37,320 research outputs found

    TSE-IDS: A Two-Stage Classifier Ensemble for Intelligent Anomaly-based Intrusion Detection System

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    Intrusion detection systems (IDS) play a pivotal role in computer security by discovering and repealing malicious activities in computer networks. Anomaly-based IDS, in particular, rely on classification models trained using historical data to discover such malicious activities. In this paper, an improved IDS based on hybrid feature selection and two-level classifier ensembles is proposed. An hybrid feature selection technique comprising three methods, i.e. particle swarm optimization, ant colony algorithm, and genetic algorithm, is utilized to reduce the feature size of the training datasets (NSL-KDD and UNSW-NB15 are considered in this paper). Features are selected based on the classification performance of a reduced error pruning tree (REPT) classifier. Then, a two-level classifier ensembles based on two meta learners, i.e., rotation forest and bagging, is proposed. On the NSL-KDD dataset, the proposed classifier shows 85.8% accuracy, 86.8% sensitivity, and 88.0% detection rate, which remarkably outperform other classification techniques recently proposed in the literature. Results regarding the UNSW-NB15 dataset also improve the ones achieved by several state of the art techniques. Finally, to verify the results, a two-step statistical significance test is conducted. This is not usually considered by IDS research thus far and, therefore, adds value to the experimental results achieved by the proposed classifier

    Prediction of non-genotoxic carcinogenicity based on genetic profiles of short term exposure assays

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    Non-genotoxic carcinogens are substances that induce tumorigenesis by non-mutagenic mechanisms and long term rodent bioassays are required to identify them. Recent studies have shown that transcription profiling can be applied to develop early identifiers for long term phenotypes. In this study, we used rat liver expression profiles from the NTP (National Toxicology Program, Research Triangle Park, USA) DrugMatrix Database to construct a gene classifier that can distinguish between non-genotoxic carcinogens and other chemicals. The model was based on short term exposure assays (3 days) and the training was limited to oxidative stressors, peroxisome proliferators and hormone modulators. Validation of the predictor was performed on independent toxicogenomic data (TG-GATEs, Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System, Osaka, Japan). To build our model we performed Random Forests together with a recursive elimination algorithm (VarSelRF). Gene set enrichment analysis was employed for functional interpretation. A total of 770 microarrays comprising 96 different compounds were analyzed and a predictor of 54 genes was built. Prediction accuracy was 0.85 in the training set, 0.87 in the test set and increased with increasing concentration in the validation set: 0.6 at low dose, 0.7 at medium doses and 0.81 at high doses. Pathway analysis revealed gene prominence of cellular respiration, energy production and lipoprotein metabolism. The biggest target of toxicogenomics is accurately predict the toxicity of unknown drugs. In this analysis, we presented a classifier that can predict non-genotoxic carcinogenicity by using short term exposure assays. In this approach, dose level is critical when evaluating chemicals at early time points.Fil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; ArgentinaFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; ArgentinaFil: Peral Garcia, Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria ; Argentin
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