Non Invasive Tools for Early Detection of Autism Spectrum Disorders

Autism Spectrum Disorders (ASDs) describe a set of neurodevelopmental disorders. ASD represents a significant public health problem. Currently, ASDs are not diagnosed before the 2nd year of life but an early identification of ASDs would be crucial as interventions are much more effective than specific therapies starting in later childhood. To this aim, cheap an contact-less automatic approaches recently aroused great clinical interest. Among them, the cry and the movements of the newborn, both involving the central nervous system, are proposed as possible indicators of neurological disorders. This PhD work is a first step towards solving this challenging problem. An integrated system is presented enabling the recording of audio (crying) and video (movements) data of the newborn, their automatic analysis with innovative techniques for the extraction of clinically relevant parameters and their classification with data mining techniques. New robust algorithms were developed for the selection of the voiced parts of the cry signal, the estimation of acoustic parameters based on the wavelet transform and the analysis of the infant’s general movements (GMs) through a new body model for segmentation and 2D reconstruction. In addition to a thorough literature review this thesis presents the state of the art on these topics that shows that no studies exist concerning normative ranges for newborn infant cry in the first 6 months of life nor the correlation between cry and movements. Through the new automatic methods a population of control infants (“low-risk”, LR) was compared to a group of “high-risk” (HR) infants, i.e. siblings of children already diagnosed with ASD. A subset of LR infants clinically diagnosed as newborns with Typical Development (TD) and one affected by ASD were compared. The results show that the selected acoustic parameters allow good differentiation between the two groups. This result provides new perspectives both diagnostic and therapeutic

MLGaze: Machine Learning-Based Analysis of Gaze Error Patterns in Consumer Eye Tracking Systems

Analyzing the gaze accuracy characteristics of an eye tracker is a critical task as its gaze data is frequently affected by non-ideal operating conditions in various consumer eye tracking applications. In this study, gaze error patterns produced by a commercial eye tracking device were studied with the help of machine learning algorithms, such as classifiers and regression models. Gaze data were collected from a group of participants under multiple conditions that commonly affect eye trackers operating on desktop and handheld platforms. These conditions (referred here as error sources) include user distance, head pose, and eye-tracker pose variations, and the collected gaze data were used to train the classifier and regression models. It was seen that while the impact of the different error sources on gaze data characteristics were nearly impossible to distinguish by visual inspection or from data statistics, machine learning models were successful in identifying the impact of the different error sources and predicting the variability in gaze error levels due to these conditions. The objective of this study was to investigate the efficacy of machine learning methods towards the detection and prediction of gaze error patterns, which would enable an in-depth understanding of the data quality and reliability of eye trackers under unconstrained operating conditions. Coding resources for all the machine learning methods adopted in this study were included in an open repository named MLGaze to allow researchers to replicate the principles presented here using data from their own eye trackers.Comment: https://github.com/anuradhakar49/MLGaz

A Clustering Approach for Autism based Autistic Trait Classification

Machine learning (ML) techniques can be utilized by physicians, clinicians, as well as other users, to discover Autism Spectrum Disorder (ASD) symptoms based on historical cases and controls to enhance autism screening efficiency and accuracy. The aim of this study is to improve the performance of detecting ASD traits by reducing data dimensionality and eliminating redundancy in the autism dataset. To achieve this, a new semi-supervised ML framework approach called Clustering-based Autistic Trait Classification (CATC) is proposed that uses a clustering technique and validation of the classifiers is done by classification techniques. The proposed method identifies potential autism cases based on their similarity traits as opposed to a scoring function used by many ASD screening tools. Empirical results on different datasets involving children, adolescents, and adults were verified and compared to other common machine learning classification techniques. The results showed that CATC offers classifiers with higher predictive accuracy, sensitivity, and specificity rates than those of other intelligent classification approaches such as Artificial Neural Network (ANN), Random Forest, and Random Trees, and Rule Induction. These classifiers are useful as they are exploited by diagnosticians and other stakeholders involved in ASD screening

New Research in Children with Neurodevelopmental Disorders

This book collects recent research in the field of care for neurodevelopmental disorders, emphasizing transdisciplinary work in clinical, educational and family contexts. It presents an opportunity to learn about the impact of participation on children and adolescents with neurodevelopmental disorders. Mainly, new therapeutic approaches are presented in children and adolescents with autism spectrum disorder, attention-deficit/hyperactivity disorder, or motor coordination disorders

Detecting Autistic Traits using Computational Intelligence & Machine Learning Techniques

