant
parameter-space volumes are not computationally feasible, and so more
computationally efficient methods are called for. The first step in this
direction was taken by Brady & Creighton (2000), who proposed and optimized a
two-stage, stack-slide search algorithm. We generalize and otherwise improve
upon the Brady-Creighton scheme in several ways. Like Brady & Creighton, we
consider a stack-slide scheme, but here with an arbitrary number of
semi-coherent stages and with a coherent follow-up stage at the end. We find
that searches with three semi-coherent stages are significantly more efficient
than two-stage searches (requiring about 2-5 times less computational power for
the same sensitivity) and are only slightly less efficient than searches with
four or more stages. We calculate the signal-to-noise ratio required for
detection, as a function of computing power and neutron star spin-down-age,
using our optimized searches.Comment: 19 pages, 7 figures, RevTeX
Time-frequency detection algorithm for gravitational wave bursts
An efficient algorithm is presented for the identification of short bursts of
gravitational radiation in the data from broad-band interferometric detectors.
The algorithm consists of three steps: pixels of the time-frequency
representation of the data that have power above a fixed threshold are first
identified. Clusters of such pixels that conform to a set of rules on their
size and their proximity to other clusters are formed, and a final threshold is
applied on the power integrated over all pixels in such clusters. Formal
arguments are given to support the conjecture that this algorithm is very
efficient for a wide class of signals. A precise model for the false alarm rate
of this algorithm is presented, and it is shown using a number of
representative numerical simulations to be accurate at the 1% level for most
values of the parameters, with maximal error around 10%.Comment: 26 pages, 15 figures, to appear in PR
Inpainting of long audio segments with similarity graphs
We present a novel method for the compensation of long duration data loss in
audio signals, in particular music. The concealment of such signal defects is
based on a graph that encodes signal structure in terms of time-persistent
spectral similarity. A suitable candidate segment for the substitution of the
lost content is proposed by an intuitive optimization scheme and smoothly
inserted into the gap, i.e. the lost or distorted signal region. Extensive
listening tests show that the proposed algorithm provides highly promising
results when applied to a variety of real-world music signals
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