Autistic Spectrum Disorder (ASD) is a developmental disorder that describes certain challenges associated with communication (verbal and non-verbal), social skills and repetitive behaviours. Self-administered ASD assessment tools, also known as screening tools, are typically conducted by a caregiver, medical staff and require responses to a large number of items. The validity and accuracy of assessments based on these tools relies upon classification methods which have antiquated technologies and this should be of concern for users in the healthcare community. A possible way to improve the classification accuracy and efficiency of the current screening tools is to adopt intelligent methods based on machine learning (ML) and computational intelligence. The latter can be utilised to identify a concise set of items by using new technologies such as mobile platforms, thus improving screening, or be able to steer those in seek of help toward a more accurate diagnosis. To automate the classification process and enhance the predictive accuracy of the test, the processing of data, based on the outcome of the computational intelligence, can be conducted using the former method. This thesis proposes a new ML architecture for ASD screening that consists of a rule-based classification method called Rules Machine Learning (RML) which generates high predictive rules that can be easily understood by different users. Moreover, a new feature selection method known as Variable Analysis (Va) is proposed; this significantly reduces the number of features needed for ASD screening methods while maintaining performance. The last proposal in this thesis is an easy and accessible mobile screening application called ASDTests, which enables vital autism features to be collected from three primary datasets: adults, children, and adolescents from which thorough descriptive and predictive analyses are performed. To measure the performance of the RML and Va methods, large numbers of experiments have been conducted using various feature selection and ML techniques on the considered datasets. The bases of the comparisons are: evaluation metrics including sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NVP), and harmonic mean. The results clearly demonstrated that the new ML method was able to choose fewer items from the three datasets than the other methods considered while maintaining acceptable levels of specificity, sensitivity, and predictive accuracy. The concise sets of items and classifiers generated are of high interest to the different individuals interested in ASD screening. These results can also assist in early detection of ASD traits, thus facilitating access to necessary support systems for the physical, social, and educational well-being of the patient and their family in addition to increasing the likelihood of improved outcomes for the patient

Advances in Autism Research

This book represents one of the most up-to-date collections of articles on clinical practice and research in the field of Autism Spectrum Disorders (ASD). The scholars who contributed to this book are experts in their field, carrying out cutting edge research in prestigious institutes worldwide (e.g., Harvard Medical School, University of California, MIND Institute, King’s College, Karolinska Institute, and many others). The book addressed many topics, including (1) The COVID-19 pandemic; (2) Epidemiology and prevalence; (3) Screening and early behavioral markers; (4) Diagnostic and phenotypic profile; (5) Treatment and intervention; (6) Etiopathogenesis (biomarkers, biology, and genetic, epigenetic, and risk factors); (7) Comorbidity; (8) Adulthood; and (9) Broader Autism Phenotype (BAP). This book testifies to the complexity of performing research in the field of ASD. The published contributions underline areas of progress and ongoing challenges in which more certain data is expected in the coming years. It would be desirable that experts, clinicians, researchers, and trainees could have the opportunity to read this updated text describing the challenging heterogeneity of Autism Spectrum Disorder

Pilot study for subgroup classification for autism spectrum disorder based on dysmorphology and physical measurements in Chinese children

Poster Sessions: 157 - Comorbid Medical Conditions: abstract 157.058 58BACKGROUND: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder affecting individuals along a continuum of severity in communication, social interaction and behaviour. The impact of ASD significantly varies amongst individuals, and the cause of ASD can originate broadly between genetic and environmental factors. Objectives: Previous ASD researches indicate that early identification combined with a targeted treatment plan involving behavioural interventions and multidisciplinary therapies can provide substantial improvement for ASD patients. Currently there is no cure for ASD, and the clinical variability and uncertainty of the disorder still remains. Hence, the search to unravel heterogeneity within ASD by subgroup classification may provide clinicians with a better understanding of ASD and to work towards a more definitive course of action. METHODS: In this study, a norm of physical measurements including height, weight, head circumference, ear length, outer and inner canthi, interpupillary distance, philtrum, hand and foot length was collected from 658 Typical Developing (TD) Chinese children aged 1 to 7 years (mean age of 4.19 years). The norm collected was compared against 80 ASD Chinese children aged 1 to 12 years (mean age of 4.36 years). We then further attempted to find subgroups within ASD based on identifying physical abnormalities; individuals were classified as (non) dysmorphic with the Autism Dysmorphology Measure (ADM) from physical examinations of 12 body regions. RESULTS: Our results show that there were significant differences between ASD and TD children for measurements in: head circumference (p=0.009), outer (p=0.021) and inner (p=0.021) canthus, philtrum length (p=0.003), right (p=0.023) and left (p=0.20) foot length. Within the 80 ASD patients, 37(46%) were classified as dysmorphic (p=0.00). CONCLUSIONS: This study attempts to identify subgroups within ASD based on physical measurements and dysmorphology examinations. The information from this study seeks to benefit ASD community by identifying possible subtypes of ASD in Chinese population; in seek for a more definitive diagnosis, referral and treatment plan.published_or_final_versio